Prevalence and antibiogram of aerobic bacterial isolates from pus samples in a tertiary care hospital of north Kerala, India
Assessment of pathogens diversity and evolving drug-resistant pattern is quite essential in the systematic management of infections. To regulate the pyogenic infection, 1350 (783 males and 567 females) pus samples collected from individuals attending a tertiary care hospital in Northern Kerala. Pat...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society of Land Measurements and Cadastre from Transylvania (SMTCT)
2024-03-01
|
| Series: | Notulae Scientia Biologicae |
| Subjects: | |
| Online Access: | https://www.notulaebiologicae.ro/index.php/nsb/article/view/11757 |
| _version_ | 1797231331792388096 |
|---|---|
| author | K. RAJALAKSHMY Saravana P. KUMARI Syed M. AHMED |
| author_facet | K. RAJALAKSHMY Saravana P. KUMARI Syed M. AHMED |
| author_sort | K. RAJALAKSHMY |
| collection | DOAJ |
| description |
Assessment of pathogens diversity and evolving drug-resistant pattern is quite essential in the systematic management of infections. To regulate the pyogenic infection, 1350 (783 males and 567 females) pus samples collected from individuals attending a tertiary care hospital in Northern Kerala. Pathogens isolated from the collected pus samples were identified based on the colony morphology, microscopic examination, and biochemical characteristics. About 84.44% of samples showed significant bacteria. The causative organisms were Staphylococcus aureus (28%), Escherichia coli (13%), Pseudomonas aeruginosa (12%), Klebsiella pneumonia (10%), coagulase negative Staphylococcus sp. (8%), Proteus mirabilis (6%), Streptococcus sp. (2%), Enterococcus faecalis (2%), Acenitobactor baumanii (1%), Citrobactor koseri (2%), Enterococcus faecium (2%), Enterococcus sp. (2%), Morganella morganii (1%), Proteus vulgaris (2%), and other less prominent bacteria (3%). The drug-resistant pattern of pathogens analyses against 29 contemporary antibiotics. Pathogenic Gram-negative bacteria (GNB) were sensitive to amikacin > imipenem > meropenem > tazobactum > gentamycin > chloramphenicol> ciprofloxacin > levofloxacin and resistant to clindamycin, erythromycin, linezolid, oxacillin, penicillin, and vancomycin. Gram-Positive Bacteria (GPB) were susceptible to linezolid > vancomycin > tetracycline > clindamycin > chloramphenicol > gentamycin > ciprofloxacin, and resistant to amikacin, imipenem, meropenem, and tazobactum. Overall, the study concludes that MDR S. aureus was the predominant cause of pyogenic infections, drug resistance pattern of the pathogens in the selected region and raises concerns for the need to analyze signaling mechanism that transforms a susceptible strain into a resistant to develop a suitable treatment strategy.
|
| first_indexed | 2024-04-24T15:42:41Z |
| format | Article |
| id | doaj.art-5165886cd92b47c59c78363ac390142b |
| institution | Directory Open Access Journal |
| issn | 2067-3264 |
| language | English |
| last_indexed | 2024-04-24T15:42:41Z |
| publishDate | 2024-03-01 |
| publisher | Society of Land Measurements and Cadastre from Transylvania (SMTCT) |
| record_format | Article |
| series | Notulae Scientia Biologicae |
| spelling | doaj.art-5165886cd92b47c59c78363ac390142b2024-04-01T18:32:20ZengSociety of Land Measurements and Cadastre from Transylvania (SMTCT)Notulae Scientia Biologicae2067-32642024-03-0116110.55779/nsb16111757Prevalence and antibiogram of aerobic bacterial isolates from pus samples in a tertiary care hospital of north Kerala, IndiaK. RAJALAKSHMY0Saravana P. KUMARI1Syed M. AHMED2RVS College of Arts and Science, Department of Microbiology, CoimbatoreRVS College of Arts and Science, Department of Microbiology, CoimbatoreMES Medical College Hospital, Department of Microbiology, Malappuram, Kerala Assessment of pathogens diversity and evolving drug-resistant pattern is quite essential in the systematic management of infections. To regulate the pyogenic infection, 1350 (783 males and 567 females) pus samples collected from individuals attending a tertiary care hospital in Northern Kerala. Pathogens isolated from the collected pus samples were identified based on the colony morphology, microscopic examination, and biochemical characteristics. About 84.44% of samples showed significant bacteria. The causative organisms were Staphylococcus aureus (28%), Escherichia coli (13%), Pseudomonas aeruginosa (12%), Klebsiella pneumonia (10%), coagulase negative Staphylococcus sp. (8%), Proteus mirabilis (6%), Streptococcus sp. (2%), Enterococcus faecalis (2%), Acenitobactor baumanii (1%), Citrobactor koseri (2%), Enterococcus faecium (2%), Enterococcus sp. (2%), Morganella morganii (1%), Proteus vulgaris (2%), and other less prominent bacteria (3%). The drug-resistant pattern of pathogens analyses against 29 contemporary antibiotics. Pathogenic Gram-negative bacteria (GNB) were sensitive to amikacin > imipenem > meropenem > tazobactum > gentamycin > chloramphenicol> ciprofloxacin > levofloxacin and resistant to clindamycin, erythromycin, linezolid, oxacillin, penicillin, and vancomycin. Gram-Positive Bacteria (GPB) were susceptible to linezolid > vancomycin > tetracycline > clindamycin > chloramphenicol > gentamycin > ciprofloxacin, and resistant to amikacin, imipenem, meropenem, and tazobactum. Overall, the study concludes that MDR S. aureus was the predominant cause of pyogenic infections, drug resistance pattern of the pathogens in the selected region and raises concerns for the need to analyze signaling mechanism that transforms a susceptible strain into a resistant to develop a suitable treatment strategy. https://www.notulaebiologicae.ro/index.php/nsb/article/view/11757Bacterial pathogendrug resistancepyogenic infectionsStaphylococcus aureussurgical site infection |
| spellingShingle | K. RAJALAKSHMY Saravana P. KUMARI Syed M. AHMED Prevalence and antibiogram of aerobic bacterial isolates from pus samples in a tertiary care hospital of north Kerala, India Notulae Scientia Biologicae Bacterial pathogen drug resistance pyogenic infections Staphylococcus aureus surgical site infection |
| title | Prevalence and antibiogram of aerobic bacterial isolates from pus samples in a tertiary care hospital of north Kerala, India |
| title_full | Prevalence and antibiogram of aerobic bacterial isolates from pus samples in a tertiary care hospital of north Kerala, India |
| title_fullStr | Prevalence and antibiogram of aerobic bacterial isolates from pus samples in a tertiary care hospital of north Kerala, India |
| title_full_unstemmed | Prevalence and antibiogram of aerobic bacterial isolates from pus samples in a tertiary care hospital of north Kerala, India |
| title_short | Prevalence and antibiogram of aerobic bacterial isolates from pus samples in a tertiary care hospital of north Kerala, India |
| title_sort | prevalence and antibiogram of aerobic bacterial isolates from pus samples in a tertiary care hospital of north kerala india |
| topic | Bacterial pathogen drug resistance pyogenic infections Staphylococcus aureus surgical site infection |
| url | https://www.notulaebiologicae.ro/index.php/nsb/article/view/11757 |
| work_keys_str_mv | AT krajalakshmy prevalenceandantibiogramofaerobicbacterialisolatesfrompussamplesinatertiarycarehospitalofnorthkeralaindia AT saravanapkumari prevalenceandantibiogramofaerobicbacterialisolatesfrompussamplesinatertiarycarehospitalofnorthkeralaindia AT syedmahmed prevalenceandantibiogramofaerobicbacterialisolatesfrompussamplesinatertiarycarehospitalofnorthkeralaindia |