Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence?
James Parkinson first described the motor symptoms of the disease that took his name over 200 years ago. While our knowledge of many of the changes that occur in this condition has increased, it is still unknown what causes this neurodegeneration and why it only affects some individuals with advanci...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/8/2/38 |
| _version_ | 1797728686240169984 |
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| author | Chun Chen Doug M. Turnbull Amy K. Reeve |
| author_facet | Chun Chen Doug M. Turnbull Amy K. Reeve |
| author_sort | Chun Chen |
| collection | DOAJ |
| description | James Parkinson first described the motor symptoms of the disease that took his name over 200 years ago. While our knowledge of many of the changes that occur in this condition has increased, it is still unknown what causes this neurodegeneration and why it only affects some individuals with advancing age. Here we review current literature to discuss whether the mitochondrial dysfunction we have detected in Parkinson’s disease is a pathogenic cause of neuronal loss or whether it is itself a consequence of dysfunction in other pathways. We examine research data from cases of idiopathic Parkinson’s with that from model systems and individuals with familial forms of the disease. Furthermore, we include data from healthy aged individuals to highlight that many of the changes described are also present with advancing age, though not normally in the presence of severe neurodegeneration. While a definitive answer to this question may still be just out of reach, it is clear that mitochondrial dysfunction sits prominently at the centre of the disease pathway that leads to catastrophic neuronal loss in those affected by this disease. |
| first_indexed | 2024-03-12T11:17:36Z |
| format | Article |
| id | doaj.art-519dec9e05e34f88a8f40f2b9fb8b390 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-12T11:17:36Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-519dec9e05e34f88a8f40f2b9fb8b3902023-09-02T01:43:57ZengMDPI AGBiology2079-77372019-05-01823810.3390/biology8020038biology8020038Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence?Chun Chen0Doug M. Turnbull1Amy K. Reeve2Wellcome Centre for Mitochondrial Research, Institute for Neuroscience, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UKWellcome Centre for Mitochondrial Research, Institute for Neuroscience, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UKWellcome Centre for Mitochondrial Research, Institute for Neuroscience, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, NE2 4HH, UKJames Parkinson first described the motor symptoms of the disease that took his name over 200 years ago. While our knowledge of many of the changes that occur in this condition has increased, it is still unknown what causes this neurodegeneration and why it only affects some individuals with advancing age. Here we review current literature to discuss whether the mitochondrial dysfunction we have detected in Parkinson’s disease is a pathogenic cause of neuronal loss or whether it is itself a consequence of dysfunction in other pathways. We examine research data from cases of idiopathic Parkinson’s with that from model systems and individuals with familial forms of the disease. Furthermore, we include data from healthy aged individuals to highlight that many of the changes described are also present with advancing age, though not normally in the presence of severe neurodegeneration. While a definitive answer to this question may still be just out of reach, it is clear that mitochondrial dysfunction sits prominently at the centre of the disease pathway that leads to catastrophic neuronal loss in those affected by this disease.https://www.mdpi.com/2079-7737/8/2/38Parkinson’s diseasemitochondriaageingneurodegenerative disease |
| spellingShingle | Chun Chen Doug M. Turnbull Amy K. Reeve Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence? Biology Parkinson’s disease mitochondria ageing neurodegenerative disease |
| title | Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence? |
| title_full | Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence? |
| title_fullStr | Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence? |
| title_full_unstemmed | Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence? |
| title_short | Mitochondrial Dysfunction in Parkinson’s Disease—Cause or Consequence? |
| title_sort | mitochondrial dysfunction in parkinson s disease cause or consequence |
| topic | Parkinson’s disease mitochondria ageing neurodegenerative disease |
| url | https://www.mdpi.com/2079-7737/8/2/38 |
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