Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut
AM0627 is a bis-O-glycan mucinase that might work in the final steps of mucus degradation, thereby providing a carbon and nitrogen source for Akkermansia muciniphila. Here, the authors provide molecular insights into AM0627 function from X-ray crystallography and computer simulations.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32021-9 |
| _version_ | 1811223050530586624 |
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| author | Víctor Taleb Qinghua Liao Yoshiki Narimatsu Ana García-García Ismael Compañón Rafael Junqueira Borges Andrés Manuel González-Ramírez Francisco Corzana Henrik Clausen Carme Rovira Ramon Hurtado-Guerrero |
| author_facet | Víctor Taleb Qinghua Liao Yoshiki Narimatsu Ana García-García Ismael Compañón Rafael Junqueira Borges Andrés Manuel González-Ramírez Francisco Corzana Henrik Clausen Carme Rovira Ramon Hurtado-Guerrero |
| author_sort | Víctor Taleb |
| collection | DOAJ |
| description | AM0627 is a bis-O-glycan mucinase that might work in the final steps of mucus degradation, thereby providing a carbon and nitrogen source for Akkermansia muciniphila. Here, the authors provide molecular insights into AM0627 function from X-ray crystallography and computer simulations. |
| first_indexed | 2024-04-12T08:26:23Z |
| format | Article |
| id | doaj.art-51738a196d424c47bf488285e9c058f0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T08:26:23Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-51738a196d424c47bf488285e9c058f02022-12-22T03:40:23ZengNature PortfolioNature Communications2041-17232022-07-0113111510.1038/s41467-022-32021-9Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gutVíctor Taleb0Qinghua Liao1Yoshiki Narimatsu2Ana García-García3Ismael Compañón4Rafael Junqueira Borges5Andrés Manuel González-Ramírez6Francisco Corzana7Henrik Clausen8Carme Rovira9Ramon Hurtado-Guerrero10Institute of Biocomputation and Physics of Complex Systems, University of ZaragozaDepartament de Química Inorgánica i Orgánica (Secció de Química Orgánica) and Institut de Química Teorica i Computacional (IQTCUB), Universitat de BarcelonaCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of CopenhagenInstitute of Biocomputation and Physics of Complex Systems, University of ZaragozaDepartamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis QuímicaDepartamento de Biofísica e Farmacologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP)Institute of Biocomputation and Physics of Complex Systems, University of ZaragozaDepartamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis QuímicaCopenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of CopenhagenDepartament de Química Inorgánica i Orgánica (Secció de Química Orgánica) and Institut de Química Teorica i Computacional (IQTCUB), Universitat de BarcelonaInstitute of Biocomputation and Physics of Complex Systems, University of ZaragozaAM0627 is a bis-O-glycan mucinase that might work in the final steps of mucus degradation, thereby providing a carbon and nitrogen source for Akkermansia muciniphila. Here, the authors provide molecular insights into AM0627 function from X-ray crystallography and computer simulations.https://doi.org/10.1038/s41467-022-32021-9 |
| spellingShingle | Víctor Taleb Qinghua Liao Yoshiki Narimatsu Ana García-García Ismael Compañón Rafael Junqueira Borges Andrés Manuel González-Ramírez Francisco Corzana Henrik Clausen Carme Rovira Ramon Hurtado-Guerrero Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut Nature Communications |
| title | Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut |
| title_full | Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut |
| title_fullStr | Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut |
| title_full_unstemmed | Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut |
| title_short | Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut |
| title_sort | structural and mechanistic insights into the cleavage of clustered o glycan patches containing glycoproteins by mucinases of the human gut |
| url | https://doi.org/10.1038/s41467-022-32021-9 |
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