Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection
BACKGROUND Congenital cytomegalovirus (cCMV) infections are the leading nongenetic cause of congenital sensorineural hearing loss (SNHL); however the true impact of cCMV infections remains unknown. AIMS OF THE STUDY (1) To identify the number of as...
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| Format: | Article |
| Language: | English |
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SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
2018-06-01
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| Series: | Swiss Medical Weekly |
| Subjects: | |
| Online Access: | https://www.smw.ch/index.php/smw/article/view/2482 |
| _version_ | 1826995893804466176 |
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| author | Manuela Kobas Myriam Bickle Graz Anita Carmen Truttmann Eric Giannoni Pascal Meylan Sandra Andrea Asner |
| author_facet | Manuela Kobas Myriam Bickle Graz Anita Carmen Truttmann Eric Giannoni Pascal Meylan Sandra Andrea Asner |
| author_sort | Manuela Kobas |
| collection | DOAJ |
| description |
BACKGROUND
Congenital cytomegalovirus (cCMV) infections are the leading nongenetic cause of congenital sensorineural hearing loss (SNHL); however the true impact of cCMV infections remains unknown.
AIMS OF THE STUDY
(1) To identify the number of asymptomatic and symptomatic cCMV infections diagnosed between 1999 and 2014 at the Lausanne University Hospital; (2) to describe the audiological and neurodevelopmental outcomes of infants with cCMV infection; and (3) to compare clinical outcomes between infants born to mothers with primary versus nonprimary infection.
METHODS
This was a single-centre, observational, exploratory, retrospective study of newborns diagnosed with cCMV infection at the Lausanne University Hospital between 1999 and 2014.
RESULTS
Fifty newborns with cCMV infection were identified; 39 (78%) were symptomatic at birth, of whom 29 (74%) were neurologically symptomatic. Twelve children (24%) presented with subsequent abnormal audiological and/or neurodevelopmental outcomes. Newborns born to mothers with a nonprimary infection were more often symptomatic at birth than those born to mothers with a primary infection.
CONCLUSIONS
All infants with subsequent SNHL or abnormal neurodevelopment were symptomatic at birth. Similar long-term neurodevelopmental and audiological outcomes were observed in infants born to mothers with a primary and nonprimary infection.
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| first_indexed | 2024-04-13T03:38:01Z |
| format | Article |
| id | doaj.art-51887fb8e8b34d918411909000fa0973 |
| institution | Directory Open Access Journal |
| issn | 1424-3997 |
| language | English |
| last_indexed | 2025-02-18T09:39:49Z |
| publishDate | 2018-06-01 |
| publisher | SMW supporting association (Trägerverein Swiss Medical Weekly SMW) |
| record_format | Article |
| series | Swiss Medical Weekly |
| spelling | doaj.art-51887fb8e8b34d918411909000fa09732024-11-02T17:26:19ZengSMW supporting association (Trägerverein Swiss Medical Weekly SMW)Swiss Medical Weekly1424-39972018-06-01148232410.4414/smw.2018.14627Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infectionManuela Kobas0Myriam Bickle Graz1Anita Carmen Truttmann2Eric Giannoni3Pascal Meylan4Sandra Andrea Asner5Faculty of Biology and Medicine, University of Lausanne, SwitzerlandFollow-up Unit, Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital, Switzerland; Clinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital, SwitzerlandClinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital, SwitzerlandClinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital, SwitzerlandInstitute of Microbiology, Department of Laboratories, Lausanne University Hospital, Switzerland; Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, SwitzerlandInfectious Diseases Service, Department of Medicine, Lausanne University Hospital, Switzerland; Paediatric Infectious Diseases and Vaccinology Unit, Department Woman-Mother-Child, Lausanne University Hospital, Switzerland BACKGROUND Congenital cytomegalovirus (cCMV) infections are the leading nongenetic cause of congenital sensorineural hearing loss (SNHL); however the true impact of cCMV infections remains unknown. AIMS OF THE STUDY (1) To identify the number of asymptomatic and symptomatic cCMV infections diagnosed between 1999 and 2014 at the Lausanne University Hospital; (2) to describe the audiological and neurodevelopmental outcomes of infants with cCMV infection; and (3) to compare clinical outcomes between infants born to mothers with primary versus nonprimary infection. METHODS This was a single-centre, observational, exploratory, retrospective study of newborns diagnosed with cCMV infection at the Lausanne University Hospital between 1999 and 2014. RESULTS Fifty newborns with cCMV infection were identified; 39 (78%) were symptomatic at birth, of whom 29 (74%) were neurologically symptomatic. Twelve children (24%) presented with subsequent abnormal audiological and/or neurodevelopmental outcomes. Newborns born to mothers with a nonprimary infection were more often symptomatic at birth than those born to mothers with a primary infection. CONCLUSIONS All infants with subsequent SNHL or abnormal neurodevelopment were symptomatic at birth. Similar long-term neurodevelopmental and audiological outcomes were observed in infants born to mothers with a primary and nonprimary infection. https://www.smw.ch/index.php/smw/article/view/2482congenital CMV infectionsensorineural hearing lossneurodevelopmentprimary infectionnonprimary infection |
| spellingShingle | Manuela Kobas Myriam Bickle Graz Anita Carmen Truttmann Eric Giannoni Pascal Meylan Sandra Andrea Asner Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection Swiss Medical Weekly congenital CMV infection sensorineural hearing loss neurodevelopment primary infection nonprimary infection |
| title | Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection |
| title_full | Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection |
| title_fullStr | Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection |
| title_full_unstemmed | Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection |
| title_short | Clinical characteristics, audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection |
| title_sort | clinical characteristics audiological and neurodevelopmental outcomes of newborns with congenital cytomegalovirus infection |
| topic | congenital CMV infection sensorineural hearing loss neurodevelopment primary infection nonprimary infection |
| url | https://www.smw.ch/index.php/smw/article/view/2482 |
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