Role of Probiotic Lactobacillus reuteri in Improving Gut Health and Immunity in Infants and Toddlers: A Review
The infant gut undergoes significant developmental phases that are fully dependent upon the colonization with microorganisms, beginning at birth. This colonization of gut microbiota has a powerful impact on host metabolic and immune homoeostasis. Probiotics strains exhibit a wide range of health ben...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2022-06-01
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| Series: | International Journal of Nutrition Sciences |
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| Online Access: | https://ijns.sums.ac.ir/article_48501_d36dcbb7634eb73d19cd278fef565773.pdf |
| _version_ | 1818018769730011136 |
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| author | MD. Jahangir Alam Mirza MD. Islam MD. Abu Tayab Hossain Sahid Kamrul Alam MD. Kamruzzzaman Kamrul Salauddin Mahmood ATM Azharul Haque |
| author_facet | MD. Jahangir Alam Mirza MD. Islam MD. Abu Tayab Hossain Sahid Kamrul Alam MD. Kamruzzzaman Kamrul Salauddin Mahmood ATM Azharul Haque |
| author_sort | MD. Jahangir Alam |
| collection | DOAJ |
| description | The infant gut undergoes significant developmental phases that are fully dependent upon the colonization with microorganisms, beginning at birth. This colonization of gut microbiota has a powerful impact on host metabolic and immune homoeostasis. Probiotics strains exhibit a wide range of health benefits by modifying the intestinal microbiota and immunity. Lactobacillus reuteri is one of the most extensively studied probiotic strains. It promotes gut health by stimulation of mucosal gut barrier functions, production of antimicrobial substances (such as reuterin and lactic acid) and influencing acquired and innate immune responses. Reuterin produced by L. reuteri is a potent anti-microbial compoundcapable of inhibiting a wide spectrum of pathogenic microorganisms. Apart from antimicrobial metabolite production, L. reuteri creates biofilms that stimulate tumor necrosis factor production by lipopolysaccharide (LPS)- activated monocytoid cells. Interestingly, L. reuteri administration has emerged as a potential therapy for childhood functional gastrointestinal disturbances as these disturbances are associated with gut microbiota perturbations in early life. The current review summarizes the beneficial aspects of the probiotic L. reuteri strain in clinical practice with a special focus on its role in improving gut health and immunity in infants and toddlers. |
| first_indexed | 2024-04-14T07:44:09Z |
| format | Article |
| id | doaj.art-519ef23f51b5458abe05c2db825b7005 |
| institution | Directory Open Access Journal |
| issn | 2538-1873 2538-2829 |
| language | English |
| last_indexed | 2024-04-14T07:44:09Z |
| publishDate | 2022-06-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | International Journal of Nutrition Sciences |
| spelling | doaj.art-519ef23f51b5458abe05c2db825b70052022-12-22T02:05:24ZengShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18732538-28292022-06-0172758010.30476/ijns.2022.94849.118248501Role of Probiotic Lactobacillus reuteri in Improving Gut Health and Immunity in Infants and Toddlers: A ReviewMD. Jahangir Alam0Mirza MD. Islam1MD. Abu Tayab2Hossain Sahid Kamrul Alam3MD. Kamruzzzaman Kamrul4Salauddin Mahmood5ATM Azharul Haque6Bangladesh Shishu Hospital and Institute, Sher-e-Bangla Nagar, Dhaka, BangladeshBangladesh Shishu Hospital and Institute, Sher-e-Bangla Nagar, Dhaka, BangladeshBangladesh Shishu Hospital and Institute, Sher-e-Bangla Nagar, Dhaka, BangladeshBangladesh Shishu Hospital and Institute, Sher-e-Bangla Nagar, Dhaka, BangladeshBangladesh Shishu Hospital and Institute, Sher-e-Bangla Nagar, Dhaka, BangladeshBangladesh Shishu Hospital and Institute, Sher-e-Bangla Nagar, Dhaka, BangladeshBangladesh Shishu Hospital and Institute, Sher-e-Bangla Nagar, Dhaka, BangladeshThe infant gut undergoes significant developmental phases that are fully dependent upon the colonization with microorganisms, beginning at birth. This colonization of gut microbiota has a powerful impact on host metabolic and immune homoeostasis. Probiotics strains exhibit a wide range of health benefits by modifying the intestinal microbiota and immunity. Lactobacillus reuteri is one of the most extensively studied probiotic strains. It promotes gut health by stimulation of mucosal gut barrier functions, production of antimicrobial substances (such as reuterin and lactic acid) and influencing acquired and innate immune responses. Reuterin produced by L. reuteri is a potent anti-microbial compoundcapable of inhibiting a wide spectrum of pathogenic microorganisms. Apart from antimicrobial metabolite production, L. reuteri creates biofilms that stimulate tumor necrosis factor production by lipopolysaccharide (LPS)- activated monocytoid cells. Interestingly, L. reuteri administration has emerged as a potential therapy for childhood functional gastrointestinal disturbances as these disturbances are associated with gut microbiota perturbations in early life. The current review summarizes the beneficial aspects of the probiotic L. reuteri strain in clinical practice with a special focus on its role in improving gut health and immunity in infants and toddlers.https://ijns.sums.ac.ir/article_48501_d36dcbb7634eb73d19cd278fef565773.pdflactobacillus reuteriprobioticsgut healthimmunomodulationinfants |
| spellingShingle | MD. Jahangir Alam Mirza MD. Islam MD. Abu Tayab Hossain Sahid Kamrul Alam MD. Kamruzzzaman Kamrul Salauddin Mahmood ATM Azharul Haque Role of Probiotic Lactobacillus reuteri in Improving Gut Health and Immunity in Infants and Toddlers: A Review International Journal of Nutrition Sciences lactobacillus reuteri probiotics gut health immunomodulation infants |
| title | Role of Probiotic Lactobacillus reuteri in Improving Gut Health and Immunity in Infants and Toddlers: A Review |
| title_full | Role of Probiotic Lactobacillus reuteri in Improving Gut Health and Immunity in Infants and Toddlers: A Review |
| title_fullStr | Role of Probiotic Lactobacillus reuteri in Improving Gut Health and Immunity in Infants and Toddlers: A Review |
| title_full_unstemmed | Role of Probiotic Lactobacillus reuteri in Improving Gut Health and Immunity in Infants and Toddlers: A Review |
| title_short | Role of Probiotic Lactobacillus reuteri in Improving Gut Health and Immunity in Infants and Toddlers: A Review |
| title_sort | role of probiotic lactobacillus reuteri in improving gut health and immunity in infants and toddlers a review |
| topic | lactobacillus reuteri probiotics gut health immunomodulation infants |
| url | https://ijns.sums.ac.ir/article_48501_d36dcbb7634eb73d19cd278fef565773.pdf |
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