Altered Cerebrospinal Fluid Clearance and Increased Intracranial Pressure in Rats 18 h After Experimental Cortical Ischaemia

Altered Cerebrospinal Fluid Clearance and Increased Intracranial Pressure in Rats 18 h After Experimental Cortical Ischaemia

Oedema-independent intracranial pressure (ICP) rise peaks 20–22-h post-stroke in rats and may explain early neurological deterioration. Cerebrospinal fluid (CSF) volume changes may be involved. Cranial CSF clearance primarily occurs via the cervical lymphatics and movement into the spinal portion of...

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Bibliographic Details
Main Authors: Steven W. Bothwell, Daniel Omileke, Rebecca J. Hood, Debbie-Gai Pepperall, Sara Azarpeykan, Adjanie Patabendige, Neil J. Spratt
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cerebrospinal fluid
infarct expansion
neurological deterioration
ischaemia
intracranial pressure
stroke
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.712779/full

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