Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure
Aims: We aimed to assess the associations of CAVI with exercise capacity in heart failure (HF) patients. In addition, we further examined their prognosis.Methods: We collected the clinical data of 223 patients who had been hospitalized for decompensated HF and had undergone both CAVI and cardiopulmo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.631807/full |
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| author | Koichiro Watanabe Akiomi Yoshihisa Akiomi Yoshihisa Yu Sato Yu Hotsuki Fumiya Anzai Yasuhiro Ichijo Yusuke Kimishima Tetsuro Yokokawa Tomofumi Misaka Tomofumi Misaka Takamasa Sato Takashi Kaneshiro Masayoshi Oikawa Atsushi Kobayashi Yasuchika Takeishi |
| author_facet | Koichiro Watanabe Akiomi Yoshihisa Akiomi Yoshihisa Yu Sato Yu Hotsuki Fumiya Anzai Yasuhiro Ichijo Yusuke Kimishima Tetsuro Yokokawa Tomofumi Misaka Tomofumi Misaka Takamasa Sato Takashi Kaneshiro Masayoshi Oikawa Atsushi Kobayashi Yasuchika Takeishi |
| author_sort | Koichiro Watanabe |
| collection | DOAJ |
| description | Aims: We aimed to assess the associations of CAVI with exercise capacity in heart failure (HF) patients. In addition, we further examined their prognosis.Methods: We collected the clinical data of 223 patients who had been hospitalized for decompensated HF and had undergone both CAVI and cardiopulmonary exercise testing.Results: For the prediction of an impaired peak oxygen uptake (VO2) of < 14 mL/kg/min, receiver-operating characteristic curve demonstrated that the cutoff value of CAVI was 8.9. In the multivariate logistic regression analysis for predicting impaired peak VO2, high CAVI was found to be an independent factor (odds ratio 2.343, P = 0.045). We divided these patients based on CAVI: the low-CAVI group (CAVI < 8.9, n = 145) and the high-CAVI group (CAVI ≥ 8.9, n = 78). Patient characteristics and post-discharge cardiac events were compared between the two groups. The high-CAVI group was older (69.0 vs. 58.0 years old, P < 0.001) and had lower body mass index (23.0 vs. 24.1 kg/m2, P = 0.013). During the post-discharge follow-up period of median 1,623 days, 58 cardiac events occurred. The Kaplan–Meier analysis demonstrated that the cardiac event rate was higher in the high-CAVI group than in the low-CAVI group (log–rank P = 0.004). The multivariate Cox proportional hazard analysis revealed that high CAVI was an independent predictor of cardiac events (hazard ratio 1.845, P = 0.035).Conclusion: High CAVI is independently associated with impaired exercise capacity and a high cardiac event rate in HF patients. |
| first_indexed | 2024-12-14T00:05:29Z |
| format | Article |
| id | doaj.art-5172ac90160c4543a1e5808b96d96c41 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-14T00:05:29Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-5172ac90160c4543a1e5808b96d96c412022-12-21T23:26:04ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-03-01810.3389/fcvm.2021.631807631807Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart FailureKoichiro Watanabe0Akiomi Yoshihisa1Akiomi Yoshihisa2Yu Sato3Yu Hotsuki4Fumiya Anzai5Yasuhiro Ichijo6Yusuke Kimishima7Tetsuro Yokokawa8Tomofumi Misaka9Tomofumi Misaka10Takamasa Sato11Takashi Kaneshiro12Masayoshi Oikawa13Atsushi Kobayashi14Yasuchika Takeishi15Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Advanced Cardiac Therapeutics, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Advanced Cardiac Therapeutics, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanDepartment of Cardiovascular Medicine, Fukushima Medical University, Fukushima, JapanAims: We aimed to assess the associations of CAVI with exercise capacity in heart failure (HF) patients. In addition, we further examined their prognosis.Methods: We collected the clinical data of 223 patients who had been hospitalized for decompensated HF and had undergone both CAVI and cardiopulmonary exercise testing.Results: For the prediction of an impaired peak oxygen uptake (VO2) of < 14 mL/kg/min, receiver-operating characteristic curve demonstrated that the cutoff value of CAVI was 8.9. In the multivariate logistic regression analysis for predicting impaired peak VO2, high CAVI was found to be an independent factor (odds ratio 2.343, P = 0.045). We divided these patients based on CAVI: the low-CAVI group (CAVI < 8.9, n = 145) and the high-CAVI group (CAVI ≥ 8.9, n = 78). Patient characteristics and post-discharge cardiac events were compared between the two groups. The high-CAVI group was older (69.0 vs. 58.0 years old, P < 0.001) and had lower body mass index (23.0 vs. 24.1 kg/m2, P = 0.013). During the post-discharge follow-up period of median 1,623 days, 58 cardiac events occurred. The Kaplan–Meier analysis demonstrated that the cardiac event rate was higher in the high-CAVI group than in the low-CAVI group (log–rank P = 0.004). The multivariate Cox proportional hazard analysis revealed that high CAVI was an independent predictor of cardiac events (hazard ratio 1.845, P = 0.035).Conclusion: High CAVI is independently associated with impaired exercise capacity and a high cardiac event rate in HF patients.https://www.frontiersin.org/articles/10.3389/fcvm.2021.631807/fullcardio-ankle vascular indexarterial stiffnesscardiopulmonary exercise testingheart failureprognosis |
| spellingShingle | Koichiro Watanabe Akiomi Yoshihisa Akiomi Yoshihisa Yu Sato Yu Hotsuki Fumiya Anzai Yasuhiro Ichijo Yusuke Kimishima Tetsuro Yokokawa Tomofumi Misaka Tomofumi Misaka Takamasa Sato Takashi Kaneshiro Masayoshi Oikawa Atsushi Kobayashi Yasuchika Takeishi Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure Frontiers in Cardiovascular Medicine cardio-ankle vascular index arterial stiffness cardiopulmonary exercise testing heart failure prognosis |
| title | Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure |
| title_full | Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure |
| title_fullStr | Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure |
| title_full_unstemmed | Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure |
| title_short | Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure |
| title_sort | cardio ankle vascular index reflects impaired exercise capacity and predicts adverse prognosis in patients with heart failure |
| topic | cardio-ankle vascular index arterial stiffness cardiopulmonary exercise testing heart failure prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.631807/full |
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