Mixed pathologies mimicking motor neuron disease: a case report and review of the literature
Amyotrophic lateral sclerosis (ALS) is classified as a motor neuron disease (MND) that can present with both upper and lower motor neuron signs. Concurrent ALS and frontotemporal dementia (FTD) is also a well-known phenomenon. Examples of other primary disorders mimicking ALS or ALS-FTD have been re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2021-12-01
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| Series: | Folia Neuropathologica |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Mixed-pathologies-mimicking-motor-neuron-disease-a-case-report-and-review-of-the-literature,20,45796,1,1.html |
| _version_ | 1817985154275082240 |
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| author | Avyarthana Dey Ekhlas Assaedi Wendy Johnston Sanjay Kalra Sumit Das |
| author_facet | Avyarthana Dey Ekhlas Assaedi Wendy Johnston Sanjay Kalra Sumit Das |
| author_sort | Avyarthana Dey |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is classified as a motor neuron disease (MND) that can present with both upper and lower motor neuron signs. Concurrent ALS and frontotemporal dementia (FTD) is also a well-known phenomenon. Examples of other primary disorders mimicking ALS or ALS-FTD have been reported in the literature and recognition of these entities is important to ensure proper clinical management. We present here an unusual case of an 86-year-old male patient, clinically diagnosed with ALS and severe cognitive impairment thought to be due to FTD. Postmortem neuropathological examination of his brain and spinal cord did not reveal the typical findings of ALS or FTD. Rather, it revealed multiple non-ALS pathologies including argyrophilic grain disease (AGD), cerebrovascular disease, and Alzheimer’s type pathology. This case raises the possibility that mixed pathologies could mimic motor neuron disease. |
| first_indexed | 2024-04-13T23:53:38Z |
| format | Article |
| id | doaj.art-51837b6a75ff4d73bffe1e87b89da5fe |
| institution | Directory Open Access Journal |
| issn | 1641-4640 1509-572X |
| language | English |
| last_indexed | 2024-04-13T23:53:38Z |
| publishDate | 2021-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Folia Neuropathologica |
| spelling | doaj.art-51837b6a75ff4d73bffe1e87b89da5fe2022-12-22T02:23:59ZengTermedia Publishing HouseFolia Neuropathologica1641-46401509-572X2021-12-0159440340810.5114/fn.2021.11148645796Mixed pathologies mimicking motor neuron disease: a case report and review of the literatureAvyarthana DeyEkhlas AssaediWendy JohnstonSanjay KalraSumit DasAmyotrophic lateral sclerosis (ALS) is classified as a motor neuron disease (MND) that can present with both upper and lower motor neuron signs. Concurrent ALS and frontotemporal dementia (FTD) is also a well-known phenomenon. Examples of other primary disorders mimicking ALS or ALS-FTD have been reported in the literature and recognition of these entities is important to ensure proper clinical management. We present here an unusual case of an 86-year-old male patient, clinically diagnosed with ALS and severe cognitive impairment thought to be due to FTD. Postmortem neuropathological examination of his brain and spinal cord did not reveal the typical findings of ALS or FTD. Rather, it revealed multiple non-ALS pathologies including argyrophilic grain disease (AGD), cerebrovascular disease, and Alzheimer’s type pathology. This case raises the possibility that mixed pathologies could mimic motor neuron disease.https://www.termedia.pl/Mixed-pathologies-mimicking-motor-neuron-disease-a-case-report-and-review-of-the-literature,20,45796,1,1.htmlamyotrophic lateral sclerosis argyrophilic grain disease cerebrovascular alzheimer’s neuropathology overlap |
| spellingShingle | Avyarthana Dey Ekhlas Assaedi Wendy Johnston Sanjay Kalra Sumit Das Mixed pathologies mimicking motor neuron disease: a case report and review of the literature Folia Neuropathologica amyotrophic lateral sclerosis argyrophilic grain disease cerebrovascular alzheimer’s neuropathology overlap |
| title | Mixed pathologies mimicking motor neuron disease: a case report and review of the literature |
| title_full | Mixed pathologies mimicking motor neuron disease: a case report and review of the literature |
| title_fullStr | Mixed pathologies mimicking motor neuron disease: a case report and review of the literature |
| title_full_unstemmed | Mixed pathologies mimicking motor neuron disease: a case report and review of the literature |
| title_short | Mixed pathologies mimicking motor neuron disease: a case report and review of the literature |
| title_sort | mixed pathologies mimicking motor neuron disease a case report and review of the literature |
| topic | amyotrophic lateral sclerosis argyrophilic grain disease cerebrovascular alzheimer’s neuropathology overlap |
| url | https://www.termedia.pl/Mixed-pathologies-mimicking-motor-neuron-disease-a-case-report-and-review-of-the-literature,20,45796,1,1.html |
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