Plant Essential Oils Enhance Diverse Pyrethroids against Multiple Strains of Mosquitoes and Inhibit Detoxification Enzyme Processes
Mosquito-borne diseases account for the deaths of approximately 700,000 people annually throughout the world, with many more succumbing to the debilitating side effects associated with these etiologic disease agents. This is exacerbated in many countries where the lack of mosquito control and resour...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-10-01
|
| Series: | Insects |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2075-4450/9/4/132 |
| _version_ | 1818504339654705152 |
|---|---|
| author | Edmund J. Norris Jacob B. Johnson Aaron D. Gross Lyric C. Bartholomay Joel R. Coats |
| author_facet | Edmund J. Norris Jacob B. Johnson Aaron D. Gross Lyric C. Bartholomay Joel R. Coats |
| author_sort | Edmund J. Norris |
| collection | DOAJ |
| description | Mosquito-borne diseases account for the deaths of approximately 700,000 people annually throughout the world, with many more succumbing to the debilitating side effects associated with these etiologic disease agents. This is exacerbated in many countries where the lack of mosquito control and resources to prevent and treat mosquito-borne disease coincide. As populations of mosquito species grow more resistant to currently utilized control chemistries, the need for new and effective chemical means for vector control is more important than ever. Previous work revealed that plant essential oils enhance the toxicity of permethrin against multiple mosquito species that are of particular importance to public health. In this study, we screened permethrin and deltamethrin in combination with plant essential oils against a pyrethroid-susceptible and a pyrethroid-resistant strain of both Aedes aegypti and Anopheles gambiae. A number of plant essential oils significantly enhanced the toxicity of pyrethroids equal to or better than piperonyl butoxide, a commonly used synthetic synergist, in all strains tested. Significant synergism of pyrethroids was also observed for specific combinations of plant essential oils and pyrethroids. Moreover, plant essential oils significantly inhibited both cytochrome P450 and glutathione S-transferase activities, suggesting that the inhibition of detoxification contributes to the enhancement or synergism of plant essential oils for pyrethroids. This study highlights the potential of using diverse plant oils as insecticide additives to augment the efficacy of insecticidal formulations. |
| first_indexed | 2024-12-10T21:35:51Z |
| format | Article |
| id | doaj.art-51956ab7a43e4b2688ead654492d948c |
| institution | Directory Open Access Journal |
| issn | 2075-4450 |
| language | English |
| last_indexed | 2024-12-10T21:35:51Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Insects |
| spelling | doaj.art-51956ab7a43e4b2688ead654492d948c2022-12-22T01:32:39ZengMDPI AGInsects2075-44502018-10-019413210.3390/insects9040132insects9040132Plant Essential Oils Enhance Diverse Pyrethroids against Multiple Strains of Mosquitoes and Inhibit Detoxification Enzyme ProcessesEdmund J. Norris0Jacob B. Johnson1Aaron D. Gross2Lyric C. Bartholomay3Joel R. Coats4Department of Entomology, Iowa State University, Ames, IA 50011, USADepartment of Entomology, Iowa State University, Ames, IA 50011, USADepartment of Entomology, Iowa State University, Ames, IA 50011, USADepartment of Entomology, Iowa State University, Ames, IA 50011, USADepartment of Entomology, Iowa State University, Ames, IA 50011, USAMosquito-borne diseases account for the deaths of approximately 700,000 people annually throughout the world, with many more succumbing to the debilitating side effects associated with these etiologic disease agents. This is exacerbated in many countries where the lack of mosquito control and resources to prevent and treat mosquito-borne disease coincide. As populations of mosquito species grow more resistant to currently utilized control chemistries, the need for new and effective chemical means for vector control is more important than ever. Previous work revealed that plant essential oils enhance the toxicity of permethrin against multiple mosquito species that are of particular importance to public health. In this study, we screened permethrin and deltamethrin in combination with plant essential oils against a pyrethroid-susceptible and a pyrethroid-resistant strain of both Aedes aegypti and Anopheles gambiae. A number of plant essential oils significantly enhanced the toxicity of pyrethroids equal to or better than piperonyl butoxide, a commonly used synthetic synergist, in all strains tested. Significant synergism of pyrethroids was also observed for specific combinations of plant essential oils and pyrethroids. Moreover, plant essential oils significantly inhibited both cytochrome P450 and glutathione S-transferase activities, suggesting that the inhibition of detoxification contributes to the enhancement or synergism of plant essential oils for pyrethroids. This study highlights the potential of using diverse plant oils as insecticide additives to augment the efficacy of insecticidal formulations.http://www.mdpi.com/2075-4450/9/4/132mosquitoplant essential oiltoxicologyresistancesynergism |
| spellingShingle | Edmund J. Norris Jacob B. Johnson Aaron D. Gross Lyric C. Bartholomay Joel R. Coats Plant Essential Oils Enhance Diverse Pyrethroids against Multiple Strains of Mosquitoes and Inhibit Detoxification Enzyme Processes Insects mosquito plant essential oil toxicology resistance synergism |
| title | Plant Essential Oils Enhance Diverse Pyrethroids against Multiple Strains of Mosquitoes and Inhibit Detoxification Enzyme Processes |
| title_full | Plant Essential Oils Enhance Diverse Pyrethroids against Multiple Strains of Mosquitoes and Inhibit Detoxification Enzyme Processes |
| title_fullStr | Plant Essential Oils Enhance Diverse Pyrethroids against Multiple Strains of Mosquitoes and Inhibit Detoxification Enzyme Processes |
| title_full_unstemmed | Plant Essential Oils Enhance Diverse Pyrethroids against Multiple Strains of Mosquitoes and Inhibit Detoxification Enzyme Processes |
| title_short | Plant Essential Oils Enhance Diverse Pyrethroids against Multiple Strains of Mosquitoes and Inhibit Detoxification Enzyme Processes |
| title_sort | plant essential oils enhance diverse pyrethroids against multiple strains of mosquitoes and inhibit detoxification enzyme processes |
| topic | mosquito plant essential oil toxicology resistance synergism |
| url | http://www.mdpi.com/2075-4450/9/4/132 |
| work_keys_str_mv | AT edmundjnorris plantessentialoilsenhancediversepyrethroidsagainstmultiplestrainsofmosquitoesandinhibitdetoxificationenzymeprocesses AT jacobbjohnson plantessentialoilsenhancediversepyrethroidsagainstmultiplestrainsofmosquitoesandinhibitdetoxificationenzymeprocesses AT aarondgross plantessentialoilsenhancediversepyrethroidsagainstmultiplestrainsofmosquitoesandinhibitdetoxificationenzymeprocesses AT lyriccbartholomay plantessentialoilsenhancediversepyrethroidsagainstmultiplestrainsofmosquitoesandinhibitdetoxificationenzymeprocesses AT joelrcoats plantessentialoilsenhancediversepyrethroidsagainstmultiplestrainsofmosquitoesandinhibitdetoxificationenzymeprocesses |