Δ9-Tetrahydrocannabinol does not upregulate an aversive dopamine receptor mechanism in adolescent brain unlike in adults

Earlier age of cannabis usage poses higher risk of Cannabis Use Disorder and adverse consequences, such as addiction, anxiety, dysphoria, psychosis, largely attributed to its principal psychoactive component, Δ9-tetrahydrocannabinol (THC) and altered dopaminergic function. As dopamine D1-D2 receptor...

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Bibliographic Details
Main Authors: Marie-Eve Di Raddo, Marija Milenkovic, Meenalochani Sivasubramanian, Ahmed Hasbi, Jack Bergman, Sarah Withey, Bertha K. Madras, Susan R. George
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Current Research in Neurobiology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2665945X23000359