Evaluation of the rapid diagnostic test OptiMAL for diagnosis of malaria due to Plasmodium vivax
OBJECTIVE: To determine the sensitivity and specificity of the rapid diagnostic test OptiMAL® for diagnosis of Plasmodium vivax malaria. MATERIAL AND METHODS: We included all the patients who sought medical attention in the San Martin Pangoa Hospital, Junin, an area endemic for vivax malaria in Peru...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200005&lng=en&tlng=en |
| _version_ | 1818457394987925504 |
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| author | Alonso Soto Tarazona Lely Solari Zerpa Daniel Mendoza Requena Alejandro Llanos-Cuentas Allan Magill |
| author_facet | Alonso Soto Tarazona Lely Solari Zerpa Daniel Mendoza Requena Alejandro Llanos-Cuentas Allan Magill |
| author_sort | Alonso Soto Tarazona |
| collection | DOAJ |
| description | OBJECTIVE: To determine the sensitivity and specificity of the rapid diagnostic test OptiMAL® for diagnosis of Plasmodium vivax malaria. MATERIAL AND METHODS: We included all the patients who sought medical attention in the San Martin Pangoa Hospital, Junin, an area endemic for vivax malaria in Peru, between October and December 1998, who had fever during the previous 72 hours and who were older than 12 months. The gold standard for diagnosis was thick blood film microscopy. We determined the parasitemia rate for each of the positive slides. We calculated sensitivity, specificity, positive predictive value and negative predictive value of the test. RESULTS: We included 72 patients; 39 of them were positive for P. vivax by microscopic examination. The sensitivity of the Optimal test was 92.3%, the specificity 100%, the positive predictive value 100% and the negative predictive value 91.6%. The accuracy of the test was 95.8%. The sensitivity of the OptiMAL® test progressively decreased when parasitemia was lower than 1,000 parasites/microliter. CONCLUSIONS: the OptiMAL® test has a high sensitivity and specificity for diagnosis of P. vivax malaria. However, its sensitivity decreased when parasitemia levels were lower. It is a very simple technique, which makes it a good alternative for malaria diagnosis in remote places, although its elevated cost is still a problem. |
| first_indexed | 2024-12-14T22:41:53Z |
| format | Article |
| id | doaj.art-5191540a3d7a44eeb0e4db66616d1316 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-14T22:41:53Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-5191540a3d7a44eeb0e4db66616d13162022-12-21T22:44:58ZengElsevierBrazilian Journal of Infectious Diseases1678-43918215115510.1590/S1413-86702004000200005S1413-86702004000200005Evaluation of the rapid diagnostic test OptiMAL for diagnosis of malaria due to Plasmodium vivaxAlonso Soto Tarazona0Lely Solari Zerpa1Daniel Mendoza Requena2Alejandro Llanos-Cuentas3Allan Magill4Universidad Peruana Cayetano HerediaUniversidad Peruana Cayetano HerediaNational Health InstituteUniversidad Peruana Cayetano HerediaWalter Reed Institute of Infectious DiseasesOBJECTIVE: To determine the sensitivity and specificity of the rapid diagnostic test OptiMAL® for diagnosis of Plasmodium vivax malaria. MATERIAL AND METHODS: We included all the patients who sought medical attention in the San Martin Pangoa Hospital, Junin, an area endemic for vivax malaria in Peru, between October and December 1998, who had fever during the previous 72 hours and who were older than 12 months. The gold standard for diagnosis was thick blood film microscopy. We determined the parasitemia rate for each of the positive slides. We calculated sensitivity, specificity, positive predictive value and negative predictive value of the test. RESULTS: We included 72 patients; 39 of them were positive for P. vivax by microscopic examination. The sensitivity of the Optimal test was 92.3%, the specificity 100%, the positive predictive value 100% and the negative predictive value 91.6%. The accuracy of the test was 95.8%. The sensitivity of the OptiMAL® test progressively decreased when parasitemia was lower than 1,000 parasites/microliter. CONCLUSIONS: the OptiMAL® test has a high sensitivity and specificity for diagnosis of P. vivax malaria. However, its sensitivity decreased when parasitemia levels were lower. It is a very simple technique, which makes it a good alternative for malaria diagnosis in remote places, although its elevated cost is still a problem.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200005&lng=en&tlng=enOptiMALmalariaPlasmodium vivaxdiagnosisdipstick |
| spellingShingle | Alonso Soto Tarazona Lely Solari Zerpa Daniel Mendoza Requena Alejandro Llanos-Cuentas Allan Magill Evaluation of the rapid diagnostic test OptiMAL for diagnosis of malaria due to Plasmodium vivax Brazilian Journal of Infectious Diseases OptiMAL malaria Plasmodium vivax diagnosis dipstick |
| title | Evaluation of the rapid diagnostic test OptiMAL for diagnosis of malaria due to Plasmodium vivax |
| title_full | Evaluation of the rapid diagnostic test OptiMAL for diagnosis of malaria due to Plasmodium vivax |
| title_fullStr | Evaluation of the rapid diagnostic test OptiMAL for diagnosis of malaria due to Plasmodium vivax |
| title_full_unstemmed | Evaluation of the rapid diagnostic test OptiMAL for diagnosis of malaria due to Plasmodium vivax |
| title_short | Evaluation of the rapid diagnostic test OptiMAL for diagnosis of malaria due to Plasmodium vivax |
| title_sort | evaluation of the rapid diagnostic test optimal for diagnosis of malaria due to plasmodium vivax |
| topic | OptiMAL malaria Plasmodium vivax diagnosis dipstick |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200005&lng=en&tlng=en |
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