Transmission characteristics and prevention measures of Naegleria fowleri： a review
ObjectiveTo review the Naegleria fowleri and primary amoebic meningoencephalitis caused by the naegleria fowleri， so as to strengthen the public awareness of the disease and its prevention.MethodsWe reviewed the literatures and reports， and summarized the following information： epidemic status， life...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Shanghai Preventive Medicine Association
2022-02-01
|
| Series: | Shanghai yufang yixue |
| Subjects: | |
| Online Access: | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2022.20636 |
| _version_ | 1797939229332865024 |
|---|---|
| author | ZHANG Na ZHOU Yibiao |
| author_facet | ZHANG Na ZHOU Yibiao |
| author_sort | ZHANG Na |
| collection | DOAJ |
| description | ObjectiveTo review the Naegleria fowleri and primary amoebic meningoencephalitis caused by the naegleria fowleri， so as to strengthen the public awareness of the disease and its prevention.MethodsWe reviewed the literatures and reports， and summarized the following information： epidemic status， life cycle and characteristics， environmental distribution and infection routes， pathogenesis and clinical manifestations， diagnosis and treatment， prevention and control measures.ResultsPrimary amoeba meningoencephalitis is a water-borne disease caused by the Naegleria fowleri， which enters human body through the nose and arrives at the central nervous system through olfactory nerve， leading to hemorrhagic and necrotic meningitis. Although the disease is rare， it has a fatality rate of 95%. Most of the patients reported were healthy children or young adults who had nasal contact with water contaminated with Naegleria fowleri a week before symptoms appeared. At present， its pathology can be divided into contact mechanism and non-contact mechanism. In contact mechanism， the Naegleria fowleri relies on the phagocytosis of food cup on its surface and the release of cytolytic molecules that directly destroy host cells. In non-contact mechanism， the Naegleria fowleri has toxic effects by secreting proteins. The clinical symptoms are episodic， with an average time of five days from illness to death. At beginning， the symptoms may include headache， vomiting， fever and other influenza-like symptoms， followed by central nervous system symptoms， such as stiff neck， drowsiness， anorexia， fear and so on. Intravenous or intrathecal injection of amphotericin B is considered to be the basic treatment of this disease， which can be combined with other adjunct therapies such as ventricular shunt and cooling to reduce encephaledema.ConclusionPrimary amoebic meningoencephalitis is a rare but highly fatal disease. We should strengthen the public awareness of the disease and its prevention， especially to avoid nasal contact with contaminated water. We should also strengthen scientific research， improve the level of diagnosis， and develop effective drugs to prevent the disease before it happens. |
| first_indexed | 2024-04-10T19:13:17Z |
| format | Article |
| id | doaj.art-5166903217954e169202c1e3e0311806 |
| institution | Directory Open Access Journal |
| issn | 1004-9231 |
| language | zho |
| last_indexed | 2024-04-10T19:13:17Z |
| publishDate | 2022-02-01 |
| publisher | Shanghai Preventive Medicine Association |
| record_format | Article |
| series | Shanghai yufang yixue |
| spelling | doaj.art-5166903217954e169202c1e3e03118062023-01-30T10:52:44ZzhoShanghai Preventive Medicine AssociationShanghai yufang yixue1004-92312022-02-0134218719110.19428/j.cnki.sjpm.2022.206361004-9231（2022）02-0187-05Transmission characteristics and prevention measures of Naegleria fowleri： a reviewZHANG NaZHOU YibiaoObjectiveTo review the Naegleria fowleri and primary amoebic meningoencephalitis caused by the naegleria fowleri， so as to strengthen the public awareness of the disease and its prevention.MethodsWe reviewed the literatures and reports， and summarized the following information： epidemic status， life cycle and characteristics， environmental distribution and infection routes， pathogenesis and clinical manifestations， diagnosis and treatment， prevention and control measures.ResultsPrimary amoeba meningoencephalitis is a water-borne disease caused by the Naegleria fowleri， which enters human body through the nose and arrives at the central nervous system through olfactory nerve， leading to hemorrhagic and necrotic meningitis. Although the disease is rare， it has a fatality rate of 95%. Most of the patients reported were healthy children or young adults who had nasal contact with water contaminated with Naegleria fowleri a week before symptoms appeared. At present， its pathology can be divided into contact mechanism and non-contact mechanism. In contact mechanism， the Naegleria fowleri relies on the phagocytosis of food cup on its surface and the release of cytolytic molecules that directly destroy host cells. In non-contact mechanism， the Naegleria fowleri has toxic effects by secreting proteins. The clinical symptoms are episodic， with an average time of five days from illness to death. At beginning， the symptoms may include headache， vomiting， fever and other influenza-like symptoms， followed by central nervous system symptoms， such as stiff neck， drowsiness， anorexia， fear and so on. Intravenous or intrathecal injection of amphotericin B is considered to be the basic treatment of this disease， which can be combined with other adjunct therapies such as ventricular shunt and cooling to reduce encephaledema.ConclusionPrimary amoebic meningoencephalitis is a rare but highly fatal disease. We should strengthen the public awareness of the disease and its prevention， especially to avoid nasal contact with contaminated water. We should also strengthen scientific research， improve the level of diagnosis， and develop effective drugs to prevent the disease before it happens.http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2022.20636naegleria fowleriprimary amoebic meningoencephalitis （pam）life cyclemechanismprevention |
| spellingShingle | ZHANG Na ZHOU Yibiao Transmission characteristics and prevention measures of Naegleria fowleri： a review Shanghai yufang yixue naegleria fowleri primary amoebic meningoencephalitis （pam） life cycle mechanism prevention |
| title | Transmission characteristics and prevention measures of Naegleria fowleri： a review |
| title_full | Transmission characteristics and prevention measures of Naegleria fowleri： a review |
| title_fullStr | Transmission characteristics and prevention measures of Naegleria fowleri： a review |
| title_full_unstemmed | Transmission characteristics and prevention measures of Naegleria fowleri： a review |
| title_short | Transmission characteristics and prevention measures of Naegleria fowleri： a review |
| title_sort | transmission characteristics and prevention measures of naegleria fowleri a review |
| topic | naegleria fowleri primary amoebic meningoencephalitis （pam） life cycle mechanism prevention |
| url | http://www.sjpm.org.cn/article/doi/10.19428/j.cnki.sjpm.2022.20636 |
| work_keys_str_mv | AT zhangna transmissioncharacteristicsandpreventionmeasuresofnaegleriafowleriareview AT zhouyibiao transmissioncharacteristicsandpreventionmeasuresofnaegleriafowleriareview |