U-shaped association between plasma sphingosine-1-phosphate levels and mortality in patients with chronic systolic heart failure: a prospective cohort study
Abstract Background The endogenous lipid molecule sphingosine-1-phosphate (S1P) has received attention in the cardiovascular field due to its significant cardioprotective effects, as revealed in animal studies. The purpose of our study was to identify the distribution characteristics of S1P in systo...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-020-01262-2 |
| _version_ | 1818517062345031680 |
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| author | Yanbo Xue Wei Jiang Qiong Ma Xiqiang Wang Pu Jia Qiang Li Shuping Chen Bingxue Song Ya Wang Jingwen Zhang Jing Liu Guodong Yang Yuyao Lin Jing Liu Linyan Wei Caijuan Dong Haiquan Li Zhonglei Xie Ling Bai Aiqun Ma |
| author_facet | Yanbo Xue Wei Jiang Qiong Ma Xiqiang Wang Pu Jia Qiang Li Shuping Chen Bingxue Song Ya Wang Jingwen Zhang Jing Liu Guodong Yang Yuyao Lin Jing Liu Linyan Wei Caijuan Dong Haiquan Li Zhonglei Xie Ling Bai Aiqun Ma |
| author_sort | Yanbo Xue |
| collection | DOAJ |
| description | Abstract Background The endogenous lipid molecule sphingosine-1-phosphate (S1P) has received attention in the cardiovascular field due to its significant cardioprotective effects, as revealed in animal studies. The purpose of our study was to identify the distribution characteristics of S1P in systolic heart failure patients and the prognostic value of S1P for long-term prognosis. Methods We recruited 210 chronic systolic heart failure patients from June 2014 to December 2015. Meanwhile 54 healthy people in the same area were selected as controls. Plasma S1P was measured by liquid chromatography-tandem mass spectrometry. Patients were grouped according to the baseline S1P level quartiles, and restricted cubic spline plots described the association between S1P and all-cause death. Cox proportional hazard analysis was used to determine the relationship between category of S1P and all-cause death. Results Compared with the control group, the plasma S1P in chronic heart failure patients demonstrated a higher mean level (1.269 μmol/L vs 1.122 μmol/L, P = 0.006) and a larger standard deviation (0.441 vs 0.316, P = 0.022). Based on multivariable Cox regression with restricted cubic spline analysis, a non-linear and U-shaped association between S1P levels and the risk of all-cause death was observed. After a follow-up period of 31.7 ± 10.3 months, the second quartile (0.967–1.192 μml/L) with largely normal S1P levels had the lowest all-cause mortality and either an increase (adjusted HR = 2.368, 95%CI 1.006–5.572, P = 0.048) or a decrease (adjusted HR = 0.041, 95%CI 0.002–0.808, P = 0.036) predicted a worse prognosis. The survival curves showed that patients in the lowest quartile and highest quartile were at a higher risk of death. Conclusions Plasma S1P levels in systolic heart failure patients are related to the long-term all-cause mortality with a U-shaped correlation. Trial registration CHiCTR, ChiCTR-ONC-14004463 . Registered 20 March 2014. |
| first_indexed | 2024-12-11T00:51:07Z |
| format | Article |
| id | doaj.art-519767a93d3446e9a0a208a33b889a7f |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-11T00:51:07Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-519767a93d3446e9a0a208a33b889a7f2022-12-22T01:26:37ZengBMCLipids in Health and Disease1476-511X2020-06-0119111110.1186/s12944-020-01262-2U-shaped association between plasma sphingosine-1-phosphate levels and mortality in patients with chronic systolic heart failure: a prospective cohort studyYanbo Xue0Wei Jiang1Qiong Ma2Xiqiang Wang3Pu Jia4Qiang Li5Shuping Chen6Bingxue Song7Ya Wang8Jingwen Zhang9Jing Liu10Guodong Yang11Yuyao Lin12Jing Liu13Linyan Wei14Caijuan Dong15Haiquan Li16Zhonglei Xie17Ling Bai18Aiqun Ma19Department of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Pharmacy, the Second Affiliated Hospital of Air Force Medical UniversityDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationKey Laboratory of Resource Biology and Biotechnology in Western China, College of Life Sciences, Northwest UniversityDepartment of Epidemiology and Biostatistic, School of Public Health Xi’an Jiaotong University Health Science CenterDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationThe Affiliated Hospital of Qingdao UniversityDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Cardiology, the First Affiliated Hospital, Sun Yat-Sen UniversityDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationDepartment of Cardiovascular Medicine, First Affiliated Hospital of Xi’an Jiaotong University; Shaanxi Key Laboratory of Molecular Cardiology; Key Laboratory of Environment and Genes Related to Diseases, Ministry of EducationAbstract Background The endogenous lipid molecule sphingosine-1-phosphate (S1P) has received attention in the cardiovascular field due to its significant cardioprotective effects, as revealed in animal studies. The purpose of our study was to identify the distribution characteristics of S1P in systolic heart failure patients and the prognostic value of S1P for long-term prognosis. Methods We recruited 210 chronic systolic heart failure patients from June 2014 to December 2015. Meanwhile 54 healthy people in the same area were selected as controls. Plasma S1P was measured by liquid chromatography-tandem mass spectrometry. Patients were grouped according to the baseline S1P level quartiles, and restricted cubic spline plots described the association between S1P and all-cause death. Cox proportional hazard analysis was used to determine the relationship between category of S1P and all-cause death. Results Compared with the control group, the plasma S1P in chronic heart failure patients demonstrated a higher mean level (1.269 μmol/L vs 1.122 μmol/L, P = 0.006) and a larger standard deviation (0.441 vs 0.316, P = 0.022). Based on multivariable Cox regression with restricted cubic spline analysis, a non-linear and U-shaped association between S1P levels and the risk of all-cause death was observed. After a follow-up period of 31.7 ± 10.3 months, the second quartile (0.967–1.192 μml/L) with largely normal S1P levels had the lowest all-cause mortality and either an increase (adjusted HR = 2.368, 95%CI 1.006–5.572, P = 0.048) or a decrease (adjusted HR = 0.041, 95%CI 0.002–0.808, P = 0.036) predicted a worse prognosis. The survival curves showed that patients in the lowest quartile and highest quartile were at a higher risk of death. Conclusions Plasma S1P levels in systolic heart failure patients are related to the long-term all-cause mortality with a U-shaped correlation. Trial registration CHiCTR, ChiCTR-ONC-14004463 . Registered 20 March 2014.http://link.springer.com/article/10.1186/s12944-020-01262-2Heart failureSphingosine-1-phosphateAll-cause mortalityPrognosis |
| spellingShingle | Yanbo Xue Wei Jiang Qiong Ma Xiqiang Wang Pu Jia Qiang Li Shuping Chen Bingxue Song Ya Wang Jingwen Zhang Jing Liu Guodong Yang Yuyao Lin Jing Liu Linyan Wei Caijuan Dong Haiquan Li Zhonglei Xie Ling Bai Aiqun Ma U-shaped association between plasma sphingosine-1-phosphate levels and mortality in patients with chronic systolic heart failure: a prospective cohort study Lipids in Health and Disease Heart failure Sphingosine-1-phosphate All-cause mortality Prognosis |
| title | U-shaped association between plasma sphingosine-1-phosphate levels and mortality in patients with chronic systolic heart failure: a prospective cohort study |
| title_full | U-shaped association between plasma sphingosine-1-phosphate levels and mortality in patients with chronic systolic heart failure: a prospective cohort study |
| title_fullStr | U-shaped association between plasma sphingosine-1-phosphate levels and mortality in patients with chronic systolic heart failure: a prospective cohort study |
| title_full_unstemmed | U-shaped association between plasma sphingosine-1-phosphate levels and mortality in patients with chronic systolic heart failure: a prospective cohort study |
| title_short | U-shaped association between plasma sphingosine-1-phosphate levels and mortality in patients with chronic systolic heart failure: a prospective cohort study |
| title_sort | u shaped association between plasma sphingosine 1 phosphate levels and mortality in patients with chronic systolic heart failure a prospective cohort study |
| topic | Heart failure Sphingosine-1-phosphate All-cause mortality Prognosis |
| url | http://link.springer.com/article/10.1186/s12944-020-01262-2 |
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