A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral Interventions
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of CoV disease 2019 (COVID-19) is a highly pathogenic and transmissible CoV that is presently plaguing the global human population and economy. No proven effective antiviral therapy or vaccine currently exists, and sup...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/6/426 |
| _version_ | 1827715918241726464 |
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| author | Sabari Nath Neerukonda Upendra Katneni |
| author_facet | Sabari Nath Neerukonda Upendra Katneni |
| author_sort | Sabari Nath Neerukonda |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of CoV disease 2019 (COVID-19) is a highly pathogenic and transmissible CoV that is presently plaguing the global human population and economy. No proven effective antiviral therapy or vaccine currently exists, and supportive care remains to be the cornerstone treatment. Through previous lessons learned from SARS-CoV-1 and MERS-CoV studies, scientific groups worldwide have rapidly expanded the knowledge pertaining to SARS-CoV-2 virology that includes in vitro and in vivo models for testing of antiviral therapies and randomized clinical trials. In the present narrative, we review SARS-CoV-2 virology, clinical features, pathophysiology, and animal models with a specific focus on the antiviral and adjunctive therapies currently being tested or that require testing in animal models and randomized clinical trials. |
| first_indexed | 2024-03-10T19:30:32Z |
| format | Article |
| id | doaj.art-519b83973c464037997501fbad3283cc |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T19:30:32Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-519b83973c464037997501fbad3283cc2023-11-20T02:11:01ZengMDPI AGPathogens2076-08172020-05-019642610.3390/pathogens9060426A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral InterventionsSabari Nath Neerukonda0Upendra Katneni1Department of Animal and Food Sciences, University of Delaware, Newark, DE 19716, USADepartment of Animal and Food Sciences, University of Delaware, Newark, DE 19716, USASevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of CoV disease 2019 (COVID-19) is a highly pathogenic and transmissible CoV that is presently plaguing the global human population and economy. No proven effective antiviral therapy or vaccine currently exists, and supportive care remains to be the cornerstone treatment. Through previous lessons learned from SARS-CoV-1 and MERS-CoV studies, scientific groups worldwide have rapidly expanded the knowledge pertaining to SARS-CoV-2 virology that includes in vitro and in vivo models for testing of antiviral therapies and randomized clinical trials. In the present narrative, we review SARS-CoV-2 virology, clinical features, pathophysiology, and animal models with a specific focus on the antiviral and adjunctive therapies currently being tested or that require testing in animal models and randomized clinical trials.https://www.mdpi.com/2076-0817/9/6/426SARS-CoV-2COVID-19animal modelsantivirals |
| spellingShingle | Sabari Nath Neerukonda Upendra Katneni A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral Interventions Pathogens SARS-CoV-2 COVID-19 animal models antivirals |
| title | A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral Interventions |
| title_full | A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral Interventions |
| title_fullStr | A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral Interventions |
| title_full_unstemmed | A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral Interventions |
| title_short | A Review on SARS-CoV-2 Virology, Pathophysiology, Animal Models, and Anti-Viral Interventions |
| title_sort | review on sars cov 2 virology pathophysiology animal models and anti viral interventions |
| topic | SARS-CoV-2 COVID-19 animal models antivirals |
| url | https://www.mdpi.com/2076-0817/9/6/426 |
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