Cellular Plasticity in Mammary Gland Development and Breast Cancer
Cellular plasticity is a phenomenon where cells adopt different identities during development and tissue homeostasis as a response to physiological and pathological conditions. This review provides a general introduction to processes by which cells change their identity as well as the current defini...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/23/5605 |
| _version_ | 1797400376861786112 |
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| author | Madison N. Wicker Kay-Uwe Wagner |
| author_facet | Madison N. Wicker Kay-Uwe Wagner |
| author_sort | Madison N. Wicker |
| collection | DOAJ |
| description | Cellular plasticity is a phenomenon where cells adopt different identities during development and tissue homeostasis as a response to physiological and pathological conditions. This review provides a general introduction to processes by which cells change their identity as well as the current definition of cellular plasticity in the field of mammary gland biology. Following a synopsis of the evolving model of the hierarchical development of mammary epithelial cell lineages, we discuss changes in cell identity during normal mammary gland development with particular emphasis on the effect of the gestation cycle on the emergence of new cellular states. Next, we summarize known mechanisms that promote the plasticity of epithelial lineages in the normal mammary gland and highlight the importance of the microenvironment and extracellular matrix. A discourse of cellular reprogramming during the early stages of mammary tumorigenesis that follows focuses on the origin of basal-like breast cancers from luminal progenitors and oncogenic signaling networks that orchestrate diverse developmental trajectories of transforming epithelial cells. In addition to the epithelial-to-mesenchymal transition, we highlight events of cellular reprogramming during breast cancer progression in the context of intrinsic molecular subtype switching and the genesis of the claudin-low breast cancer subtype, which represents the far end of the spectrum of epithelial cell plasticity. In the final section, we will discuss recent advances in the design of genetically engineered models to gain insight into the dynamic processes that promote cellular plasticity during mammary gland development and tumorigenesis in vivo. |
| first_indexed | 2024-03-09T01:53:44Z |
| format | Article |
| id | doaj.art-51a240307ab04358bb613d5e7eeebcfb |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T01:53:44Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-51a240307ab04358bb613d5e7eeebcfb2023-12-08T15:12:40ZengMDPI AGCancers2072-66942023-11-011523560510.3390/cancers15235605Cellular Plasticity in Mammary Gland Development and Breast CancerMadison N. Wicker0Kay-Uwe Wagner1Department of Oncology, Wayne State University School of Medicine and Tumor Biology Program, Barbara Ann Karmanos Cancer Institute, 4100 John R, EL01TM, Detroit, MI 48201, USADepartment of Oncology, Wayne State University School of Medicine and Tumor Biology Program, Barbara Ann Karmanos Cancer Institute, 4100 John R, EL01TM, Detroit, MI 48201, USACellular plasticity is a phenomenon where cells adopt different identities during development and tissue homeostasis as a response to physiological and pathological conditions. This review provides a general introduction to processes by which cells change their identity as well as the current definition of cellular plasticity in the field of mammary gland biology. Following a synopsis of the evolving model of the hierarchical development of mammary epithelial cell lineages, we discuss changes in cell identity during normal mammary gland development with particular emphasis on the effect of the gestation cycle on the emergence of new cellular states. Next, we summarize known mechanisms that promote the plasticity of epithelial lineages in the normal mammary gland and highlight the importance of the microenvironment and extracellular matrix. A discourse of cellular reprogramming during the early stages of mammary tumorigenesis that follows focuses on the origin of basal-like breast cancers from luminal progenitors and oncogenic signaling networks that orchestrate diverse developmental trajectories of transforming epithelial cells. In addition to the epithelial-to-mesenchymal transition, we highlight events of cellular reprogramming during breast cancer progression in the context of intrinsic molecular subtype switching and the genesis of the claudin-low breast cancer subtype, which represents the far end of the spectrum of epithelial cell plasticity. In the final section, we will discuss recent advances in the design of genetically engineered models to gain insight into the dynamic processes that promote cellular plasticity during mammary gland development and tumorigenesis in vivo.https://www.mdpi.com/2072-6694/15/23/5605cellular plasticityepithelial-to-mesenchymal transitionmammary gland developmenttumorigenesisbreast cancermouse models |
| spellingShingle | Madison N. Wicker Kay-Uwe Wagner Cellular Plasticity in Mammary Gland Development and Breast Cancer Cancers cellular plasticity epithelial-to-mesenchymal transition mammary gland development tumorigenesis breast cancer mouse models |
| title | Cellular Plasticity in Mammary Gland Development and Breast Cancer |
| title_full | Cellular Plasticity in Mammary Gland Development and Breast Cancer |
| title_fullStr | Cellular Plasticity in Mammary Gland Development and Breast Cancer |
| title_full_unstemmed | Cellular Plasticity in Mammary Gland Development and Breast Cancer |
| title_short | Cellular Plasticity in Mammary Gland Development and Breast Cancer |
| title_sort | cellular plasticity in mammary gland development and breast cancer |
| topic | cellular plasticity epithelial-to-mesenchymal transition mammary gland development tumorigenesis breast cancer mouse models |
| url | https://www.mdpi.com/2072-6694/15/23/5605 |
| work_keys_str_mv | AT madisonnwicker cellularplasticityinmammaryglanddevelopmentandbreastcancer AT kayuwewagner cellularplasticityinmammaryglanddevelopmentandbreastcancer |