Pseudoexfoliation Syndrome and Antidepressant Drug Use
Objectives:To investigate the relationship between pseudoexfoliation syndrome (PES) and the use of antidepressant medications.Materials and Methods:This population-based, cross-sectional study included 2,017 of 2,356 invited subjects who were randomly selected from the Turkish Statistical Institute...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2019-02-01
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| Series: | Türk Oftalmoloji Dergisi |
| Subjects: | |
| Online Access: |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/pseudoexfoliation-syndrome-and-antidepressant-drug/25475
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| _version_ | 1797916496487251968 |
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| author | Erdoğan Yaşar Nilgün Yıldırım Eray Atalay |
| author_facet | Erdoğan Yaşar Nilgün Yıldırım Eray Atalay |
| author_sort | Erdoğan Yaşar |
| collection | DOAJ |
| description | Objectives:To investigate the relationship between pseudoexfoliation syndrome (PES) and the use of antidepressant medications.Materials and Methods:This population-based, cross-sectional study included 2,017 of 2,356 invited subjects who were randomly selected from the Turkish Statistical Institute database (www.turksat.gov.tr/) as part of an epidemiologic study which specifically aimed to detect the prevalence of PES in the province of Eskişehir. During the examination, a detailed questionnaire was administered to determine physician-diagnosed systemic disease and drug use.Results:Eight of the 2,017 participants in the study were excluded for various reasons (2 with posterior synechiae, 2 with corneal opacity, 1 uncooperative patient, 1 eviscerated patient, 1 with active adenoviral keratoconjunctivitis, and 1 with a history of angle closure). PES was detected in 100 (5%) of the 2,009 patients whose data were analyzed. The percentage of subjects with concurrent antidepressant drug use in the PES and non-PES non-glaucoma groups were 4.1% (n=3) and 1.1% (n=21), respectively. The difference between the two groups was statistically significant (p=0.024). In addition, the use of medications for hypertension (p<0.001) and coronary artery disease (p=0.009) was also higher in the PES group.Conclusion:The higher prevalence of antidepressant drug use in patients with PES may be related to the processes of vascular damage and inflammation common to the pathogenesis of both PES and depression, as well as the high rate of chronic systemic comorbidities in these patients. |
| first_indexed | 2024-04-10T12:58:04Z |
| format | Article |
| id | doaj.art-519b2011a64a4117bb706a9987d73c54 |
| institution | Directory Open Access Journal |
| issn | 1300-0659 2147-2661 |
| language | English |
| last_indexed | 2024-04-10T12:58:04Z |
| publishDate | 2019-02-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Oftalmoloji Dergisi |
| spelling | doaj.art-519b2011a64a4117bb706a9987d73c542023-02-15T16:13:19ZengGalenos YayineviTürk Oftalmoloji Dergisi1300-06592147-26612019-02-014911510.4274/tjo.galenos.2018.0688713049054Pseudoexfoliation Syndrome and Antidepressant Drug UseErdoğan Yaşar0Nilgün Yıldırım1Eray Atalay2 Aksaray Üniversitesi Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, Aksaray, Türkiye Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Eskişehir, Türkiye Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Eskişehir, Türkiye Objectives:To investigate the relationship between pseudoexfoliation syndrome (PES) and the use of antidepressant medications.Materials and Methods:This population-based, cross-sectional study included 2,017 of 2,356 invited subjects who were randomly selected from the Turkish Statistical Institute database (www.turksat.gov.tr/) as part of an epidemiologic study which specifically aimed to detect the prevalence of PES in the province of Eskişehir. During the examination, a detailed questionnaire was administered to determine physician-diagnosed systemic disease and drug use.Results:Eight of the 2,017 participants in the study were excluded for various reasons (2 with posterior synechiae, 2 with corneal opacity, 1 uncooperative patient, 1 eviscerated patient, 1 with active adenoviral keratoconjunctivitis, and 1 with a history of angle closure). PES was detected in 100 (5%) of the 2,009 patients whose data were analyzed. The percentage of subjects with concurrent antidepressant drug use in the PES and non-PES non-glaucoma groups were 4.1% (n=3) and 1.1% (n=21), respectively. The difference between the two groups was statistically significant (p=0.024). In addition, the use of medications for hypertension (p<0.001) and coronary artery disease (p=0.009) was also higher in the PES group.Conclusion:The higher prevalence of antidepressant drug use in patients with PES may be related to the processes of vascular damage and inflammation common to the pathogenesis of both PES and depression, as well as the high rate of chronic systemic comorbidities in these patients. http://www.oftalmoloji.org/archives/archive-detail/article-preview/pseudoexfoliation-syndrome-and-antidepressant-drug/25475 Pseudoexfoliationdepressionantidepressant drug |
| spellingShingle | Erdoğan Yaşar Nilgün Yıldırım Eray Atalay Pseudoexfoliation Syndrome and Antidepressant Drug Use Türk Oftalmoloji Dergisi Pseudoexfoliation depression antidepressant drug |
| title | Pseudoexfoliation Syndrome and Antidepressant Drug Use |
| title_full | Pseudoexfoliation Syndrome and Antidepressant Drug Use |
| title_fullStr | Pseudoexfoliation Syndrome and Antidepressant Drug Use |
| title_full_unstemmed | Pseudoexfoliation Syndrome and Antidepressant Drug Use |
| title_short | Pseudoexfoliation Syndrome and Antidepressant Drug Use |
| title_sort | pseudoexfoliation syndrome and antidepressant drug use |
| topic | Pseudoexfoliation depression antidepressant drug |
| url |
http://www.oftalmoloji.org/archives/archive-detail/article-preview/pseudoexfoliation-syndrome-and-antidepressant-drug/25475
|
| work_keys_str_mv | AT erdoganyasar pseudoexfoliationsyndromeandantidepressantdruguse AT nilgunyıldırım pseudoexfoliationsyndromeandantidepressantdruguse AT erayatalay pseudoexfoliationsyndromeandantidepressantdruguse |