Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms

Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms

Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been shown to be a negative regulator of osteoclast differentiation, but the precise mechanisms have not yet been established. We examined the precise roles of Nrf2 in regulating antioxidants and reactive oxygen species (ROS) levels, especially...

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Bibliographic Details
Main Authors: Yang Yang, Zhiyuan Liu, Jinzhi Wu, Simeng Bao, Yanshuai Wang, Jiliang Li, Tao Song, Yongxin Sun, Jingbo Pi
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Antioxidants
Subjects:
Nrf2
ROS
c-FOS
osteoclast differentiation
Online Access:https://www.mdpi.com/2076-3921/12/12/2094

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