Assessment of Specific Tumoral Markers, Inflammatory Status, and Vitamin D Metabolism before and after the First Chemotherapy Cycle in Patients with Lung Cancer
Background: We aimed to investigate the changes of inflammatory status reflected by serum levels of chitotriosidase (CHT) and neopterin, and how specific tumor markers such as neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCCA), as well as vitamin D metabolism assessed by vitami...
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MDPI AG
2022-07-01
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| Online Access: | https://www.mdpi.com/2079-7737/11/7/1033 |
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| author | Andreea Crintea Cristina Drugan Anne-Marie Constantin Iulia Lupan Zsolt Fekete Ciprian Nicolae Silaghi Alexandra Mărioara Crăciun |
| author_facet | Andreea Crintea Cristina Drugan Anne-Marie Constantin Iulia Lupan Zsolt Fekete Ciprian Nicolae Silaghi Alexandra Mărioara Crăciun |
| author_sort | Andreea Crintea |
| collection | DOAJ |
| description | Background: We aimed to investigate the changes of inflammatory status reflected by serum levels of chitotriosidase (CHT) and neopterin, and how specific tumor markers such as neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCCA), as well as vitamin D metabolism assessed by vitamin D receptor (VDR) and 25-hydroxy vitamin D<sub>3</sub> (25OHD<sub>3</sub>), were modified after the first cycle of chemotherapy in patients with lung cancer. Methods: We performed this first pilot study on twenty patients diagnosed with lung cancer by investigating the serum concentrations of CHT, neopterin, NSE, SCCA, VDR and 25OHD<sub>3</sub> before and after the first cycle of chemotherapy. Results: The post-treatment values of NSE were significantly lower compared to the pre-treatment levels (14.37 vs. 17.10 ng/mL, <i>p</i> = 0.031). We noticed a similar trend in neopterin levels, but the difference was only marginally significant (1.44 vs. 1.17 ng/mL, <i>p</i> = 0.069). On the contrary, the variations of circulating SCCA, CHT, neopterin, VDR and 25OHD<sub>3</sub>, before and after treatment, did not reach statistical significance. Conclusion: Only circulating NSE was treatment responsive to the first chemotherapy cycle in patients with lung cancer, while inflammatory markers and vitamin D status were not significantly modified. |
| first_indexed | 2024-03-09T03:41:23Z |
| format | Article |
| id | doaj.art-5189a9739eb844108c485d9ffaa96b45 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T03:41:23Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-5189a9739eb844108c485d9ffaa96b452023-12-03T14:40:38ZengMDPI AGBiology2079-77372022-07-01117103310.3390/biology11071033Assessment of Specific Tumoral Markers, Inflammatory Status, and Vitamin D Metabolism before and after the First Chemotherapy Cycle in Patients with Lung CancerAndreea Crintea0Cristina Drugan1Anne-Marie Constantin2Iulia Lupan3Zsolt Fekete4Ciprian Nicolae Silaghi5Alexandra Mărioara Crăciun6Department of Medical Biochemistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaDepartment of Medical Biochemistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaDepartment of Morphological Sciences, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaDepartment of Molecular Biology and Biotechnology, Babeș-Bolyai University, 400084 Cluj-Napoca, RomaniaDepartment of Oncology, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaDepartment of Medical Biochemistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaDepartment of Medical Biochemistry, Iuliu Hațieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, RomaniaBackground: We aimed to investigate the changes of inflammatory status reflected by serum levels of chitotriosidase (CHT) and neopterin, and how specific tumor markers such as neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCCA), as well as vitamin D metabolism assessed by vitamin D receptor (VDR) and 25-hydroxy vitamin D<sub>3</sub> (25OHD<sub>3</sub>), were modified after the first cycle of chemotherapy in patients with lung cancer. Methods: We performed this first pilot study on twenty patients diagnosed with lung cancer by investigating the serum concentrations of CHT, neopterin, NSE, SCCA, VDR and 25OHD<sub>3</sub> before and after the first cycle of chemotherapy. Results: The post-treatment values of NSE were significantly lower compared to the pre-treatment levels (14.37 vs. 17.10 ng/mL, <i>p</i> = 0.031). We noticed a similar trend in neopterin levels, but the difference was only marginally significant (1.44 vs. 1.17 ng/mL, <i>p</i> = 0.069). On the contrary, the variations of circulating SCCA, CHT, neopterin, VDR and 25OHD<sub>3</sub>, before and after treatment, did not reach statistical significance. Conclusion: Only circulating NSE was treatment responsive to the first chemotherapy cycle in patients with lung cancer, while inflammatory markers and vitamin D status were not significantly modified.https://www.mdpi.com/2079-7737/11/7/1033neuron-specific enolasesquamous cell carcinoma antigenneopterinchitotriosidasevitamin Dvitamin D receptor |
| spellingShingle | Andreea Crintea Cristina Drugan Anne-Marie Constantin Iulia Lupan Zsolt Fekete Ciprian Nicolae Silaghi Alexandra Mărioara Crăciun Assessment of Specific Tumoral Markers, Inflammatory Status, and Vitamin D Metabolism before and after the First Chemotherapy Cycle in Patients with Lung Cancer Biology neuron-specific enolase squamous cell carcinoma antigen neopterin chitotriosidase vitamin D vitamin D receptor |
| title | Assessment of Specific Tumoral Markers, Inflammatory Status, and Vitamin D Metabolism before and after the First Chemotherapy Cycle in Patients with Lung Cancer |
| title_full | Assessment of Specific Tumoral Markers, Inflammatory Status, and Vitamin D Metabolism before and after the First Chemotherapy Cycle in Patients with Lung Cancer |
| title_fullStr | Assessment of Specific Tumoral Markers, Inflammatory Status, and Vitamin D Metabolism before and after the First Chemotherapy Cycle in Patients with Lung Cancer |
| title_full_unstemmed | Assessment of Specific Tumoral Markers, Inflammatory Status, and Vitamin D Metabolism before and after the First Chemotherapy Cycle in Patients with Lung Cancer |
| title_short | Assessment of Specific Tumoral Markers, Inflammatory Status, and Vitamin D Metabolism before and after the First Chemotherapy Cycle in Patients with Lung Cancer |
| title_sort | assessment of specific tumoral markers inflammatory status and vitamin d metabolism before and after the first chemotherapy cycle in patients with lung cancer |
| topic | neuron-specific enolase squamous cell carcinoma antigen neopterin chitotriosidase vitamin D vitamin D receptor |
| url | https://www.mdpi.com/2079-7737/11/7/1033 |
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