Preclinical Evaluation of a Novel High-Affinity Radioligand [<sup>99m</sup>Tc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)

Preclinical Evaluation of a Novel High-Affinity Radioligand [<sup>99m</sup>Tc]Tc-BQ0413 Targeting Prostate-Specific Membrane Antigen (PSMA)

Radionuclide imaging using radiolabeled inhibitors of prostate-specific membrane antigen (PSMA) can be used for the staging of prostate cancer. Previously, we optimized the Glu-urea-Lys binding moiety using a linker structure containing 2-napththyl-L-alanine and L-tyrosine. We have now designed a mo...

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Bibliographic Details
Main Authors: Ekaterina Bezverkhniaia, Panagiotis Kanellopoulos, Ayman Abouzayed, Mariia Larkina, Maryam Oroujeni, Anzhelika Vorobyeva, Ulrika Rosenström, Vladimir Tolmachev, Anna Orlova
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
prostate cancer
prostate-specific membrane antigen
PSMA
technetium-99m
BQ0413
single-photon emission computed tomography
Online Access:https://www.mdpi.com/1422-0067/24/24/17391

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