Research Progress of Macromolecules in the Prevention and Treatment of Sepsis
Sepsis is associated with high rates of mortality in the intensive care unit and accompanied by systemic inflammatory reactions, secondary infections, and multiple organ failure. Biological macromolecules are drugs produced using modern biotechnology to prevent or treat diseases. Indeed, antithrombi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/16/13017 |
| _version_ | 1797584394924326912 |
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| author | Jingqian Su Shun Wu Fen Zhou Zhiyong Tong |
| author_facet | Jingqian Su Shun Wu Fen Zhou Zhiyong Tong |
| author_sort | Jingqian Su |
| collection | DOAJ |
| description | Sepsis is associated with high rates of mortality in the intensive care unit and accompanied by systemic inflammatory reactions, secondary infections, and multiple organ failure. Biological macromolecules are drugs produced using modern biotechnology to prevent or treat diseases. Indeed, antithrombin, antimicrobial peptides, interleukins, antibodies, nucleic acids, and lentinan have been used to prevent and treat sepsis. In vitro, biological macromolecules can significantly ameliorate the inflammatory response, apoptosis, and multiple organ failure caused by sepsis. Several biological macromolecules have entered clinical trials. This review summarizes the sources, efficacy, mechanism of action, and research progress of macromolecular drugs used in the prevention and treatment of sepsis. |
| first_indexed | 2024-03-10T23:51:21Z |
| format | Article |
| id | doaj.art-518d481ed5c341429756fc15e2e94c0a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:51:21Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-518d481ed5c341429756fc15e2e94c0a2023-11-19T01:34:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161301710.3390/ijms241613017Research Progress of Macromolecules in the Prevention and Treatment of SepsisJingqian Su0Shun Wu1Fen Zhou2Zhiyong Tong3Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou 350117, ChinaFujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou 350117, ChinaFujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou 350117, ChinaFujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou 350117, ChinaSepsis is associated with high rates of mortality in the intensive care unit and accompanied by systemic inflammatory reactions, secondary infections, and multiple organ failure. Biological macromolecules are drugs produced using modern biotechnology to prevent or treat diseases. Indeed, antithrombin, antimicrobial peptides, interleukins, antibodies, nucleic acids, and lentinan have been used to prevent and treat sepsis. In vitro, biological macromolecules can significantly ameliorate the inflammatory response, apoptosis, and multiple organ failure caused by sepsis. Several biological macromolecules have entered clinical trials. This review summarizes the sources, efficacy, mechanism of action, and research progress of macromolecular drugs used in the prevention and treatment of sepsis.https://www.mdpi.com/1422-0067/24/16/13017antibodybiomoleculepolypeptidepolysaccharideproteinRNA |
| spellingShingle | Jingqian Su Shun Wu Fen Zhou Zhiyong Tong Research Progress of Macromolecules in the Prevention and Treatment of Sepsis International Journal of Molecular Sciences antibody biomolecule polypeptide polysaccharide protein RNA |
| title | Research Progress of Macromolecules in the Prevention and Treatment of Sepsis |
| title_full | Research Progress of Macromolecules in the Prevention and Treatment of Sepsis |
| title_fullStr | Research Progress of Macromolecules in the Prevention and Treatment of Sepsis |
| title_full_unstemmed | Research Progress of Macromolecules in the Prevention and Treatment of Sepsis |
| title_short | Research Progress of Macromolecules in the Prevention and Treatment of Sepsis |
| title_sort | research progress of macromolecules in the prevention and treatment of sepsis |
| topic | antibody biomolecule polypeptide polysaccharide protein RNA |
| url | https://www.mdpi.com/1422-0067/24/16/13017 |
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