Reduced burden of Arsenic-Related cancers after water mitigation in Taiwan
Background: Epidemiological evidence has demonstrated an association between arsenic in drinking water and increased cancer incidence. This population-based study investigates the impact of a tap water supply system installation in Blackfoot disease-endemic regions of Taiwan on cancer incidence. Met...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Environment International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024001284 |
| _version_ | 1797248408813043712 |
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| author | Jing-Rong Jhuang Chih-Hung Lee Chun-Ju Chiang Chien-Jen Chen Wen-Chung Lee |
| author_facet | Jing-Rong Jhuang Chih-Hung Lee Chun-Ju Chiang Chien-Jen Chen Wen-Chung Lee |
| author_sort | Jing-Rong Jhuang |
| collection | DOAJ |
| description | Background: Epidemiological evidence has demonstrated an association between arsenic in drinking water and increased cancer incidence. This population-based study investigates the impact of a tap water supply system installation in Blackfoot disease-endemic regions of Taiwan on cancer incidence. Methods: By using the Taiwan Cancer Registry dataset, we enrolled patients aged 40–84 diagnosed with arsenic-related cancers, including hepatocellular carcinoma, small and squamous cell lung cancer, Bowen’s disease, basal and squamous cell skin cancer, urothelial bladder cancer, and upper tract urothelial carcinoma between 1995 and 2019. Random-effects age-period-cohort models were used to estimate the cancer incidence data, and a stabilized kriging method was employed to interpolate incidence rates to more precise spatiotemporal units. Results: The results showed that the age-standardized incidence rates of all six types of studied cancers were consistently higher in Blackfoot disease-endemic areas than those in other areas from 1995 to 2019. However, the gap in incidence rates between Blackfoot disease-endemic areas and the remaining regions began to narrow approximately after the 1960 birth cohort when the tap water supply system installation commenced. For small and squamous cell lung cancer, Bowen’s disease, and urothelial bladder cancer, the excess incidence rates sharply declined to null for those born after the year of arsenic mitigation. For upper tract urothelial carcinoma, the excess incidence rates decreased more gradually for those born after the year of arsenic mitigation. For hepatocellular carcinoma and basal and squamous cell skin cancer, the excess incidence rates remained constant. Spatiotemporal clusters of high incidence rates were identified in the core townships of Blackfoot disease-endemic areas. These clusters began to dissipate mainly after the 1960 birth cohort. Conclusion: Arsenic mitigation from drinking water in Taiwan is associated with a reduced burden of small and squamous cell lung cancers, Bowen’s disease, urothelial bladder cancer, and upper tract urothelial carcinoma. |
| first_indexed | 2024-04-24T20:14:07Z |
| format | Article |
| id | doaj.art-51a1dd74ed6944ce9c89d2b168ddbc85 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-24T20:14:07Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-51a1dd74ed6944ce9c89d2b168ddbc852024-03-23T06:22:17ZengElsevierEnvironment International0160-41202024-03-01185108542Reduced burden of Arsenic-Related cancers after water mitigation in TaiwanJing-Rong Jhuang0Chih-Hung Lee1Chun-Ju Chiang2Chien-Jen Chen3Wen-Chung Lee4Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Taiwan Cancer Registry, Taipei, TaiwanDepartment of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Taiwan Cancer Registry, Taipei, TaiwanGenomics Research Center, Academia Sinica, Taipei, Taiwan; College of Medicine, Fu-Jen Catholic University, New Taipei, TaiwanInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan; Taiwan Cancer Registry, Taipei, Taiwan; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Taipei, Taiwan; Corresponding author at: Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Rm. 536, No. 17, Xuzhou Rd., Taipei 100, Taiwan.Background: Epidemiological evidence has demonstrated an association between arsenic in drinking water and increased cancer incidence. This population-based study investigates the impact of a tap water supply system installation in Blackfoot disease-endemic regions of Taiwan on cancer incidence. Methods: By using the Taiwan Cancer Registry dataset, we enrolled patients aged 40–84 diagnosed with arsenic-related cancers, including hepatocellular carcinoma, small and squamous cell lung cancer, Bowen’s disease, basal and squamous cell skin cancer, urothelial bladder cancer, and upper tract urothelial carcinoma between 1995 and 2019. Random-effects age-period-cohort models were used to estimate the cancer incidence data, and a stabilized kriging method was employed to interpolate incidence rates to more precise spatiotemporal units. Results: The results showed that the age-standardized incidence rates of all six types of studied cancers were consistently higher in Blackfoot disease-endemic areas than those in other areas from 1995 to 2019. However, the gap in incidence rates between Blackfoot disease-endemic areas and the remaining regions began to narrow approximately after the 1960 birth cohort when the tap water supply system installation commenced. For small and squamous cell lung cancer, Bowen’s disease, and urothelial bladder cancer, the excess incidence rates sharply declined to null for those born after the year of arsenic mitigation. For upper tract urothelial carcinoma, the excess incidence rates decreased more gradually for those born after the year of arsenic mitigation. For hepatocellular carcinoma and basal and squamous cell skin cancer, the excess incidence rates remained constant. Spatiotemporal clusters of high incidence rates were identified in the core townships of Blackfoot disease-endemic areas. These clusters began to dissipate mainly after the 1960 birth cohort. Conclusion: Arsenic mitigation from drinking water in Taiwan is associated with a reduced burden of small and squamous cell lung cancers, Bowen’s disease, urothelial bladder cancer, and upper tract urothelial carcinoma.http://www.sciencedirect.com/science/article/pii/S0160412024001284Drinking waterArsenic mitigationCancer incidenceAge-period-cohort analysis |
| spellingShingle | Jing-Rong Jhuang Chih-Hung Lee Chun-Ju Chiang Chien-Jen Chen Wen-Chung Lee Reduced burden of Arsenic-Related cancers after water mitigation in Taiwan Environment International Drinking water Arsenic mitigation Cancer incidence Age-period-cohort analysis |
| title | Reduced burden of Arsenic-Related cancers after water mitigation in Taiwan |
| title_full | Reduced burden of Arsenic-Related cancers after water mitigation in Taiwan |
| title_fullStr | Reduced burden of Arsenic-Related cancers after water mitigation in Taiwan |
| title_full_unstemmed | Reduced burden of Arsenic-Related cancers after water mitigation in Taiwan |
| title_short | Reduced burden of Arsenic-Related cancers after water mitigation in Taiwan |
| title_sort | reduced burden of arsenic related cancers after water mitigation in taiwan |
| topic | Drinking water Arsenic mitigation Cancer incidence Age-period-cohort analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024001284 |
| work_keys_str_mv | AT jingrongjhuang reducedburdenofarsenicrelatedcancersafterwatermitigationintaiwan AT chihhunglee reducedburdenofarsenicrelatedcancersafterwatermitigationintaiwan AT chunjuchiang reducedburdenofarsenicrelatedcancersafterwatermitigationintaiwan AT chienjenchen reducedburdenofarsenicrelatedcancersafterwatermitigationintaiwan AT wenchunglee reducedburdenofarsenicrelatedcancersafterwatermitigationintaiwan |