Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action
Catecholamines modulate the impact of motivational cues on action. Such motivational biases have been proposed to reflect cue-based, ‘Pavlovian’ effects. Here, we assess whether motivational biases may also arise from asymmetrical instrumental learning of active and passive responses following rewar...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2017-05-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/22169 |
| _version_ | 1811199375630663680 |
|---|---|
| author | Jennifer C Swart Monja I Froböse Jennifer L Cook Dirk EM Geurts Michael J Frank Roshan Cools Hanneke EM den Ouden |
| author_facet | Jennifer C Swart Monja I Froböse Jennifer L Cook Dirk EM Geurts Michael J Frank Roshan Cools Hanneke EM den Ouden |
| author_sort | Jennifer C Swart |
| collection | DOAJ |
| description | Catecholamines modulate the impact of motivational cues on action. Such motivational biases have been proposed to reflect cue-based, ‘Pavlovian’ effects. Here, we assess whether motivational biases may also arise from asymmetrical instrumental learning of active and passive responses following reward and punishment outcomes. We present a novel paradigm, allowing us to disentangle the impact of reward and punishment on instrumental learning from Pavlovian response biasing. Computational analyses showed that motivational biases reflect both Pavlovian and instrumental effects: reward and punishment cues promoted generalized (in)action in a Pavlovian manner, whereas outcomes enhanced instrumental (un)learning of chosen actions. These cue- and outcome-based biases were altered independently by the catecholamine enhancer melthylphenidate. Methylphenidate’s effect varied across individuals with a putative proxy of baseline dopamine synthesis capacity, working memory span. Our study uncovers two distinct mechanisms by which motivation impacts behaviour, and helps refine current models of catecholaminergic modulation of motivated action. |
| first_indexed | 2024-04-12T01:47:16Z |
| format | Article |
| id | doaj.art-517cffd6038f47d6965246e9e5fa188c |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:47:16Z |
| publishDate | 2017-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-517cffd6038f47d6965246e9e5fa188c2022-12-22T03:53:02ZengeLife Sciences Publications LtdeLife2050-084X2017-05-01610.7554/eLife.22169Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)actionJennifer C Swart0https://orcid.org/0000-0003-0989-332XMonja I Froböse1Jennifer L Cook2Dirk EM Geurts3https://orcid.org/0000-0002-2505-1301Michael J Frank4https://orcid.org/0000-0001-8451-0523Roshan Cools5Hanneke EM den Ouden6Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The NetherlandsDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The NetherlandsDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands; School of Psychology, University of Birmingham, Birmingham, United KingdomDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands; Department of Psychiatry, Radboud University Medical Center, Nijmegen, The NetherlandsDepartment of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, United States; Brown Institute for Brain Sciences, Brown University, Providence, United StatesDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands; Department of Psychiatry, Radboud University Medical Center, Nijmegen, The NetherlandsDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The NetherlandsCatecholamines modulate the impact of motivational cues on action. Such motivational biases have been proposed to reflect cue-based, ‘Pavlovian’ effects. Here, we assess whether motivational biases may also arise from asymmetrical instrumental learning of active and passive responses following reward and punishment outcomes. We present a novel paradigm, allowing us to disentangle the impact of reward and punishment on instrumental learning from Pavlovian response biasing. Computational analyses showed that motivational biases reflect both Pavlovian and instrumental effects: reward and punishment cues promoted generalized (in)action in a Pavlovian manner, whereas outcomes enhanced instrumental (un)learning of chosen actions. These cue- and outcome-based biases were altered independently by the catecholamine enhancer melthylphenidate. Methylphenidate’s effect varied across individuals with a putative proxy of baseline dopamine synthesis capacity, working memory span. Our study uncovers two distinct mechanisms by which motivation impacts behaviour, and helps refine current models of catecholaminergic modulation of motivated action.https://elifesciences.org/articles/22169dopaminelearningmotivational biases |
| spellingShingle | Jennifer C Swart Monja I Froböse Jennifer L Cook Dirk EM Geurts Michael J Frank Roshan Cools Hanneke EM den Ouden Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action eLife dopamine learning motivational biases |
| title | Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action |
| title_full | Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action |
| title_fullStr | Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action |
| title_full_unstemmed | Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action |
| title_short | Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in)action |
| title_sort | catecholaminergic challenge uncovers distinct pavlovian and instrumental mechanisms of motivated in action |
| topic | dopamine learning motivational biases |
| url | https://elifesciences.org/articles/22169 |
| work_keys_str_mv | AT jennifercswart catecholaminergicchallengeuncoversdistinctpavlovianandinstrumentalmechanismsofmotivatedinaction AT monjaifrobose catecholaminergicchallengeuncoversdistinctpavlovianandinstrumentalmechanismsofmotivatedinaction AT jenniferlcook catecholaminergicchallengeuncoversdistinctpavlovianandinstrumentalmechanismsofmotivatedinaction AT dirkemgeurts catecholaminergicchallengeuncoversdistinctpavlovianandinstrumentalmechanismsofmotivatedinaction AT michaeljfrank catecholaminergicchallengeuncoversdistinctpavlovianandinstrumentalmechanismsofmotivatedinaction AT roshancools catecholaminergicchallengeuncoversdistinctpavlovianandinstrumentalmechanismsofmotivatedinaction AT hannekeemdenouden catecholaminergicchallengeuncoversdistinctpavlovianandinstrumentalmechanismsofmotivatedinaction |