Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight
The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/8/815 |
| _version_ | 1797715505245585408 |
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| author | Anne-Sophie Lamort Ioanna Giopanou Ioannis Psallidas Georgios T. Stathopoulos |
| author_facet | Anne-Sophie Lamort Ioanna Giopanou Ioannis Psallidas Georgios T. Stathopoulos |
| author_sort | Anne-Sophie Lamort |
| collection | DOAJ |
| description | The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples. |
| first_indexed | 2024-03-12T08:07:45Z |
| format | Article |
| id | doaj.art-516c1c5ef6674f9eb4ae3b18730339a9 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:07:45Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-516c1c5ef6674f9eb4ae3b18730339a92023-09-02T19:21:09ZengMDPI AGCells2073-44092019-08-018881510.3390/cells8080815cells8080815Osteopontin as a Link between Inflammation and Cancer: The Thorax in the SpotlightAnne-Sophie Lamort0Ioanna Giopanou1Ioannis Psallidas2Georgios T. Stathopoulos3Comprehensive Pneumology Center and Institute for Lung Biology and Disease, University Hospital, Ludwig-Maximilians University of Munich and Helmholtz Center Munich, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377 Munich, Bavaria, GermanyLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, Biomedical Sciences Research Center, 1 Asklepiou Str., University Campus, 26504 Rio, Achaia, GreeceLungs for Living Research Centre, UCL Respiratory, University College London, London WC1E6BT, UKComprehensive Pneumology Center and Institute for Lung Biology and Disease, University Hospital, Ludwig-Maximilians University of Munich and Helmholtz Center Munich, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, 81377 Munich, Bavaria, GermanyThe glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples.https://www.mdpi.com/2073-4409/8/8/815OPNsecreted phosphoprotein 1SPP1lung cancerinflammation |
| spellingShingle | Anne-Sophie Lamort Ioanna Giopanou Ioannis Psallidas Georgios T. Stathopoulos Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight Cells OPN secreted phosphoprotein 1 SPP1 lung cancer inflammation |
| title | Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight |
| title_full | Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight |
| title_fullStr | Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight |
| title_full_unstemmed | Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight |
| title_short | Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight |
| title_sort | osteopontin as a link between inflammation and cancer the thorax in the spotlight |
| topic | OPN secreted phosphoprotein 1 SPP1 lung cancer inflammation |
| url | https://www.mdpi.com/2073-4409/8/8/815 |
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