Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals
Abstract Naturally occurring tumor in animals receiving high minerals from deep oceans (DOM: hardness 600 mg/L) from 6 months of age until natural death was firstly assessed in 200 Sprague Dawley rats, randomized into four groups: Control (C), DOM (D), Fructose (F), and Fructose + DOM (FD). Fructose...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-06-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.3028 |
| _version_ | 1818260471032053760 |
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| author | Suchada Saovieng Jinfu Wu Wei‐Horng Jean Chih‐Yang Huang Matthew F. Higgins Ahmad Alkhatib Mallikarjuna Korivi Chiao‐Nan Chen Chia‐Hua Kuo |
| author_facet | Suchada Saovieng Jinfu Wu Wei‐Horng Jean Chih‐Yang Huang Matthew F. Higgins Ahmad Alkhatib Mallikarjuna Korivi Chiao‐Nan Chen Chia‐Hua Kuo |
| author_sort | Suchada Saovieng |
| collection | DOAJ |
| description | Abstract Naturally occurring tumor in animals receiving high minerals from deep oceans (DOM: hardness 600 mg/L) from 6 months of age until natural death was firstly assessed in 200 Sprague Dawley rats, randomized into four groups: Control (C), DOM (D), Fructose (F), and Fructose + DOM (FD). Fructose drink contained 11% fructose. Tumor incidence (necropsy at death) in the D group was ~40% lower than that in the C group (P < .05), together with lower body mass gain and greater locomotive activity during their initial 18 months (P < .05) but not during later life. X‐ray image analysis on abnormal solid tissue among survivors at 18 and 24 months of age confirms a similar trend, exhibiting ~50% and ~65% lower tumor incidence than the C and F groups, respectively. Reduced‐to‐oxidized glutathione ratio (GSH/GSSG) declined with age for the first three quarters of life on all groups (P < .05), followed by a resurgence during end‐life among survivors at 24 months. This resurgence is markedly associated with lower tumor expansion but unrelated with DOM supplementation. Our results demonstrate valuable application of minerals and trace elements from deep oceans, as a vastly available natural source, on tumor suppression during normal aging. |
| first_indexed | 2024-12-12T18:31:51Z |
| format | Article |
| id | doaj.art-51732dfc274f49bc8387546b3cb18ada |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-12T18:31:51Z |
| publishDate | 2020-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-51732dfc274f49bc8387546b3cb18ada2022-12-22T00:15:53ZengWileyCancer Medicine2045-76342020-06-019113964397310.1002/cam4.3028Lower tumorigenesis without life extension in rats receiving lifelong deep ocean mineralsSuchada Saovieng0Jinfu Wu1Wei‐Horng Jean2Chih‐Yang Huang3Matthew F. Higgins4Ahmad Alkhatib5Mallikarjuna Korivi6Chiao‐Nan Chen7Chia‐Hua Kuo8Laboratory of Exercise Biochemistry University of Taipei Taipei Taiwan ROCLaboratory of Exercise Biochemistry University of Taipei Taipei Taiwan ROCDepartment of Anesthesiology Far East Memorial Hospital New Taipei Taiwan ROCCollege of Medicine Hualien Tzu Chi Hospital Tzu Chi Medical Foundation Tzu Chi University Hualien Taiwan ROCHuman Sciences Research Centre University of Derby Derby UKSchool of Health and Life Sciences Teesside University Middlesbrough UKCollege of Physical Education Zhejiang Normal University Jinhua Zhejiang P.R. ChinaDepartment of Physical Therapy and Assistive Technology National Yang Ming University Taipei Taiwan ROCLaboratory of Exercise Biochemistry University of Taipei Taipei Taiwan ROCAbstract Naturally occurring tumor in animals receiving high minerals from deep oceans (DOM: hardness 600 mg/L) from 6 months of age until natural death was firstly assessed in 200 Sprague Dawley rats, randomized into four groups: Control (C), DOM (D), Fructose (F), and Fructose + DOM (FD). Fructose drink contained 11% fructose. Tumor incidence (necropsy at death) in the D group was ~40% lower than that in the C group (P < .05), together with lower body mass gain and greater locomotive activity during their initial 18 months (P < .05) but not during later life. X‐ray image analysis on abnormal solid tissue among survivors at 18 and 24 months of age confirms a similar trend, exhibiting ~50% and ~65% lower tumor incidence than the C and F groups, respectively. Reduced‐to‐oxidized glutathione ratio (GSH/GSSG) declined with age for the first three quarters of life on all groups (P < .05), followed by a resurgence during end‐life among survivors at 24 months. This resurgence is markedly associated with lower tumor expansion but unrelated with DOM supplementation. Our results demonstrate valuable application of minerals and trace elements from deep oceans, as a vastly available natural source, on tumor suppression during normal aging.https://doi.org/10.1002/cam4.3028cancerfructoseglutathionelifespantumor |
| spellingShingle | Suchada Saovieng Jinfu Wu Wei‐Horng Jean Chih‐Yang Huang Matthew F. Higgins Ahmad Alkhatib Mallikarjuna Korivi Chiao‐Nan Chen Chia‐Hua Kuo Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals Cancer Medicine cancer fructose glutathione lifespan tumor |
| title | Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals |
| title_full | Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals |
| title_fullStr | Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals |
| title_full_unstemmed | Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals |
| title_short | Lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals |
| title_sort | lower tumorigenesis without life extension in rats receiving lifelong deep ocean minerals |
| topic | cancer fructose glutathione lifespan tumor |
| url | https://doi.org/10.1002/cam4.3028 |
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