Comparison and Evaluation of Current Animal Models for Perineural Scar Formation in Rat
Objective (s): Scar formation in injured peripheral nerve bed causes several consequences which impede the process of nerve regeneration. Several animal models are used for scar induction in preclinical studies which target prevention and/or suppression of perineural scar. This study evaluates the...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2013-07-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/pdf_1129_40c824976d9bebd62394024d7a338831.html |
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| author | Leila O Zanjani Masoumeh Firouzi Mohammad-Hossein Nabian Mohsen Nategh Vafa Rahimi-Movaghar Reza S Kamrani |
| author_facet | Leila O Zanjani Masoumeh Firouzi Mohammad-Hossein Nabian Mohsen Nategh Vafa Rahimi-Movaghar Reza S Kamrani |
| author_sort | Leila O Zanjani |
| collection | DOAJ |
| description | Objective (s):
Scar formation in injured peripheral nerve bed causes several consequences which impede the process of nerve regeneration. Several animal models are used for scar induction in preclinical studies which target prevention and/or suppression of perineural scar. This study evaluates the translational capacity of four of physical injury models to induce scar formation around the sciatic nerve of rat: laceration, crush, mince and burn.
Materials and Methods:
Functional (Toe out angle), macroscopic, and microscopic evaluations were performed weekly for four weeks and correlation of findings were analyzed.
Result:
While macroscopic and microscopic findings suggested a well-developed and adhesive fibrosis surrounding the sciatic nerve, functional assessment did not reveal any significant difference between control and experimental groups (P>0.05).
Conclusion:
Our study suggests that none of the applied animal models reproduce all essential features of clinical perineural scar formation. Therefore, more studies are needed to develop optimal animal models for translating preclinical investigations |
| first_indexed | 2024-12-12T05:29:31Z |
| format | Article |
| id | doaj.art-51806fb39a9d46ec81cd00aa679a48f1 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-12T05:29:31Z |
| publishDate | 2013-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-51806fb39a9d46ec81cd00aa679a48f12022-12-22T00:36:21ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742013-07-011678868901129Comparison and Evaluation of Current Animal Models for Perineural Scar Formation in RatLeila O Zanjani0Masoumeh Firouzi1Mohammad-Hossein Nabian2Mohsen Nategh3Vafa Rahimi-Movaghar4Reza S Kamrani5Tissue Repair Lab, Institute of Biochemistry and Biophysics, University of Tehran, Tehran IranTissue Repair Lab, Institute of Biochemistry and Biophysics, University of Tehran, Tehran Iran 2 Research Center for Neural Repair, University of Tehran, Tehran, IraTissue Repair Lab, Institute of Biochemistry and Biophysics, University of Tehran, Tehran IranTissue Repair Lab, Institute of Biochemistry and Biophysics, University of Tehran, Tehran IranResearch Center for Neural Repair, University of Tehran, Tehran, Iran.Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Orthopedics and Trauma Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranObjective (s): Scar formation in injured peripheral nerve bed causes several consequences which impede the process of nerve regeneration. Several animal models are used for scar induction in preclinical studies which target prevention and/or suppression of perineural scar. This study evaluates the translational capacity of four of physical injury models to induce scar formation around the sciatic nerve of rat: laceration, crush, mince and burn. Materials and Methods: Functional (Toe out angle), macroscopic, and microscopic evaluations were performed weekly for four weeks and correlation of findings were analyzed. Result: While macroscopic and microscopic findings suggested a well-developed and adhesive fibrosis surrounding the sciatic nerve, functional assessment did not reveal any significant difference between control and experimental groups (P>0.05). Conclusion: Our study suggests that none of the applied animal models reproduce all essential features of clinical perineural scar formation. Therefore, more studies are needed to develop optimal animal models for translating preclinical investigationshttp://ijbms.mums.ac.ir/pdf_1129_40c824976d9bebd62394024d7a338831.htmlScar Sciatic nerve Translational research |
| spellingShingle | Leila O Zanjani Masoumeh Firouzi Mohammad-Hossein Nabian Mohsen Nategh Vafa Rahimi-Movaghar Reza S Kamrani Comparison and Evaluation of Current Animal Models for Perineural Scar Formation in Rat Iranian Journal of Basic Medical Sciences Scar Sciatic nerve Translational research |
| title | Comparison and Evaluation of Current Animal Models for Perineural Scar Formation in Rat |
| title_full | Comparison and Evaluation of Current Animal Models for Perineural Scar Formation in Rat |
| title_fullStr | Comparison and Evaluation of Current Animal Models for Perineural Scar Formation in Rat |
| title_full_unstemmed | Comparison and Evaluation of Current Animal Models for Perineural Scar Formation in Rat |
| title_short | Comparison and Evaluation of Current Animal Models for Perineural Scar Formation in Rat |
| title_sort | comparison and evaluation of current animal models for perineural scar formation in rat |
| topic | Scar Sciatic nerve Translational research |
| url | http://ijbms.mums.ac.ir/pdf_1129_40c824976d9bebd62394024d7a338831.html |
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