The Value of Percutaneous Contrast-Enhanced Ultrasound in the Evaluation of Sentinel Lymph Node of Breast Cancer
Objective: To analysis breast cancer sentinel lymph channels (SLCs) and the shape of the sentinel lymph nodes (SLNs) perfusion by contrast-enhanced ultrasound (CEUS) and to explore its value in the diagnosis of sentinel metastasis lymph nodes. Methods: A retrospective analysis, 66 breast cancer pati...
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| Format: | Article |
| Language: | English |
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Editorial Office of Advanced Ultrasound in Diagnosis and Therapy
2018-08-01
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| Series: | Advanced Ultrasound in Diagnosis and Therapy |
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| Online Access: | http://www.journaladvancedultrasound.com:81/fileup/2576-2516/PDF/1534732215274-1985650208.pdf |
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| author | Ping Wang, MM, Jian Liu, MD, Wensheng Yue, MM, Wenyan Li, MM, Yuqun Luo, MM, Jiao He, MM |
| author_facet | Ping Wang, MM, Jian Liu, MD, Wensheng Yue, MM, Wenyan Li, MM, Yuqun Luo, MM, Jiao He, MM |
| author_sort | Ping Wang, MM, Jian Liu, MD, Wensheng Yue, MM, Wenyan Li, MM, Yuqun Luo, MM, Jiao He, MM |
| collection | DOAJ |
| description | Objective: To analysis breast cancer sentinel lymph channels (SLCs) and the shape of the sentinel lymph nodes (SLNs) perfusion by contrast-enhanced ultrasound (CEUS) and to explore its value in the diagnosis of sentinel metastasis lymph nodes. Methods: A retrospective analysis, 66 breast cancer patients with 101 ipsilateral axillary SLNs checking by CEUS, was confirmed by pathology. SLCs and SLNs positions were marked and then the rough needle biopsy pathology was used to confirm the benign or malignant SLNs. According to the different perfusion, SLNs were divided into five groups and evaluated by scores. MecNemar test and receiver operating characteristic (ROC) curve were used to analyze the statistical analysis. The difference of p < 0.05 was statistically significant. The cut-off value was finally determined, and the results of ultrasound screening test were evaluated. Results: A total of 66 patients with 101 SLNs were successfully evaluated, including 42 cases of metastatic lymph nodes, and 59 cases of benign lymph nodes. The area under the ROC curve was 0.752 (p < 0.05). To ROC curve, the cut off value was 3.5. The scores 4 and 5 of lymph nodes were negative, and scores 1, 2, 3 of lymph nodes were positive. The sensitivity, specificity, false negative rate, false positive rate, and the coincidence rate of the screening test were 44.19%, 93.10%, 55.81%, 6.9%, 72.28% respectively. The value of positive predictive and the negative predictive were 82.61%, 69.23% respectively. Conclusion: To evaluate SLCs shape and judge benign and malignant SLNs, percutaneous CEUS has a high practical value. |
| first_indexed | 2024-12-14T19:05:13Z |
| format | Article |
| id | doaj.art-5187297ccb6746fca717bfa7f922cfc2 |
| institution | Directory Open Access Journal |
| issn | 2576-2516 |
| language | English |
| last_indexed | 2024-12-14T19:05:13Z |
| publishDate | 2018-08-01 |
| publisher | Editorial Office of Advanced Ultrasound in Diagnosis and Therapy |
| record_format | Article |
| series | Advanced Ultrasound in Diagnosis and Therapy |
| spelling | doaj.art-5187297ccb6746fca717bfa7f922cfc22022-12-21T22:50:52ZengEditorial Office of Advanced Ultrasound in Diagnosis and TherapyAdvanced Ultrasound in Diagnosis and Therapy2576-25162018-08-012211311810.37015/AUDT.2018.180808The Value of Percutaneous Contrast-Enhanced Ultrasound in the Evaluation of Sentinel Lymph Node of Breast CancerPing Wang, MM, Jian Liu, MD, Wensheng Yue, MM, Wenyan Li, MM, Yuqun Luo, MM, Jiao He, MM0Department of Ultrasound, The Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaObjective: To analysis breast cancer sentinel lymph channels (SLCs) and the shape of the sentinel lymph nodes (SLNs) perfusion by contrast-enhanced ultrasound (CEUS) and to explore its value in the diagnosis of sentinel metastasis lymph nodes. Methods: A retrospective analysis, 66 breast cancer patients with 101 ipsilateral axillary SLNs checking by CEUS, was confirmed by pathology. SLCs and SLNs positions were marked and then the rough needle biopsy pathology was used to confirm the benign or malignant SLNs. According to the different perfusion, SLNs were divided into five groups and evaluated by scores. MecNemar test and receiver operating characteristic (ROC) curve were used to analyze the statistical analysis. The difference of p < 0.05 was statistically significant. The cut-off value was finally determined, and the results of ultrasound screening test were evaluated. Results: A total of 66 patients with 101 SLNs were successfully evaluated, including 42 cases of metastatic lymph nodes, and 59 cases of benign lymph nodes. The area under the ROC curve was 0.752 (p < 0.05). To ROC curve, the cut off value was 3.5. The scores 4 and 5 of lymph nodes were negative, and scores 1, 2, 3 of lymph nodes were positive. The sensitivity, specificity, false negative rate, false positive rate, and the coincidence rate of the screening test were 44.19%, 93.10%, 55.81%, 6.9%, 72.28% respectively. The value of positive predictive and the negative predictive were 82.61%, 69.23% respectively. Conclusion: To evaluate SLCs shape and judge benign and malignant SLNs, percutaneous CEUS has a high practical value.http://www.journaladvancedultrasound.com:81/fileup/2576-2516/PDF/1534732215274-1985650208.pdf|breast cancer|contrast ultrasound|slns|needle biopsy |
| spellingShingle | Ping Wang, MM, Jian Liu, MD, Wensheng Yue, MM, Wenyan Li, MM, Yuqun Luo, MM, Jiao He, MM The Value of Percutaneous Contrast-Enhanced Ultrasound in the Evaluation of Sentinel Lymph Node of Breast Cancer Advanced Ultrasound in Diagnosis and Therapy |breast cancer|contrast ultrasound|slns|needle biopsy |
| title | The Value of Percutaneous Contrast-Enhanced Ultrasound in the Evaluation of Sentinel Lymph Node of Breast Cancer |
| title_full | The Value of Percutaneous Contrast-Enhanced Ultrasound in the Evaluation of Sentinel Lymph Node of Breast Cancer |
| title_fullStr | The Value of Percutaneous Contrast-Enhanced Ultrasound in the Evaluation of Sentinel Lymph Node of Breast Cancer |
| title_full_unstemmed | The Value of Percutaneous Contrast-Enhanced Ultrasound in the Evaluation of Sentinel Lymph Node of Breast Cancer |
| title_short | The Value of Percutaneous Contrast-Enhanced Ultrasound in the Evaluation of Sentinel Lymph Node of Breast Cancer |
| title_sort | value of percutaneous contrast enhanced ultrasound in the evaluation of sentinel lymph node of breast cancer |
| topic | |breast cancer|contrast ultrasound|slns|needle biopsy |
| url | http://www.journaladvancedultrasound.com:81/fileup/2576-2516/PDF/1534732215274-1985650208.pdf |
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