High-dose Intensity-modulated proton therapy versus Standard-dose Intensity-modulated RadIation therapy for esophageal squamous cell carcinoma (HI-SIRI): study protocol for a randomized controlled clinical trial

High-dose Intensity-modulated proton therapy versus Standard-dose Intensity-modulated RadIation therapy for esophageal squamous cell carcinoma (HI-SIRI): study protocol for a randomized controlled clinical trial

Abstract Background Chemoradiotherapy is the standard of care for esophageal cancer as a neoadjuvant treatment before surgery, or as a definitive treatment for unresectable disease. Intensity-modulated radiotherapy (IMRT) has been considered the standard radiation technique. However, patients suffer...

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Bibliographic Details
Main Authors: Chawalit Lertbutsayanukul, Sarin Kitpanit, Danita Kannarunimit, Chakkapong Chakkabat, Sornjarod Oonsiri, Kullathorn Thephamongkhol, Putipun Puataweepong, Kanyarat Katanyoo, Jirasak Sukhaboon, Chokaew Tovanabut, Sirikanya Chongsathientham, Pornravee Treeratsapanich, Jirarat Soonthornrak, Anussara Prayongrat
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Trials
Subjects:
Intensity-modulated proton therapy
Intensity-modulated radiotherapy
Esophageal cancer
Squamous cell carcinoma
Survival
Toxicity
Online Access:https://doi.org/10.1186/s13063-022-06822-8

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