<i>Crocodylus porosus</i> Sera a Potential Source to Identify Novel Epigenetic Targets: In Silico Analysis
We have previously found that sera from <i>Crocodylus porosus</i> contain anticancer agents and the treatment of MCF7 cells with this serum resulted in the differential expression of 51 genes. The purpose of this study was to use in silico analysis to identify genes that might be epigene...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/5/210 |
| _version_ | 1797494714817052672 |
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| author | Ruqaiyyah Siddiqui Jibran Sualeh Muhammad Sutherland K. Maciver Naveed Ahmed Khan |
| author_facet | Ruqaiyyah Siddiqui Jibran Sualeh Muhammad Sutherland K. Maciver Naveed Ahmed Khan |
| author_sort | Ruqaiyyah Siddiqui |
| collection | DOAJ |
| description | We have previously found that sera from <i>Crocodylus porosus</i> contain anticancer agents and the treatment of MCF7 cells with this serum resulted in the differential expression of 51 genes. The purpose of this study was to use in silico analysis to identify genes that might be epigenetically modulated in cells treated with crocodile serum and to understand the role of potential genes as novel candidates with epigenetic therapeutic potential. The findings report five proto-oncogenes (<i>TUBA1B</i>, <i>SLC2A1</i>, <i>PGK1</i>, <i>CCND1</i>, and <i>NCAPD2</i>) and two tumor suppressor genes (<i>RPLP2</i>, <i>RPL37</i>) as novel therapeutic targets. Furthermore, we present a comprehensive overview of relevant studies on epigenetic regulation of these genes along with an insight into their clinical implications. Therefore, elucidating the molecules present in the serum and gut bacteria of reptiles such as crocodiles may offer insights into the role of these genes on longevity, health, disease, and life expectancy. |
| first_indexed | 2024-03-10T01:38:20Z |
| format | Article |
| id | doaj.art-5197417f4df5415898a8872b1f5d8d7e |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-10T01:38:20Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-5197417f4df5415898a8872b1f5d8d7e2023-11-23T13:28:15ZengMDPI AGVeterinary Sciences2306-73812022-04-019521010.3390/vetsci9050210<i>Crocodylus porosus</i> Sera a Potential Source to Identify Novel Epigenetic Targets: In Silico AnalysisRuqaiyyah Siddiqui0Jibran Sualeh Muhammad1Sutherland K. Maciver2Naveed Ahmed Khan3College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab EmiratesDepartment of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab EmiratesCentre for Discovery Brain Science, Edinburgh Medical School, Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, Scotland, UKDepartment of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah 27272, United Arab EmiratesWe have previously found that sera from <i>Crocodylus porosus</i> contain anticancer agents and the treatment of MCF7 cells with this serum resulted in the differential expression of 51 genes. The purpose of this study was to use in silico analysis to identify genes that might be epigenetically modulated in cells treated with crocodile serum and to understand the role of potential genes as novel candidates with epigenetic therapeutic potential. The findings report five proto-oncogenes (<i>TUBA1B</i>, <i>SLC2A1</i>, <i>PGK1</i>, <i>CCND1</i>, and <i>NCAPD2</i>) and two tumor suppressor genes (<i>RPLP2</i>, <i>RPL37</i>) as novel therapeutic targets. Furthermore, we present a comprehensive overview of relevant studies on epigenetic regulation of these genes along with an insight into their clinical implications. Therefore, elucidating the molecules present in the serum and gut bacteria of reptiles such as crocodiles may offer insights into the role of these genes on longevity, health, disease, and life expectancy.https://www.mdpi.com/2306-7381/9/5/210epigeneticsDNA methylation<i>Crocodylus porosus</i>novel therapeutics |
| spellingShingle | Ruqaiyyah Siddiqui Jibran Sualeh Muhammad Sutherland K. Maciver Naveed Ahmed Khan <i>Crocodylus porosus</i> Sera a Potential Source to Identify Novel Epigenetic Targets: In Silico Analysis Veterinary Sciences epigenetics DNA methylation <i>Crocodylus porosus</i> novel therapeutics |
| title | <i>Crocodylus porosus</i> Sera a Potential Source to Identify Novel Epigenetic Targets: In Silico Analysis |
| title_full | <i>Crocodylus porosus</i> Sera a Potential Source to Identify Novel Epigenetic Targets: In Silico Analysis |
| title_fullStr | <i>Crocodylus porosus</i> Sera a Potential Source to Identify Novel Epigenetic Targets: In Silico Analysis |
| title_full_unstemmed | <i>Crocodylus porosus</i> Sera a Potential Source to Identify Novel Epigenetic Targets: In Silico Analysis |
| title_short | <i>Crocodylus porosus</i> Sera a Potential Source to Identify Novel Epigenetic Targets: In Silico Analysis |
| title_sort | i crocodylus porosus i sera a potential source to identify novel epigenetic targets in silico analysis |
| topic | epigenetics DNA methylation <i>Crocodylus porosus</i> novel therapeutics |
| url | https://www.mdpi.com/2306-7381/9/5/210 |
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