Difunctional Hydrogel Optical Fiber Fluorescence Sensor for Continuous and Simultaneous Monitoring of Glucose and pH
It is significant for people with diabetes to know their body’s real-time glucose level, which can guide the diagnosis and treatment. Therefore, it is necessary to research continuous glucose monitoring (CGM) as it gives us real-time information about our health condition and its dynamic changes. He...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/2/287 |
| _version_ | 1797622059223744512 |
|---|---|
| author | Yangjie Li Site Luo Yongqiang Gui Xin Wang Ziyuan Tian Haihu Yu |
| author_facet | Yangjie Li Site Luo Yongqiang Gui Xin Wang Ziyuan Tian Haihu Yu |
| author_sort | Yangjie Li |
| collection | DOAJ |
| description | It is significant for people with diabetes to know their body’s real-time glucose level, which can guide the diagnosis and treatment. Therefore, it is necessary to research continuous glucose monitoring (CGM) as it gives us real-time information about our health condition and its dynamic changes. Here, we report a novel hydrogel optical fiber fluorescence sensor segmentally functionalized with fluorescein derivative and CdTe QDs/3-APBA, which can continuously monitor pH and glucose simultaneously. In the glucose detection section, the complexation of PBA and glucose will expand the local hydrogel and decrease the fluorescence of the quantum dots. The fluorescence can be transmitted to the detector by the hydrogel optical fiber in real time. As the complexation reaction and the swelling–deswelling of the hydrogel are all reversible, the dynamic change of glucose concentration can be monitored. For pH detection, the fluorescein attached to another segment of the hydrogel exhibits different protolytic forms when pH changes and the fluorescence changes correspondingly. The significance of pH detection is compensation for pH errors in glucose detection because the reaction between PBA and glucose is sensitive to pH. The emission peaks of the two detection units are 517 nm and 594 nm, respectively, so there is no signal interference between them. The sensor can continuously monitor glucose in 0–20 mM and pH in 5.4–7.8. The advantages of this sensor are multi-parameter simultaneous detection, transmission-detection integration, real-time dynamic detection, and good biocompatibility. |
| first_indexed | 2024-03-11T09:04:54Z |
| format | Article |
| id | doaj.art-516d9a293c244bc48965e670fe2f10e4 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-11T09:04:54Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-516d9a293c244bc48965e670fe2f10e42023-11-16T19:26:46ZengMDPI AGBiosensors2079-63742023-02-0113228710.3390/bios13020287Difunctional Hydrogel Optical Fiber Fluorescence Sensor for Continuous and Simultaneous Monitoring of Glucose and pHYangjie Li0Site Luo1Yongqiang Gui2Xin Wang3Ziyuan Tian4Haihu Yu5National Engineering Research Center of Fiber Optic Sensing Technology and Networks, Wuhan University of Technology, Wuhan 430070, ChinaNational Engineering Research Center of Fiber Optic Sensing Technology and Networks, Wuhan University of Technology, Wuhan 430070, ChinaNational Engineering Research Center of Fiber Optic Sensing Technology and Networks, Wuhan University of Technology, Wuhan 430070, ChinaNational Engineering Research Center of Fiber Optic Sensing Technology and Networks, Wuhan University of Technology, Wuhan 430070, ChinaNational Engineering Research Center of Fiber Optic Sensing Technology and Networks, Wuhan University of Technology, Wuhan 430070, ChinaNational Engineering Research Center of Fiber Optic Sensing Technology and Networks, Wuhan University of Technology, Wuhan 430070, ChinaIt is significant for people with diabetes to know their body’s real-time glucose level, which can guide the diagnosis and treatment. Therefore, it is necessary to research continuous glucose monitoring (CGM) as it gives us real-time information about our health condition and its dynamic changes. Here, we report a novel hydrogel optical fiber fluorescence sensor segmentally functionalized with fluorescein derivative and CdTe QDs/3-APBA, which can continuously monitor pH and glucose simultaneously. In the glucose detection section, the complexation of PBA and glucose will expand the local hydrogel and decrease the fluorescence of the quantum dots. The fluorescence can be transmitted to the detector by the hydrogel optical fiber in real time. As the complexation reaction and the swelling–deswelling of the hydrogel are all reversible, the dynamic change of glucose concentration can be monitored. For pH detection, the fluorescein attached to another segment of the hydrogel exhibits different protolytic forms when pH changes and the fluorescence changes correspondingly. The significance of pH detection is compensation for pH errors in glucose detection because the reaction between PBA and glucose is sensitive to pH. The emission peaks of the two detection units are 517 nm and 594 nm, respectively, so there is no signal interference between them. The sensor can continuously monitor glucose in 0–20 mM and pH in 5.4–7.8. The advantages of this sensor are multi-parameter simultaneous detection, transmission-detection integration, real-time dynamic detection, and good biocompatibility.https://www.mdpi.com/2079-6374/13/2/287hydrogel fiberglucosepHfluorescence sensorPBAfluorescein derivative |
| spellingShingle | Yangjie Li Site Luo Yongqiang Gui Xin Wang Ziyuan Tian Haihu Yu Difunctional Hydrogel Optical Fiber Fluorescence Sensor for Continuous and Simultaneous Monitoring of Glucose and pH Biosensors hydrogel fiber glucose pH fluorescence sensor PBA fluorescein derivative |
| title | Difunctional Hydrogel Optical Fiber Fluorescence Sensor for Continuous and Simultaneous Monitoring of Glucose and pH |
| title_full | Difunctional Hydrogel Optical Fiber Fluorescence Sensor for Continuous and Simultaneous Monitoring of Glucose and pH |
| title_fullStr | Difunctional Hydrogel Optical Fiber Fluorescence Sensor for Continuous and Simultaneous Monitoring of Glucose and pH |
| title_full_unstemmed | Difunctional Hydrogel Optical Fiber Fluorescence Sensor for Continuous and Simultaneous Monitoring of Glucose and pH |
| title_short | Difunctional Hydrogel Optical Fiber Fluorescence Sensor for Continuous and Simultaneous Monitoring of Glucose and pH |
| title_sort | difunctional hydrogel optical fiber fluorescence sensor for continuous and simultaneous monitoring of glucose and ph |
| topic | hydrogel fiber glucose pH fluorescence sensor PBA fluorescein derivative |
| url | https://www.mdpi.com/2079-6374/13/2/287 |
| work_keys_str_mv | AT yangjieli difunctionalhydrogelopticalfiberfluorescencesensorforcontinuousandsimultaneousmonitoringofglucoseandph AT siteluo difunctionalhydrogelopticalfiberfluorescencesensorforcontinuousandsimultaneousmonitoringofglucoseandph AT yongqianggui difunctionalhydrogelopticalfiberfluorescencesensorforcontinuousandsimultaneousmonitoringofglucoseandph AT xinwang difunctionalhydrogelopticalfiberfluorescencesensorforcontinuousandsimultaneousmonitoringofglucoseandph AT ziyuantian difunctionalhydrogelopticalfiberfluorescencesensorforcontinuousandsimultaneousmonitoringofglucoseandph AT haihuyu difunctionalhydrogelopticalfiberfluorescencesensorforcontinuousandsimultaneousmonitoringofglucoseandph |