Sugammadex: clinical development and practical use
Sugammadex is belonging to a new class of drugs: the selective relaxant binding agents. Sugammadex can reverse residual paralysis by encapsulating free circulating non depolarizing muscle relaxants. The mains advantages of sugammadex when compared with conventional anticholinesterase agents are a mu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Anesthesiologists
2013-12-01
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| Series: | Korean Journal of Anesthesiology |
| Subjects: | |
| Online Access: | http://ekja.org/upload/pdf/kjae-65-495.pdf |
| _version_ | 1818254291185434624 |
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| author | Thomas Fuchs-Buder Claude Meistelman Julien Raft |
| author_facet | Thomas Fuchs-Buder Claude Meistelman Julien Raft |
| author_sort | Thomas Fuchs-Buder |
| collection | DOAJ |
| description | Sugammadex is belonging to a new class of drugs: the selective relaxant binding agents. Sugammadex can reverse residual paralysis by encapsulating free circulating non depolarizing muscle relaxants. The mains advantages of sugammadex when compared with conventional anticholinesterase agents are a much faster recovery time and the unique ability, for the first time, to reverse rapidly and efficiently deep levels of neuromuscular blockade. However it only works for reversal of rocuronium or vecuronium-induced neuromuscular blockade. When administered 3 min after rocuronium the use of a large dose (16 mg/kg) can even reverse rocuronium significantly faster than the spontaneous recovery after succinylcholine. |
| first_indexed | 2024-12-12T16:53:38Z |
| format | Article |
| id | doaj.art-51897b8906774c2b88046b638d9d9416 |
| institution | Directory Open Access Journal |
| issn | 2005-6419 2005-7563 |
| language | English |
| last_indexed | 2024-12-12T16:53:38Z |
| publishDate | 2013-12-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Korean Journal of Anesthesiology |
| spelling | doaj.art-51897b8906774c2b88046b638d9d94162022-12-22T00:18:16ZengKorean Society of AnesthesiologistsKorean Journal of Anesthesiology2005-64192005-75632013-12-0165649550010.4097/kjae.2013.65.6.4957711Sugammadex: clinical development and practical useThomas Fuchs-Buder0Claude Meistelman1Julien Raft2Department of Anesthesiology, Centre Hospitalier Universitaire de NANCY, Hopital de Brabois, Vandoeuvre, France.Department of Anesthesiology, Centre Hospitalier Universitaire de NANCY, Hopital de Brabois, Vandoeuvre, France.Department of Anesthesiology, Centre Hospitalier Universitaire de NANCY, Hopital de Brabois, Vandoeuvre, France.Sugammadex is belonging to a new class of drugs: the selective relaxant binding agents. Sugammadex can reverse residual paralysis by encapsulating free circulating non depolarizing muscle relaxants. The mains advantages of sugammadex when compared with conventional anticholinesterase agents are a much faster recovery time and the unique ability, for the first time, to reverse rapidly and efficiently deep levels of neuromuscular blockade. However it only works for reversal of rocuronium or vecuronium-induced neuromuscular blockade. When administered 3 min after rocuronium the use of a large dose (16 mg/kg) can even reverse rocuronium significantly faster than the spontaneous recovery after succinylcholine.http://ekja.org/upload/pdf/kjae-65-495.pdfcyclodextrinsneostigmineneuromuscular blockresidual neuromuscular blockaderocuroniumsugammadex |
| spellingShingle | Thomas Fuchs-Buder Claude Meistelman Julien Raft Sugammadex: clinical development and practical use Korean Journal of Anesthesiology cyclodextrins neostigmine neuromuscular block residual neuromuscular blockade rocuronium sugammadex |
| title | Sugammadex: clinical development and practical use |
| title_full | Sugammadex: clinical development and practical use |
| title_fullStr | Sugammadex: clinical development and practical use |
| title_full_unstemmed | Sugammadex: clinical development and practical use |
| title_short | Sugammadex: clinical development and practical use |
| title_sort | sugammadex clinical development and practical use |
| topic | cyclodextrins neostigmine neuromuscular block residual neuromuscular blockade rocuronium sugammadex |
| url | http://ekja.org/upload/pdf/kjae-65-495.pdf |
| work_keys_str_mv | AT thomasfuchsbuder sugammadexclinicaldevelopmentandpracticaluse AT claudemeistelman sugammadexclinicaldevelopmentandpracticaluse AT julienraft sugammadexclinicaldevelopmentandpracticaluse |