Recent advances in the understanding and management of bipolar disorder in adults [version 1; referees: 2 approved]
This article focuses on some aspects of recent progress in the neurobiology and treatment of bipolar disorder (BD) in adults. A molecular-genetic approach to the etiopathogenesis of the illness resulted in the findings of a genetic overlap between BD and other major psychiatric disorders. Furthermor...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-11-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/6-2033/v1 |
| _version_ | 1818242878787289088 |
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| author | Janusz K. Rybakowski |
| author_facet | Janusz K. Rybakowski |
| author_sort | Janusz K. Rybakowski |
| collection | DOAJ |
| description | This article focuses on some aspects of recent progress in the neurobiology and treatment of bipolar disorder (BD) in adults. A molecular-genetic approach to the etiopathogenesis of the illness resulted in the findings of a genetic overlap between BD and other major psychiatric disorders. Furthermore, a poly-gene-environmental interaction in the development of the illness has been demonstrated. For the management of BD, new drugs with putative mood-stabilizing properties have been introduced in the past two decades. However, none of these can surpass lithium, the prototype mood-stabilizer, still considered the most specific drug for BD. Recent research on lithium, besides providing new data on the neurobiology of BD, has confirmed anti-suicidal, immunomodulatory, and neuroprotective properties of this drug. |
| first_indexed | 2024-12-12T13:52:14Z |
| format | Article |
| id | doaj.art-51a057487f9e412eb4f00cf71f3c4424 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-12T13:52:14Z |
| publishDate | 2017-11-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-51a057487f9e412eb4f00cf71f3c44242022-12-22T00:22:32ZengF1000 Research LtdF1000Research2046-14022017-11-01610.12688/f1000research.12329.113347Recent advances in the understanding and management of bipolar disorder in adults [version 1; referees: 2 approved]Janusz K. Rybakowski0Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, PolandThis article focuses on some aspects of recent progress in the neurobiology and treatment of bipolar disorder (BD) in adults. A molecular-genetic approach to the etiopathogenesis of the illness resulted in the findings of a genetic overlap between BD and other major psychiatric disorders. Furthermore, a poly-gene-environmental interaction in the development of the illness has been demonstrated. For the management of BD, new drugs with putative mood-stabilizing properties have been introduced in the past two decades. However, none of these can surpass lithium, the prototype mood-stabilizer, still considered the most specific drug for BD. Recent research on lithium, besides providing new data on the neurobiology of BD, has confirmed anti-suicidal, immunomodulatory, and neuroprotective properties of this drug.https://f1000research.com/articles/6-2033/v1Behavioral NeuroscienceCognitive Neurology & DementiaDevelopmental & Pediatric NeurologyMood DisordersNeurobiology of Disease & RegenerationNeuropharmacology & PsychopharmacologyPersonality & Impulse DisordersSchizophrenia & Other Psychoses |
| spellingShingle | Janusz K. Rybakowski Recent advances in the understanding and management of bipolar disorder in adults [version 1; referees: 2 approved] F1000Research Behavioral Neuroscience Cognitive Neurology & Dementia Developmental & Pediatric Neurology Mood Disorders Neurobiology of Disease & Regeneration Neuropharmacology & Psychopharmacology Personality & Impulse Disorders Schizophrenia & Other Psychoses |
| title | Recent advances in the understanding and management of bipolar disorder in adults [version 1; referees: 2 approved] |
| title_full | Recent advances in the understanding and management of bipolar disorder in adults [version 1; referees: 2 approved] |
| title_fullStr | Recent advances in the understanding and management of bipolar disorder in adults [version 1; referees: 2 approved] |
| title_full_unstemmed | Recent advances in the understanding and management of bipolar disorder in adults [version 1; referees: 2 approved] |
| title_short | Recent advances in the understanding and management of bipolar disorder in adults [version 1; referees: 2 approved] |
| title_sort | recent advances in the understanding and management of bipolar disorder in adults version 1 referees 2 approved |
| topic | Behavioral Neuroscience Cognitive Neurology & Dementia Developmental & Pediatric Neurology Mood Disorders Neurobiology of Disease & Regeneration Neuropharmacology & Psychopharmacology Personality & Impulse Disorders Schizophrenia & Other Psychoses |
| url | https://f1000research.com/articles/6-2033/v1 |
| work_keys_str_mv | AT januszkrybakowski recentadvancesintheunderstandingandmanagementofbipolardisorderinadultsversion1referees2approved |