Synthesis and Diels–Alder Reactivity of 4-Fluoro-4-Methyl-4<i>H</i>-Pyrazoles

Synthesis and Diels–Alder Reactivity of 4-Fluoro-4-Methyl-4<i>H</i>-Pyrazoles

4<i>H</i>-Pyrazoles are emerging scaffolds for “click” chemistry. Late-stage fluorination with Selectfluor<sup>®</sup> is found to provide a reliable route to 4-fluoro-4-methyl-4<i>H</i>-pyrazoles. 4-Fluoro-4-methyl-3,5-diphenyl-4<i>H</i>-pyrazole (MFP...

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Bibliographic Details
Main Authors:	Nile S. Abularrage, Brian J. Levandowski, Ronald T. Raines
Format:	Article
Language:	English
Published:	MDPI AG 2020-05-01
Series:	International Journal of Molecular Sciences
Subjects:	antiaromaticity click chemistry cycloaddition 4<i>H</i>-pyrazole hyperconjugation
Online Access:	https://www.mdpi.com/1422-0067/21/11/3964

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