The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study
ObjectivesThe aim of the present study was to evaluate the prevalence of polycystic ovary syndrome (PCOS), its phenotypical and cardio-metabolic features in a community sample of the Iranian population in comparison to healthy eumenorrheic, non-hirsute women without polycystic ovaries. The second ai...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.825528/full |
| _version_ | 1818982270847942656 |
|---|---|
| author | Mahbanoo Farhadi-Azar Samira Behboudi-Gandevani Maryam Rahmati Fatemeh Mahboobifard Fatemeh Mahboobifard Ensi Khalili Pouya Fahimeh Ramezani Tehrani Fereidoun Azizi |
| author_facet | Mahbanoo Farhadi-Azar Samira Behboudi-Gandevani Maryam Rahmati Fatemeh Mahboobifard Fatemeh Mahboobifard Ensi Khalili Pouya Fahimeh Ramezani Tehrani Fereidoun Azizi |
| author_sort | Mahbanoo Farhadi-Azar |
| collection | DOAJ |
| description | ObjectivesThe aim of the present study was to evaluate the prevalence of polycystic ovary syndrome (PCOS), its phenotypical and cardio-metabolic features in a community sample of the Iranian population in comparison to healthy eumenorrheic, non-hirsute women without polycystic ovaries. The second aim was to assess the cardio-metabolic characteristics of women who suffered from one criteria of PCOS compared to those healthy eumenorrheic, non-hirsute women.MethodsIn this cross-sectional population-based study, a total of 1,960 eligible women, aged (18–45 years) were recruited from the Tehran-Lipid and Glucose-Study participants and were classified as the three groups of (i) women with PCOS by the Rotterdam criteria, (ii) non-PCOS women with one criteria of PCOS and (iii) healthy eumenorrheic, non-hirsute women without polycystic ovaries morphology (PCOM) as the control group. Further PCOS women were extended to four phenotypes of hyperandrogenism, oligo-anovulation, polycystic ovaries (phenotype A), hyperandrogenism, oligo/anovulation (phenotype B), hyperandrogenism, polycystic ovaries (phenotype C) and oligo-anovulation, polycystic ovaries (phenotype D). Cardio-metabolic profiles and the prevalence of comorbidities of metabolic syndrome (MetS) and lipid abnormalities were compared among these groups linear, and the median regression models adjusted for age and body mass index.ResultsThe prevalence of PCOS according to the diagnostic criteria of the NIH, Rotterdam and AE-PCOS Society were 13.6, 19.4, and 17.8, respectively. Among those who met the Rotterdam criteria, 23.9, 46.3, 21.6, and 8.2% had phenotypes A, B, C, and D, respectively. Among the remaining 1,580 women who did not fulfil the PCOS criteria, 108 (6.8%) suffered from only oligo/anovulation, 332 (21%) only hyperandrogenism/hyperandrogenemia, 159 (16.2%) only PCOM in ultrasound and 981 (62%) were healthy eumenorrheic, non-hirsute women without PCOM. The study revealed that some adiposity indices and lipid abnormalities in PCOS phenotypes with hyperandrogenism (A, B, and C) were worse than in healthy women. By contrast, women with phenotype D did not differ from the healthy ones in terms of adiposity and lipid abnormalities. However, the respective values for other cardio-metabolic profiles and MetS rates in different phenotypes of PCOS were similar to the healthy women. Only the prevalence of MetS in phenotype A was significantly higher than in the healthy women. There were no statistically significant differences between participants with one criteria of PCOS and healthy counterparts in terms of most adiposity indexes, cardio-metabolic factors, and comorbidity of MetS and its components. However, women with hyperandrogenism had a significantly higher level of the waist to height ratio (WHtR) and hypertriglyceridemia than their healthy counterparts.ConclusionPCOS, mainly classical phenotypes A and B, are common among Iranian women of reproductive age. Women with PCOS who had androgen excess exhibited the worst lipid profile, and those who had full three criteria of the syndrome exhibited the higher rate of MetS. However, women with only ovulatory dysfunction and only PCOM had similar cardio-metabolic characteristics, compared to healthy subjects. These data suggest that routine screening for metabolic disturbances may be needed in the prevention of cardio-metabolic disorders in patients with more serious phenotypes of PCOS. |
| first_indexed | 2024-12-20T17:44:33Z |
| format | Article |
| id | doaj.art-5185e392e6884387a6de9fd586e71185 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-20T17:44:33Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-5185e392e6884387a6de9fd586e711852022-12-21T19:31:00ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-03-011310.3389/fendo.2022.825528825528The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose StudyMahbanoo Farhadi-Azar0Samira Behboudi-Gandevani1Maryam Rahmati2Fatemeh Mahboobifard3Fatemeh Mahboobifard4Ensi Khalili Pouya5Fahimeh Ramezani Tehrani6Fereidoun Azizi7Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranFaculty of Nursing and Health Sciences, Nord University, Bodø, NorwayReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranFaculty of Medicine, Shahid Beheshti University of Medical Science, Tehran, IranReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEndocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranObjectivesThe aim of the present study was to evaluate the prevalence of polycystic ovary syndrome (PCOS), its phenotypical and cardio-metabolic features in a community sample of the Iranian population in comparison to healthy eumenorrheic, non-hirsute women without polycystic ovaries. The second aim was to assess the cardio-metabolic characteristics of women who suffered from one criteria of PCOS compared to those healthy eumenorrheic, non-hirsute women.MethodsIn this cross-sectional population-based study, a total of 1,960 eligible women, aged (18–45 years) were recruited from the Tehran-Lipid and Glucose-Study participants and were classified as the three groups of (i) women with PCOS by the Rotterdam criteria, (ii) non-PCOS women with one criteria of PCOS and (iii) healthy eumenorrheic, non-hirsute women without polycystic ovaries morphology (PCOM) as the control group. Further PCOS women were extended to four phenotypes of hyperandrogenism, oligo-anovulation, polycystic ovaries (phenotype A), hyperandrogenism, oligo/anovulation (phenotype B), hyperandrogenism, polycystic ovaries (phenotype C) and oligo-anovulation, polycystic ovaries (phenotype D). Cardio-metabolic profiles and the prevalence of comorbidities of metabolic syndrome (MetS) and lipid abnormalities were compared among these groups linear, and the median regression models adjusted for age and body mass index.ResultsThe prevalence of PCOS according to the diagnostic criteria of the NIH, Rotterdam and AE-PCOS Society were 13.6, 19.4, and 17.8, respectively. Among those who met the Rotterdam criteria, 23.9, 46.3, 21.6, and 8.2% had phenotypes A, B, C, and D, respectively. Among the remaining 1,580 women who did not fulfil the PCOS criteria, 108 (6.8%) suffered from only oligo/anovulation, 332 (21%) only hyperandrogenism/hyperandrogenemia, 159 (16.2%) only PCOM in ultrasound and 981 (62%) were healthy eumenorrheic, non-hirsute women without PCOM. The study revealed that some adiposity indices and lipid abnormalities in PCOS phenotypes with hyperandrogenism (A, B, and C) were worse than in healthy women. By contrast, women with phenotype D did not differ from the healthy ones in terms of adiposity and lipid abnormalities. However, the respective values for other cardio-metabolic profiles and MetS rates in different phenotypes of PCOS were similar to the healthy women. Only the prevalence of MetS in phenotype A was significantly higher than in the healthy women. There were no statistically significant differences between participants with one criteria of PCOS and healthy counterparts in terms of most adiposity indexes, cardio-metabolic factors, and comorbidity of MetS and its components. However, women with hyperandrogenism had a significantly higher level of the waist to height ratio (WHtR) and hypertriglyceridemia than their healthy counterparts.ConclusionPCOS, mainly classical phenotypes A and B, are common among Iranian women of reproductive age. Women with PCOS who had androgen excess exhibited the worst lipid profile, and those who had full three criteria of the syndrome exhibited the higher rate of MetS. However, women with only ovulatory dysfunction and only PCOM had similar cardio-metabolic characteristics, compared to healthy subjects. These data suggest that routine screening for metabolic disturbances may be needed in the prevention of cardio-metabolic disorders in patients with more serious phenotypes of PCOS.https://www.frontiersin.org/articles/10.3389/fendo.2022.825528/fullcardio-metabolic disturbancesTehran Lipid and Glucose Studypolycystic ovary syndromeprevalencemetabolic syndrome |
| spellingShingle | Mahbanoo Farhadi-Azar Samira Behboudi-Gandevani Maryam Rahmati Fatemeh Mahboobifard Fatemeh Mahboobifard Ensi Khalili Pouya Fahimeh Ramezani Tehrani Fereidoun Azizi The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study Frontiers in Endocrinology cardio-metabolic disturbances Tehran Lipid and Glucose Study polycystic ovary syndrome prevalence metabolic syndrome |
| title | The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study |
| title_full | The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study |
| title_fullStr | The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study |
| title_full_unstemmed | The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study |
| title_short | The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population: Tehran Lipid and Glucose Study |
| title_sort | prevalence of polycystic ovary syndrome its phenotypes and cardio metabolic features in a community sample of iranian population tehran lipid and glucose study |
| topic | cardio-metabolic disturbances Tehran Lipid and Glucose Study polycystic ovary syndrome prevalence metabolic syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.825528/full |
| work_keys_str_mv | AT mahbanoofarhadiazar theprevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT samirabehboudigandevani theprevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT maryamrahmati theprevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT fatemehmahboobifard theprevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT fatemehmahboobifard theprevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT ensikhalilipouya theprevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT fahimehramezanitehrani theprevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT fereidounazizi theprevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT mahbanoofarhadiazar prevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT samirabehboudigandevani prevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT maryamrahmati prevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT fatemehmahboobifard prevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT fatemehmahboobifard prevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT ensikhalilipouya prevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT fahimehramezanitehrani prevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy AT fereidounazizi prevalenceofpolycysticovarysyndromeitsphenotypesandcardiometabolicfeaturesinacommunitysampleofiranianpopulationtehranlipidandglucosestudy |