Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice.

Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice.

Liver fibrosis is characterized by excessive synthesis of extracellular matrix proteins, which prevails over their enzymatic degradation, primarily by matrix metalloproteinases (MMPs). The effect of pharmacological MMP inhibition on fibrogenesis, however, is largely unexplored. Inflammation is consi...

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Podrobná bibliografie
Hlavní autoři: Vincent E de Meijer, Deanna Y Sverdlov, Yury Popov, Hau D Le, Jonathan A Meisel, Vânia Nosé, Detlef Schuppan, Mark Puder
Médium: Článek
Jazyk:English
Vydáno: Public Library of Science (PLoS) 2010-06-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC2892485?pdf=render

Internet

http://europepmc.org/articles/PMC2892485?pdf=render

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