The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs
Background. Candida spp. has been identified as the most common member of human gut microbiota. This yeast-like fungus is recognized as an opportunistic organism due to its potential to cause diseases in all parts of the gastrointestinal tract. Objective. The aim of the study was to investigate the...
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| Format: | Article |
| Language: | English |
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National Institute of Public Health - National Institute of Hygiene
2019-06-01
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| Series: | Roczniki Panstwowego Zakladu Higieny |
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| Online Access: | http://wydawnictwa.pzh.gov.pl/roczniki_pzh/pobierz-artykul?id=1287 |
| _version_ | 1818107504634101760 |
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| author | Małgorzata Jeziorek Magdalena Frej-Mądrzak Irena Choroszy-Król |
| author_facet | Małgorzata Jeziorek Magdalena Frej-Mądrzak Irena Choroszy-Król |
| author_sort | Małgorzata Jeziorek |
| collection | DOAJ |
| description | Background. Candida spp. has been identified as the most common member of human gut microbiota. This yeast-like fungus is recognized as an opportunistic organism due to its potential to cause diseases in all parts of the gastrointestinal tract.
Objective. The aim of the study was to investigate the relationship between diet and health of the study participants and the presence of gastrointestinal Candida spp. Susceptibility of Candida to antifungal drugs was determined.
Material and methods. Material comprised of oral swabs and fecal samples self-collected by the study participants. The participants filled in a nutritional questionnaire. A total of 30 people took part in the study, including 28 women and 2 men. The study was conducted in Wroclaw, Poland. Susceptibility of Candida to antifungal drugs was determined using Bio-Rad’s FUNGITEST™ Kit designed for the susceptibility testing of yeasts to six antifungal drugs.
Results. In the group with negative Candida spp. cultures, healthier wheat flour substitutes were consumed significantly more frequently than in the group with positive Candida spp. cultures. Yellow cheeses and quark were eaten significantly more frequently in the group with negative Candida spp. cultures. No antifungal resistance was detected in the study group.
Conclusions. The increased consumption of purified wheat flour products was linked to the presence of gastrointestinal Candida spp. A higher consumption of cheese was observed in the group with negative Candida spp. cultures, which may indicate the inhibitory effect of saturated fatty acids on the growth of human Candida spp. Sensitivity of C. albicans to antifungal drugs may increase effectiveness of candidiasis treatment. |
| first_indexed | 2024-12-11T02:00:31Z |
| format | Article |
| id | doaj.art-519d44b9e7844d46b8fb3388e2ce99d1 |
| institution | Directory Open Access Journal |
| issn | 0035-7715 2451-2311 |
| language | English |
| last_indexed | 2024-12-11T02:00:31Z |
| publishDate | 2019-06-01 |
| publisher | National Institute of Public Health - National Institute of Hygiene |
| record_format | Article |
| series | Roczniki Panstwowego Zakladu Higieny |
| spelling | doaj.art-519d44b9e7844d46b8fb3388e2ce99d12022-12-22T01:24:30ZengNational Institute of Public Health - National Institute of HygieneRoczniki Panstwowego Zakladu Higieny0035-77152451-23112019-06-0170219520010.32394/rpzh.2019.0070The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugsMałgorzata Jeziorek0Magdalena Frej-Mądrzak1Irena Choroszy-Król2Department of Dietetics, Faculty of Health Sciences, Wroclaw Medical University, PolandDepartment of Basic Sciences, Faculty of Health Sciences, Wroclaw Medical University, PolandDepartment of Basic Sciences, Faculty of Health Sciences, Wroclaw Medical University, PolandBackground. Candida spp. has been identified as the most common member of human gut microbiota. This yeast-like fungus is recognized as an opportunistic organism due to its potential to cause diseases in all parts of the gastrointestinal tract. Objective. The aim of the study was to investigate the relationship between diet and health of the study participants and the presence of gastrointestinal Candida spp. Susceptibility of Candida to antifungal drugs was determined. Material and methods. Material comprised of oral swabs and fecal samples self-collected by the study participants. The participants filled in a nutritional questionnaire. A total of 30 people took part in the study, including 28 women and 2 men. The study was conducted in Wroclaw, Poland. Susceptibility of Candida to antifungal drugs was determined using Bio-Rad’s FUNGITEST™ Kit designed for the susceptibility testing of yeasts to six antifungal drugs. Results. In the group with negative Candida spp. cultures, healthier wheat flour substitutes were consumed significantly more frequently than in the group with positive Candida spp. cultures. Yellow cheeses and quark were eaten significantly more frequently in the group with negative Candida spp. cultures. No antifungal resistance was detected in the study group. Conclusions. The increased consumption of purified wheat flour products was linked to the presence of gastrointestinal Candida spp. A higher consumption of cheese was observed in the group with negative Candida spp. cultures, which may indicate the inhibitory effect of saturated fatty acids on the growth of human Candida spp. Sensitivity of C. albicans to antifungal drugs may increase effectiveness of candidiasis treatment.http://wydawnictwa.pzh.gov.pl/roczniki_pzh/pobierz-artykul?id=1287Candida spp.dietfecal samplesantibioticsdrug resistance |
| spellingShingle | Małgorzata Jeziorek Magdalena Frej-Mądrzak Irena Choroszy-Król The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs Roczniki Panstwowego Zakladu Higieny Candida spp. diet fecal samples antibiotics drug resistance |
| title | The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs |
| title_full | The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs |
| title_fullStr | The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs |
| title_full_unstemmed | The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs |
| title_short | The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs |
| title_sort | influence of diet on gastrointestinal candida spp colonization and the susceptibility of candida spp to antifungal drugs |
| topic | Candida spp. diet fecal samples antibiotics drug resistance |
| url | http://wydawnictwa.pzh.gov.pl/roczniki_pzh/pobierz-artykul?id=1287 |
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