Endocrine side effects of immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) have increasingly been the mainstay of treatment for numerous malignancies. However, due to their association with autoimmunity, ICIs have resulted in a variety of side effects that involve multiple organs including the endocrine system. In this review article, we...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1157805/full |
| _version_ | 1797829267856293888 |
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| author | Zulma Cardona Jeffrey A. Sosman Sunandana Chandra Wenyu Huang |
| author_facet | Zulma Cardona Jeffrey A. Sosman Sunandana Chandra Wenyu Huang |
| author_sort | Zulma Cardona |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs) have increasingly been the mainstay of treatment for numerous malignancies. However, due to their association with autoimmunity, ICIs have resulted in a variety of side effects that involve multiple organs including the endocrine system. In this review article, we describe our current understanding of the autoimmune endocrinopathies as a result of the use of ICIs. We will review the epidemiology, pathophysiology, clinical presentation, diagnosis, and management of the most commonly encountered endocrinopathies, including thyroiditis, hypophysitis, Type 1 diabetes, adrenalitis, and central diabetes insipidus. |
| first_indexed | 2024-04-09T13:17:46Z |
| format | Article |
| id | doaj.art-517e94373a8e404db7b5de93e9ff9be2 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T13:17:46Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-517e94373a8e404db7b5de93e9ff9be22023-05-11T12:28:44ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-05-011410.3389/fendo.2023.11578051157805Endocrine side effects of immune checkpoint inhibitorsZulma Cardona0Jeffrey A. Sosman1Sunandana Chandra2Wenyu Huang3Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDivision of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDivision of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesDivision of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United StatesImmune checkpoint inhibitors (ICIs) have increasingly been the mainstay of treatment for numerous malignancies. However, due to their association with autoimmunity, ICIs have resulted in a variety of side effects that involve multiple organs including the endocrine system. In this review article, we describe our current understanding of the autoimmune endocrinopathies as a result of the use of ICIs. We will review the epidemiology, pathophysiology, clinical presentation, diagnosis, and management of the most commonly encountered endocrinopathies, including thyroiditis, hypophysitis, Type 1 diabetes, adrenalitis, and central diabetes insipidus.https://www.frontiersin.org/articles/10.3389/fendo.2023.1157805/fullimmune checkpoint inhibitor (ICI)endocrine side effectshypophysitisthyroiditistype1 diabetesadrenalitis |
| spellingShingle | Zulma Cardona Jeffrey A. Sosman Sunandana Chandra Wenyu Huang Endocrine side effects of immune checkpoint inhibitors Frontiers in Endocrinology immune checkpoint inhibitor (ICI) endocrine side effects hypophysitis thyroiditis type1 diabetes adrenalitis |
| title | Endocrine side effects of immune checkpoint inhibitors |
| title_full | Endocrine side effects of immune checkpoint inhibitors |
| title_fullStr | Endocrine side effects of immune checkpoint inhibitors |
| title_full_unstemmed | Endocrine side effects of immune checkpoint inhibitors |
| title_short | Endocrine side effects of immune checkpoint inhibitors |
| title_sort | endocrine side effects of immune checkpoint inhibitors |
| topic | immune checkpoint inhibitor (ICI) endocrine side effects hypophysitis thyroiditis type1 diabetes adrenalitis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1157805/full |
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