Biomarker tools to design clinical vaccines determined from a study of annual listeriosis incidence in northern Spain

Biomarker tools to design clinical vaccines determined from a study of annual listeriosis incidence in northern Spain

Two regions of northern Spain, Gipuzkoa and Cantabria present high annual incidence of listeriosis (1.86 and 1.71 cases per 100,000 inhabitants, respectively). We report that the high annual incidences are a consequence of infection with highly virulent L. monocytogenes isolates linked to fatal outc...

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Bibliographic Details
Main Authors: Ricardo Calderón González, Hector Teran-Navarro, Jose Maria Marimon, Claudia Gonzalez-Rico, Jorge Calvo-Montes, Elisabet Frande Cabanes, Miriam Alkorta-Gurrutxaga, Carmen Fariñas, Luis Martinez-Martinez, Emilio Perez-Trallero, Carmen Alvarez-Dominguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Infection Control
Listeria
Listeriosis
Zoonoses
Vaccines Carrier
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00541/full
Description
Summary:Two regions of northern Spain, Gipuzkoa and Cantabria present high annual incidence of listeriosis (1.86 and 1.71 cases per 100,000 inhabitants, respectively). We report that the high annual incidences are a consequence of infection with highly virulent L. monocytogenes isolates linked to fatal outcomes in elderly patients with cancer. In addition, listeriosis patients with cancer present low IL-17A/IL-6 ratios and significantly reduced levels of anti-GAPDH1-22 antibodies, identified as two novel biomarkers of poor prognosis. Analysis of these biomarkers may aid in reducing the incidence of listeriosis. Moreover, GAPDH1-22 activated monocyte derived dendritic cells of listeriosis patients with cancer seem useful tools to prepare clinical vaccines as they produce mainly Th1 cytokines.
ISSN:1664-3224

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