Cellular senescence in brain aging and cognitive decline
Cellular senescence is a biological aging hallmark that plays a key role in the development of neurodegenerative diseases. Clinical trials are currently underway to evaluate the effectiveness of senotherapies for these diseases. However, the impact of senescence on brain aging and cognitive decline...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1281581/full |
| _version_ | 1797498182745194496 |
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| author | Areez Shafqat Saifullah Khan Mohamed H. Omer Mahnoor Niaz Ibrahem Albalkhi Khaled AlKattan Ahmed Yaqinuddin Tamara Tchkonia James L. Kirkland Shahrukh K. Hashmi Shahrukh K. Hashmi Shahrukh K. Hashmi |
| author_facet | Areez Shafqat Saifullah Khan Mohamed H. Omer Mahnoor Niaz Ibrahem Albalkhi Khaled AlKattan Ahmed Yaqinuddin Tamara Tchkonia James L. Kirkland Shahrukh K. Hashmi Shahrukh K. Hashmi Shahrukh K. Hashmi |
| author_sort | Areez Shafqat |
| collection | DOAJ |
| description | Cellular senescence is a biological aging hallmark that plays a key role in the development of neurodegenerative diseases. Clinical trials are currently underway to evaluate the effectiveness of senotherapies for these diseases. However, the impact of senescence on brain aging and cognitive decline in the absence of neurodegeneration remains uncertain. Moreover, patient populations like cancer survivors, traumatic brain injury survivors, obese individuals, obstructive sleep apnea patients, and chronic kidney disease patients can suffer age-related brain changes like cognitive decline prematurely, suggesting that they may suffer accelerated senescence in the brain. Understanding the role of senescence in neurocognitive deficits linked to these conditions is crucial, especially considering the rapidly evolving field of senotherapeutics. Such treatments could help alleviate early brain aging in these patients, significantly reducing patient morbidity and healthcare costs. This review provides a translational perspective on how cellular senescence plays a role in brain aging and age-related cognitive decline. We also discuss important caveats surrounding mainstream senotherapies like senolytics and senomorphics, and present emerging evidence of hyperbaric oxygen therapy and immune-directed therapies as viable modalities for reducing senescent cell burden. |
| first_indexed | 2024-03-10T03:29:48Z |
| format | Article |
| id | doaj.art-519caf32eebf4c0c9b2adc814246fd4e |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-10T03:29:48Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-519caf32eebf4c0c9b2adc814246fd4e2023-11-23T11:58:36ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-11-011510.3389/fnagi.2023.12815811281581Cellular senescence in brain aging and cognitive declineAreez Shafqat0Saifullah Khan1Mohamed H. Omer2Mahnoor Niaz3Ibrahem Albalkhi4Khaled AlKattan5Ahmed Yaqinuddin6Tamara Tchkonia7James L. Kirkland8Shahrukh K. Hashmi9Shahrukh K. Hashmi10Shahrukh K. Hashmi11College of Medicine, Alfaisal University, Riyadh, Saudi ArabiaMedical College, Aga Khan University, Karachi, PakistanSchool of Medicine, Cardiff University, Cardiff, United KingdomMedical College, Aga Khan University, Karachi, PakistanCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh, Saudi ArabiaRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United StatesRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, United StatesDepartment of Internal Medicine, Mayo Clinic, Rochester, MN, United StatesClinical Affairs, Khalifa University, Abu Dhabi, United Arab EmiratesDepartment of Medicine, SSMC, Abu Dhabi, United Arab EmiratesCellular senescence is a biological aging hallmark that plays a key role in the development of neurodegenerative diseases. Clinical trials are currently underway to evaluate the effectiveness of senotherapies for these diseases. However, the impact of senescence on brain aging and cognitive decline in the absence of neurodegeneration remains uncertain. Moreover, patient populations like cancer survivors, traumatic brain injury survivors, obese individuals, obstructive sleep apnea patients, and chronic kidney disease patients can suffer age-related brain changes like cognitive decline prematurely, suggesting that they may suffer accelerated senescence in the brain. Understanding the role of senescence in neurocognitive deficits linked to these conditions is crucial, especially considering the rapidly evolving field of senotherapeutics. Such treatments could help alleviate early brain aging in these patients, significantly reducing patient morbidity and healthcare costs. This review provides a translational perspective on how cellular senescence plays a role in brain aging and age-related cognitive decline. We also discuss important caveats surrounding mainstream senotherapies like senolytics and senomorphics, and present emerging evidence of hyperbaric oxygen therapy and immune-directed therapies as viable modalities for reducing senescent cell burden.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1281581/fullcellular senescenceagingcognitive declinetherapy-induced senescence (TIS)obesitytraumatic brain injury |
| spellingShingle | Areez Shafqat Saifullah Khan Mohamed H. Omer Mahnoor Niaz Ibrahem Albalkhi Khaled AlKattan Ahmed Yaqinuddin Tamara Tchkonia James L. Kirkland Shahrukh K. Hashmi Shahrukh K. Hashmi Shahrukh K. Hashmi Cellular senescence in brain aging and cognitive decline Frontiers in Aging Neuroscience cellular senescence aging cognitive decline therapy-induced senescence (TIS) obesity traumatic brain injury |
| title | Cellular senescence in brain aging and cognitive decline |
| title_full | Cellular senescence in brain aging and cognitive decline |
| title_fullStr | Cellular senescence in brain aging and cognitive decline |
| title_full_unstemmed | Cellular senescence in brain aging and cognitive decline |
| title_short | Cellular senescence in brain aging and cognitive decline |
| title_sort | cellular senescence in brain aging and cognitive decline |
| topic | cellular senescence aging cognitive decline therapy-induced senescence (TIS) obesity traumatic brain injury |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1281581/full |
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