HLA-G5 and G7 Isoforms in Pregnant Women
Human leukocyte antigen-G which is an immune tolerance effecter molecule has an important role in the maintenance of fetus during pregnancy. Abortion is one of the complications of pregnancy period. In this research, we have studied levels of HLA-G 5, HLA-G7 isoforms in the abortion-threatened preg...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2015-04-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/392 |
| _version_ | 1828463191817977856 |
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| author | Saeid Abediankenari Faramars Farzad Zahra Rahmani Mohammad Bagher Hashemi-Soteh |
| author_facet | Saeid Abediankenari Faramars Farzad Zahra Rahmani Mohammad Bagher Hashemi-Soteh |
| author_sort | Saeid Abediankenari |
| collection | DOAJ |
| description | Human leukocyte antigen-G which is an immune tolerance effecter molecule has an important role in the maintenance of fetus during pregnancy. Abortion is one of the complications of pregnancy period. In this research, we have studied levels of HLA-G 5, HLA-G7 isoforms in the abortion-threatened pregnant women in comparison with controls. In a case-control study, 101 abortion-threatened women and 101 healthy pregnant women (healthy controls) with age range 21-32 years were studied. Gene expression of HLA-5 and HLA-7 isoforms was analyzed by real-time polymerase chain reaction after mRNA extraction and cDNA synthesis. The results indicated that HLA-G5 was significantly lower in abortion-threatened women in comparison with the control group whereas HLA-G7 was not significantly differentbetween the 2 groups. HLA-G is a vital molecule during pregnancy that can be a key factor in prevention of abortion. It is concluded that determination of HLA-G5 can be of value in pregnancy. |
| first_indexed | 2024-12-11T02:49:46Z |
| format | Article |
| id | doaj.art-51873efeba8242c198c7a5b65f66049e |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-11T02:49:46Z |
| publishDate | 2015-04-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-51873efeba8242c198c7a5b65f66049e2022-12-22T01:23:19ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492015-04-01142357HLA-G5 and G7 Isoforms in Pregnant WomenSaeid Abediankenari0Faramars Farzad1Zahra Rahmani2Mohammad Bagher Hashemi-Soteh3Immunogenetic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Department of Obstetrics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Immunogenetic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.Human leukocyte antigen-G which is an immune tolerance effecter molecule has an important role in the maintenance of fetus during pregnancy. Abortion is one of the complications of pregnancy period. In this research, we have studied levels of HLA-G 5, HLA-G7 isoforms in the abortion-threatened pregnant women in comparison with controls. In a case-control study, 101 abortion-threatened women and 101 healthy pregnant women (healthy controls) with age range 21-32 years were studied. Gene expression of HLA-5 and HLA-7 isoforms was analyzed by real-time polymerase chain reaction after mRNA extraction and cDNA synthesis. The results indicated that HLA-G5 was significantly lower in abortion-threatened women in comparison with the control group whereas HLA-G7 was not significantly differentbetween the 2 groups. HLA-G is a vital molecule during pregnancy that can be a key factor in prevention of abortion. It is concluded that determination of HLA-G5 can be of value in pregnancy.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/392AbortionHLA-GPregnancy |
| spellingShingle | Saeid Abediankenari Faramars Farzad Zahra Rahmani Mohammad Bagher Hashemi-Soteh HLA-G5 and G7 Isoforms in Pregnant Women Iranian Journal of Allergy, Asthma and Immunology Abortion HLA-G Pregnancy |
| title | HLA-G5 and G7 Isoforms in Pregnant Women |
| title_full | HLA-G5 and G7 Isoforms in Pregnant Women |
| title_fullStr | HLA-G5 and G7 Isoforms in Pregnant Women |
| title_full_unstemmed | HLA-G5 and G7 Isoforms in Pregnant Women |
| title_short | HLA-G5 and G7 Isoforms in Pregnant Women |
| title_sort | hla g5 and g7 isoforms in pregnant women |
| topic | Abortion HLA-G Pregnancy |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/392 |
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