Causal associations of COVID‐19 on neurosurgical diseases risk: a Mendelian randomization study
Abstract Many researchers have explored the potential association between one neurosurgical disease and coronavirus disease 2019 (COVID-19), but few systematically analyzed the association and causality between COVID-19 and various neurosurgical diseases. A Mendelian randomization analysis was condu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Human Genomics |
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| Online Access: | https://doi.org/10.1186/s40246-024-00575-y |
| _version_ | 1797273879289266176 |
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| author | Lirui Dai Liang Lyu Peizhi Zhou Shu Jiang |
| author_facet | Lirui Dai Liang Lyu Peizhi Zhou Shu Jiang |
| author_sort | Lirui Dai |
| collection | DOAJ |
| description | Abstract Many researchers have explored the potential association between one neurosurgical disease and coronavirus disease 2019 (COVID-19), but few systematically analyzed the association and causality between COVID-19 and various neurosurgical diseases. A Mendelian randomization analysis was conducted to evaluate the causal association between COVID-19 (including critically ill COVID‐19, hospitalized COVID‐19, and respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection) and 30 neurosurgical diseases within European populations. The consequences of inverse variance weighted models suggest that genetic susceptibility of critically ill COVID-19 may increase the risk of cerebral infarction (odds ratio [OR] = 1.02; p‐value = 0.006), genetic susceptibility of SARS-CoV-2 infection may increase the risk of stroke (OR = 1.02; p‐value = 0.047), and conversely, genetic susceptibility of hospitalized COVID-19 may reduce the risk of pituitary adenoma and craniopharyngioma (OR = 0.90; p‐value = 0.032). In addition, evidences revealed potential associations between genetic susceptibility of COVID-19 and spinal stenosis (OR = 1.03; p‐value = 0.028), diffuse brain injury (OR = 1.21; p‐value = 0.040) and focal brain injury (OR = 1.12; p‐value = 0.040). By testing for heterogeneity and pleiotropy, the above causal conclusions are robust. In summary, our analysis shows that COVID-19 has an independent and powerful causal influence on multiple neurosurgical disorders. |
| first_indexed | 2024-03-07T14:50:28Z |
| format | Article |
| id | doaj.art-518cccd13ef6456ba417e14f33d4cde4 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-03-07T14:50:28Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-518cccd13ef6456ba417e14f33d4cde42024-03-05T19:44:33ZengBMCHuman Genomics1479-73642024-02-0118111110.1186/s40246-024-00575-yCausal associations of COVID‐19 on neurosurgical diseases risk: a Mendelian randomization studyLirui Dai0Liang Lyu1Peizhi Zhou2Shu Jiang3Department of Neurosurgery, Pituitary Adenoma Multidisciplinary Center, West China Hospital of Sichuan UniversityDepartment of Neurosurgery, Pituitary Adenoma Multidisciplinary Center, West China Hospital of Sichuan UniversityDepartment of Neurosurgery, Pituitary Adenoma Multidisciplinary Center, West China Hospital of Sichuan UniversityDepartment of Neurosurgery, Pituitary Adenoma Multidisciplinary Center, West China Hospital of Sichuan UniversityAbstract Many researchers have explored the potential association between one neurosurgical disease and coronavirus disease 2019 (COVID-19), but few systematically analyzed the association and causality between COVID-19 and various neurosurgical diseases. A Mendelian randomization analysis was conducted to evaluate the causal association between COVID-19 (including critically ill COVID‐19, hospitalized COVID‐19, and respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection) and 30 neurosurgical diseases within European populations. The consequences of inverse variance weighted models suggest that genetic susceptibility of critically ill COVID-19 may increase the risk of cerebral infarction (odds ratio [OR] = 1.02; p‐value = 0.006), genetic susceptibility of SARS-CoV-2 infection may increase the risk of stroke (OR = 1.02; p‐value = 0.047), and conversely, genetic susceptibility of hospitalized COVID-19 may reduce the risk of pituitary adenoma and craniopharyngioma (OR = 0.90; p‐value = 0.032). In addition, evidences revealed potential associations between genetic susceptibility of COVID-19 and spinal stenosis (OR = 1.03; p‐value = 0.028), diffuse brain injury (OR = 1.21; p‐value = 0.040) and focal brain injury (OR = 1.12; p‐value = 0.040). By testing for heterogeneity and pleiotropy, the above causal conclusions are robust. In summary, our analysis shows that COVID-19 has an independent and powerful causal influence on multiple neurosurgical disorders.https://doi.org/10.1186/s40246-024-00575-yNeurosurgical disordersCOVID‐19Genetic variantsGenome‐wide association studyMendelian randomization |
| spellingShingle | Lirui Dai Liang Lyu Peizhi Zhou Shu Jiang Causal associations of COVID‐19 on neurosurgical diseases risk: a Mendelian randomization study Human Genomics Neurosurgical disorders COVID‐19 Genetic variants Genome‐wide association study Mendelian randomization |
| title | Causal associations of COVID‐19 on neurosurgical diseases risk: a Mendelian randomization study |
| title_full | Causal associations of COVID‐19 on neurosurgical diseases risk: a Mendelian randomization study |
| title_fullStr | Causal associations of COVID‐19 on neurosurgical diseases risk: a Mendelian randomization study |
| title_full_unstemmed | Causal associations of COVID‐19 on neurosurgical diseases risk: a Mendelian randomization study |
| title_short | Causal associations of COVID‐19 on neurosurgical diseases risk: a Mendelian randomization study |
| title_sort | causal associations of covid 19 on neurosurgical diseases risk a mendelian randomization study |
| topic | Neurosurgical disorders COVID‐19 Genetic variants Genome‐wide association study Mendelian randomization |
| url | https://doi.org/10.1186/s40246-024-00575-y |
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