A Novel Model Using AAV9-Cre to Knockout Adult Leydig Cell Gene Expression Reveals a Physiological Role of Glucocorticoid Receptor Signalling in Leydig Cell Function

A Novel Model Using AAV9-Cre to Knockout Adult Leydig Cell Gene Expression Reveals a Physiological Role of Glucocorticoid Receptor Signalling in Leydig Cell Function

Glucocorticoids are steroids involved in key physiological processes such as development, metabolism, inflammatory and stress responses and are mostly used exogenously as medications to treat various inflammation-based conditions. They act via the glucocorticoid receptor (GR) expressed in most cells...

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Bibliographic Details
Main Authors: Anne-Louise Gannon, Annalucia L. Darbey, Grace Chensee, Ben M. Lawrence, Liza O’Donnell, Joanna Kelso, Natalie Reed, Shanmathi Parameswaran, Sarah Smith, Lee B. Smith, Diane Rebourcet
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
glucocorticoid receptor
androgens
leydig cells
AAV9
steroidogenesis
Online Access:https://www.mdpi.com/1422-0067/23/23/15015

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