Pathophysiological Mapping of Experimental Heart Failure: Left and Right Ventricular Remodeling in Transverse Aortic Constriction Is Temporally, Kinetically and Structurally Distinct

Pathophysiological Mapping of Experimental Heart Failure: Left and Right Ventricular Remodeling in Transverse Aortic Constriction Is Temporally, Kinetically and Structurally Distinct

A growing proportion of heart failure (HF) patients present with impairments in both ventricles. Experimental pressure-overload (i.e., transverse aortic constriction, TAC) induces left ventricle (LV) hypertrophy and failure, as well as right ventricle (RV) dysfunction. However, little is known about...

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Bibliographic Details
Main Authors: Mathew J. Platt, Jason S. Huber, Nadya Romanova, Keith R. Brunt, Jeremy A. Simpson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Physiology
Subjects:
diastolic dysfunction
pulmonary hypertension
left heart disease
concentric remodeling
mouse models
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00472/full

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