Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells.

Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current study, we show that simvastatin decreased glucose-stim...

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Autors principals: Nagendra Yaluri, Shalem Modi, Maykel López Rodríguez, Alena Stančáková, Johanna Kuusisto, Tarja Kokkola, Markku Laakso
Format: Article
Idioma:English
Publicat: Public Library of Science (PLoS) 2015-01-01
Col·lecció:PLoS ONE
Accés en línia:https://doi.org/10.1371/journal.pone.0142902