The role of vaspin as a predictor of coronary angiography result in SCAD (stable coronary artery disease) patients
Abstract Background The role of vaspin in the pathogenesis of stable coronary artery disease (SCAD) have been repeatedly addressed in clinical studies. However, from the point of view of clinical practice, the results of earlier studies are still inconclusive. Methods The data of 106 SCAD patients w...
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12872-017-0550-1 |
| _version_ | 1818981397076901888 |
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| author | Matej Stančík Ivana Ságová Ema Kantorová Marián Mokáň |
| author_facet | Matej Stančík Ivana Ságová Ema Kantorová Marián Mokáň |
| author_sort | Matej Stančík |
| collection | DOAJ |
| description | Abstract Background The role of vaspin in the pathogenesis of stable coronary artery disease (SCAD) have been repeatedly addressed in clinical studies. However, from the point of view of clinical practice, the results of earlier studies are still inconclusive. Methods The data of 106 SCAD patients who received coronary angiography and 85 coronary artery disease-free controls were collected and analysed. The patients were divided into subgroups according to their pre-test probability (PTP) and according to the result of coronary angiography. Fasting vaspin concentrations were compared between subgroups of SCAD patients and between target group and controls. The effect of age and smoking on the result of coronary angiography was compared to the effect of vaspin using the binomial regression. Results We did not find significant difference in vaspin level between target group and controls. Unless the pre-test probability was taken into account, we did not find vaspin difference in the target group, when dividing patients on the basis of presence/absence of significant coronary stenosis. In the subgroup of SCAD patients with PTP between 15% – 65%, those with significant coronary stenoses had higher mean vaspin concentration (0,579 ± 0,898 ng/ml) than patients without significant stenoses. (0,379 ± 0,732 ng/ml) (t = −2595; p = 0,012; d = 0,658; 1-β = 0,850). Age, smoking status and vaspin significantly contributed to the HSCS prediction in binomial regression model in patients with low PTP (OR: 1.1, 4.9, 8.7, respectively). Conclusion According to our results, vaspin cannot be used as an independent marker for the presence of CAD in general population. However, our results indicate that measuring vaspin in SCAD patients might be clinically useful in patients with PTP below 66%. |
| first_indexed | 2024-12-20T17:30:40Z |
| format | Article |
| id | doaj.art-517a363d42d5499698a03b69ec0b9dec |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-20T17:30:40Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-517a363d42d5499698a03b69ec0b9dec2022-12-21T19:31:24ZengBMCBMC Cardiovascular Disorders1471-22612017-05-011711910.1186/s12872-017-0550-1The role of vaspin as a predictor of coronary angiography result in SCAD (stable coronary artery disease) patientsMatej Stančík0Ivana Ságová1Ema Kantorová2Marián Mokáň3Clinic of Internal Medicine I., Jessenius Faculty of Medicine in Martin, Comenius University in BratislavaClinic of Internal Medicine I., Jessenius Faculty of Medicine in Martin, Comenius University in BratislavaClinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in BratislavaClinic of Internal Medicine I., Jessenius Faculty of Medicine in Martin, Comenius University in BratislavaAbstract Background The role of vaspin in the pathogenesis of stable coronary artery disease (SCAD) have been repeatedly addressed in clinical studies. However, from the point of view of clinical practice, the results of earlier studies are still inconclusive. Methods The data of 106 SCAD patients who received coronary angiography and 85 coronary artery disease-free controls were collected and analysed. The patients were divided into subgroups according to their pre-test probability (PTP) and according to the result of coronary angiography. Fasting vaspin concentrations were compared between subgroups of SCAD patients and between target group and controls. The effect of age and smoking on the result of coronary angiography was compared to the effect of vaspin using the binomial regression. Results We did not find significant difference in vaspin level between target group and controls. Unless the pre-test probability was taken into account, we did not find vaspin difference in the target group, when dividing patients on the basis of presence/absence of significant coronary stenosis. In the subgroup of SCAD patients with PTP between 15% – 65%, those with significant coronary stenoses had higher mean vaspin concentration (0,579 ± 0,898 ng/ml) than patients without significant stenoses. (0,379 ± 0,732 ng/ml) (t = −2595; p = 0,012; d = 0,658; 1-β = 0,850). Age, smoking status and vaspin significantly contributed to the HSCS prediction in binomial regression model in patients with low PTP (OR: 1.1, 4.9, 8.7, respectively). Conclusion According to our results, vaspin cannot be used as an independent marker for the presence of CAD in general population. However, our results indicate that measuring vaspin in SCAD patients might be clinically useful in patients with PTP below 66%.http://link.springer.com/article/10.1186/s12872-017-0550-1AdipocytokineVaspinStable coronary artery diseaseCoronary angiographyPre-test probability |
| spellingShingle | Matej Stančík Ivana Ságová Ema Kantorová Marián Mokáň The role of vaspin as a predictor of coronary angiography result in SCAD (stable coronary artery disease) patients BMC Cardiovascular Disorders Adipocytokine Vaspin Stable coronary artery disease Coronary angiography Pre-test probability |
| title | The role of vaspin as a predictor of coronary angiography result in SCAD (stable coronary artery disease) patients |
| title_full | The role of vaspin as a predictor of coronary angiography result in SCAD (stable coronary artery disease) patients |
| title_fullStr | The role of vaspin as a predictor of coronary angiography result in SCAD (stable coronary artery disease) patients |
| title_full_unstemmed | The role of vaspin as a predictor of coronary angiography result in SCAD (stable coronary artery disease) patients |
| title_short | The role of vaspin as a predictor of coronary angiography result in SCAD (stable coronary artery disease) patients |
| title_sort | role of vaspin as a predictor of coronary angiography result in scad stable coronary artery disease patients |
| topic | Adipocytokine Vaspin Stable coronary artery disease Coronary angiography Pre-test probability |
| url | http://link.springer.com/article/10.1186/s12872-017-0550-1 |
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