Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model
Over the past years, promising results from studies have shown that herring milt hydrolysates (HMH) can counter immune-metabolic disorders associated with obesity. However, more studies must corroborate these results. Thus, three commercial hydrolysates (HMH1, HMH2, and HMH3) as well as the fraction...
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MDPI AG
2021-08-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/10/9/2046 |
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| author | Noémie Benoit Marie-Julie Dubois Geneviève Pilon Thibault V. Varin André Marette Laurent Bazinet |
| author_facet | Noémie Benoit Marie-Julie Dubois Geneviève Pilon Thibault V. Varin André Marette Laurent Bazinet |
| author_sort | Noémie Benoit |
| collection | DOAJ |
| description | Over the past years, promising results from studies have shown that herring milt hydrolysates (HMH) can counter immune-metabolic disorders associated with obesity. However, more studies must corroborate these results. Thus, three commercial hydrolysates (HMH1, HMH2, and HMH3) as well as the fractions of two of them (HMH4 and HMH5) obtained by electrodialysis with ultrafiltration membranes (EDUF) were evaluated <i>in vivo</i> at higher doses compared to a previous study. To achieve this, seven groups of mice were fed for 8 weeks with either a control Chow diet or an obesogenic diet rich in fat and sucrose (HFHS) and supplemented by daily gavage with water or 312.5 mg/kg of one of the five HMH products. In summary, HMH supplements had no impact on weight gain. In the insulin tolerance test (ITT), HMH2 and its HMH5 fraction significantly reduced the blood sugar variation (<i>p</i> < 0.05). However, during the glucose tolerance (OGTT), HMH2 supplement increased the hyperinsulinemia variation (<i>p</i> < 0.05) induced by the HFHS diet. HMH1, HMH2, and HMH5 supplements generated potentially beneficial changes for health in the gut microbiota. These results reveal that HMH do not counteract obesity effects but may decrease certain physiological effects induced by obesity. |
| first_indexed | 2024-03-10T07:40:32Z |
| format | Article |
| id | doaj.art-518b717704b6497dbedb2ec4c5735b69 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T07:40:32Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-518b717704b6497dbedb2ec4c5735b692023-11-22T13:03:24ZengMDPI AGFoods2304-81582021-08-01109204610.3390/foods10092046Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity ModelNoémie Benoit0Marie-Julie Dubois1Geneviève Pilon2Thibault V. Varin3André Marette4Laurent Bazinet5Laboratory of Food Processing and Electromembrane Process (LTAPEM), Department of Food Sciences, Université Laval, Québec, QC G1V 0A6, CanadaInstitute of Nutrition and Functional Foods (INAF), Université Laval, Québec, QC G1V0A6, CanadaInstitute of Nutrition and Functional Foods (INAF), Université Laval, Québec, QC G1V0A6, CanadaInstitute of Nutrition and Functional Foods (INAF), Université Laval, Québec, QC G1V0A6, CanadaInstitute of Nutrition and Functional Foods (INAF), Université Laval, Québec, QC G1V0A6, CanadaLaboratory of Food Processing and Electromembrane Process (LTAPEM), Department of Food Sciences, Université Laval, Québec, QC G1V 0A6, CanadaOver the past years, promising results from studies have shown that herring milt hydrolysates (HMH) can counter immune-metabolic disorders associated with obesity. However, more studies must corroborate these results. Thus, three commercial hydrolysates (HMH1, HMH2, and HMH3) as well as the fractions of two of them (HMH4 and HMH5) obtained by electrodialysis with ultrafiltration membranes (EDUF) were evaluated <i>in vivo</i> at higher doses compared to a previous study. To achieve this, seven groups of mice were fed for 8 weeks with either a control Chow diet or an obesogenic diet rich in fat and sucrose (HFHS) and supplemented by daily gavage with water or 312.5 mg/kg of one of the five HMH products. In summary, HMH supplements had no impact on weight gain. In the insulin tolerance test (ITT), HMH2 and its HMH5 fraction significantly reduced the blood sugar variation (<i>p</i> < 0.05). However, during the glucose tolerance (OGTT), HMH2 supplement increased the hyperinsulinemia variation (<i>p</i> < 0.05) induced by the HFHS diet. HMH1, HMH2, and HMH5 supplements generated potentially beneficial changes for health in the gut microbiota. These results reveal that HMH do not counteract obesity effects but may decrease certain physiological effects induced by obesity.https://www.mdpi.com/2304-8158/10/9/2046herring milt hydrolysatebioactive peptidesobesityglucose tolerancemicrobiota |
| spellingShingle | Noémie Benoit Marie-Julie Dubois Geneviève Pilon Thibault V. Varin André Marette Laurent Bazinet Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model Foods herring milt hydrolysate bioactive peptides obesity glucose tolerance microbiota |
| title | Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model |
| title_full | Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model |
| title_fullStr | Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model |
| title_full_unstemmed | Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model |
| title_short | Effects of Herring Milt Hydrolysates and Fractions in a Diet-Induced Obesity Model |
| title_sort | effects of herring milt hydrolysates and fractions in a diet induced obesity model |
| topic | herring milt hydrolysate bioactive peptides obesity glucose tolerance microbiota |
| url | https://www.mdpi.com/2304-8158/10/9/2046 |
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