C-reactive Protein as a Diagnostic Marker of Bacterial Infection in Febrile Children
Introduction: Evaluation of febrile infants and children without focus possess a great clinical concern. Although several biochemical indices indicate diagnosis towards bacterial agents, combining low cost and easily performed haematological parameters could reasonably predict the presence of Bacter...
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JCDR Research and Publications Private Limited
2018-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/11259/34233_CE[Ra1]_F(SHU)_PF1(MJ_AP)_PFA(MJ_AP)_PB(MJ_AP)_PN(AP).pdf |
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| author | Bandya Sahoo Bhaskar Thakur Mukesh Kumar Jain Reshmi Mishra |
| author_facet | Bandya Sahoo Bhaskar Thakur Mukesh Kumar Jain Reshmi Mishra |
| author_sort | Bandya Sahoo |
| collection | DOAJ |
| description | Introduction: Evaluation of febrile infants and children without focus possess a great clinical concern. Although several biochemical indices indicate diagnosis towards bacterial agents, combining low cost and easily performed haematological parameters could reasonably predict the presence of Bacterial Infection (BI). Aim: To assess the value of C-reactive Protein (CRP) alone and in conjunction with total White Blood Cell (WBC) count and Absolute Neutrophil Count (ANC) in predicting bacterial infection in febrile children. Materials and Methods: A prospective study was conducted in the Department of Paediatrics of a tertiary care hospital among children aged 1 month to 14 years admitted with fever for >24 hours. Data were collected from 97 consecutive children in whom CRP and total blood count was advised at admission. These data were analysed to predict the presence of BI by investigating the diagnostic performance of CRP, WBC and ANC using standard statistical software Stata version 13.1. Results: BI was diagnosed in 41 children. Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), Diagnostic Accuracy (DA) of CRP for BI among the febrile infants were 83%, 75.0%, 71%, 86% and 78% respectively. The sensitivity and specificity were 61% and 98% when all the three parameters CRP, WBC and ANC were positive and were 95% and 45% when any of these parameters was positive. Conclusion: A definitive cut-off value of 1.2 mg/L for CRP is a reasonably good predictor of BI among febrile children. However, addition of other laboratory parameters (total leukocyte count and ANC may enhance clinician’s ability to discriminate bacterial from non BIs. |
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| issn | 2249-782X 0973-709X |
| language | English |
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| publishDate | 2018-03-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-516ce3476ed3464196e1e4bbd55fb2532022-12-22T03:00:26ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-03-01123SC05SC0810.7860/JCDR/2018/34233.11259C-reactive Protein as a Diagnostic Marker of Bacterial Infection in Febrile ChildrenBandya Sahoo0Bhaskar Thakur1Mukesh Kumar Jain2Reshmi Mishra3Associate Professor, Department of Paediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.Biostatistician, Department of Paediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.Assistant Professor, Department of Paediatrics, Kalinga institute of Medical sciences, Bhubaneswar, Odisha, India.Associate Professor, Department of Paediatrics, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.Introduction: Evaluation of febrile infants and children without focus possess a great clinical concern. Although several biochemical indices indicate diagnosis towards bacterial agents, combining low cost and easily performed haematological parameters could reasonably predict the presence of Bacterial Infection (BI). Aim: To assess the value of C-reactive Protein (CRP) alone and in conjunction with total White Blood Cell (WBC) count and Absolute Neutrophil Count (ANC) in predicting bacterial infection in febrile children. Materials and Methods: A prospective study was conducted in the Department of Paediatrics of a tertiary care hospital among children aged 1 month to 14 years admitted with fever for >24 hours. Data were collected from 97 consecutive children in whom CRP and total blood count was advised at admission. These data were analysed to predict the presence of BI by investigating the diagnostic performance of CRP, WBC and ANC using standard statistical software Stata version 13.1. Results: BI was diagnosed in 41 children. Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), Diagnostic Accuracy (DA) of CRP for BI among the febrile infants were 83%, 75.0%, 71%, 86% and 78% respectively. The sensitivity and specificity were 61% and 98% when all the three parameters CRP, WBC and ANC were positive and were 95% and 45% when any of these parameters was positive. Conclusion: A definitive cut-off value of 1.2 mg/L for CRP is a reasonably good predictor of BI among febrile children. However, addition of other laboratory parameters (total leukocyte count and ANC may enhance clinician’s ability to discriminate bacterial from non BIs.https://jcdr.net/articles/PDF/11259/34233_CE[Ra1]_F(SHU)_PF1(MJ_AP)_PFA(MJ_AP)_PB(MJ_AP)_PN(AP).pdfabsolute neutrophil countevaluationlow costpredictwhite blood cell count |
| spellingShingle | Bandya Sahoo Bhaskar Thakur Mukesh Kumar Jain Reshmi Mishra C-reactive Protein as a Diagnostic Marker of Bacterial Infection in Febrile Children Journal of Clinical and Diagnostic Research absolute neutrophil count evaluation low cost predict white blood cell count |
| title | C-reactive Protein as a Diagnostic Marker of Bacterial Infection in Febrile Children |
| title_full | C-reactive Protein as a Diagnostic Marker of Bacterial Infection in Febrile Children |
| title_fullStr | C-reactive Protein as a Diagnostic Marker of Bacterial Infection in Febrile Children |
| title_full_unstemmed | C-reactive Protein as a Diagnostic Marker of Bacterial Infection in Febrile Children |
| title_short | C-reactive Protein as a Diagnostic Marker of Bacterial Infection in Febrile Children |
| title_sort | c reactive protein as a diagnostic marker of bacterial infection in febrile children |
| topic | absolute neutrophil count evaluation low cost predict white blood cell count |
| url | https://jcdr.net/articles/PDF/11259/34233_CE[Ra1]_F(SHU)_PF1(MJ_AP)_PFA(MJ_AP)_PB(MJ_AP)_PN(AP).pdf |
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