Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation
Cerebellar ataxias (CAs) are neurological diseases characterized by loss of muscle coordination that is a result of damage and inflammation to the cerebellum. Despite considerable efforts in basic and clinical research, most CAs are currently incurable. In this study, we evaluated the therapeutic po...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/11/3654 |
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| author | Youngpyo Nam Dongyeong Yoon Jungwan Hong Min Sung Kim Tae Yong Lee Kyung Suk Kim Ho-Won Lee Kyoungho Suk Sang Ryong Kim |
| author_facet | Youngpyo Nam Dongyeong Yoon Jungwan Hong Min Sung Kim Tae Yong Lee Kyung Suk Kim Ho-Won Lee Kyoungho Suk Sang Ryong Kim |
| author_sort | Youngpyo Nam |
| collection | DOAJ |
| description | Cerebellar ataxias (CAs) are neurological diseases characterized by loss of muscle coordination that is a result of damage and inflammation to the cerebellum. Despite considerable efforts in basic and clinical research, most CAs are currently incurable. In this study, we evaluated the therapeutic potential of human mesenchymal stem cells (hMSCs) against CAs associated with neuroinflammation. We observed that hMSC treatment significantly inhibited the symptoms of ataxia in lipopolysaccharide (LPS)-induced inflammatory CA (ICA) mice, which were recently reported as a potential animal model of ICA, through the anti-inflammatory effect of hMSC-derived TNFα-stimulated gene-6 (TSG-6), the protection of Purkinje cells by inhibition of apoptosis, and the modulatory effect for microglial M2 polarization. Thus, our results suggest that hMSC treatment may be an effective therapeutic approach for preventing or improving ataxia symptoms. |
| first_indexed | 2024-03-10T14:51:43Z |
| format | Article |
| id | doaj.art-51755b37d2bd4244b938ccfa5ff20625 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T14:51:43Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-51755b37d2bd4244b938ccfa5ff206252023-11-20T20:52:54ZengMDPI AGJournal of Clinical Medicine2077-03832020-11-01911365410.3390/jcm9113654Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with NeuroinflammationYoungpyo Nam0Dongyeong Yoon1Jungwan Hong2Min Sung Kim3Tae Yong Lee4Kyung Suk Kim5Ho-Won Lee6Kyoungho Suk7Sang Ryong Kim8Brain Science and Engineering Institute, Kyungpook National University, Daegu 41566, KoreaBK21 Plus KNU Creative BioResearch Group, School of Life Sciences, Kyungpook National University, Daegu 41566, KoreaBrain Science and Engineering Institute, Kyungpook National University, Daegu 41566, KoreaBioengineering Institute, Corestem Inc., Seoul 13486, KoreaBioengineering Institute, Corestem Inc., Seoul 13486, KoreaBioengineering Institute, Corestem Inc., Seoul 13486, KoreaBrain Science and Engineering Institute, Kyungpook National University, Daegu 41566, KoreaBrain Science and Engineering Institute, Kyungpook National University, Daegu 41566, KoreaBrain Science and Engineering Institute, Kyungpook National University, Daegu 41566, KoreaCerebellar ataxias (CAs) are neurological diseases characterized by loss of muscle coordination that is a result of damage and inflammation to the cerebellum. Despite considerable efforts in basic and clinical research, most CAs are currently incurable. In this study, we evaluated the therapeutic potential of human mesenchymal stem cells (hMSCs) against CAs associated with neuroinflammation. We observed that hMSC treatment significantly inhibited the symptoms of ataxia in lipopolysaccharide (LPS)-induced inflammatory CA (ICA) mice, which were recently reported as a potential animal model of ICA, through the anti-inflammatory effect of hMSC-derived TNFα-stimulated gene-6 (TSG-6), the protection of Purkinje cells by inhibition of apoptosis, and the modulatory effect for microglial M2 polarization. Thus, our results suggest that hMSC treatment may be an effective therapeutic approach for preventing or improving ataxia symptoms.https://www.mdpi.com/2077-0383/9/11/3654cerebellar ataxianeuroinflammationmicrogliamesenchymal stem celllipopolysaccharide |
| spellingShingle | Youngpyo Nam Dongyeong Yoon Jungwan Hong Min Sung Kim Tae Yong Lee Kyung Suk Kim Ho-Won Lee Kyoungho Suk Sang Ryong Kim Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation Journal of Clinical Medicine cerebellar ataxia neuroinflammation microglia mesenchymal stem cell lipopolysaccharide |
| title | Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation |
| title_full | Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation |
| title_fullStr | Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation |
| title_full_unstemmed | Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation |
| title_short | Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation |
| title_sort | therapeutic effects of human mesenchymal stem cells in a mouse model of cerebellar ataxia with neuroinflammation |
| topic | cerebellar ataxia neuroinflammation microglia mesenchymal stem cell lipopolysaccharide |
| url | https://www.mdpi.com/2077-0383/9/11/3654 |
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