Liver’s influence on the brain through the action of bile acids
The liver partakes as a sensor and effector of peripheral metabolic changes and a regulator of systemic blood and nutrient circulation. As such, abnormalities arising from liver dysfunction can influence the brain in multiple ways, owing to direct and indirect bilateral communication between the liv...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1123967/full |
| _version_ | 1828045208496898048 |
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| author | Xin Yi Yeo Xin Yi Yeo Li Yang Tan Li Yang Tan Woo Ri Chae Woo Ri Chae Dong-Yup Lee Yong-An Lee Torsten Wuestefeld Torsten Wuestefeld Torsten Wuestefeld Sangyong Jung Sangyong Jung |
| author_facet | Xin Yi Yeo Xin Yi Yeo Li Yang Tan Li Yang Tan Woo Ri Chae Woo Ri Chae Dong-Yup Lee Yong-An Lee Torsten Wuestefeld Torsten Wuestefeld Torsten Wuestefeld Sangyong Jung Sangyong Jung |
| author_sort | Xin Yi Yeo |
| collection | DOAJ |
| description | The liver partakes as a sensor and effector of peripheral metabolic changes and a regulator of systemic blood and nutrient circulation. As such, abnormalities arising from liver dysfunction can influence the brain in multiple ways, owing to direct and indirect bilateral communication between the liver and the brain. Interestingly, altered bile acid composition resulting from perturbed liver cholesterol metabolism influences systemic inflammatory responses, blood-brain barrier permeability, and neuron synaptic functions. Furthermore, bile acids produced by specific bacterial species may provide a causal link between dysregulated gut flora and neurodegenerative disease pathology through the gut-brain axis. This review will cover the role of bile acids—an often-overlooked category of active metabolites—in the development of neurological disorders associated with neurodegeneration. Further studies into bile acid signaling in the brain may provide insights into novel treatments against neurological disorders. |
| first_indexed | 2024-04-10T18:07:03Z |
| format | Article |
| id | doaj.art-51a3148005c24580b290d41f0f4f9e6f |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-10T18:07:03Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-51a3148005c24580b290d41f0f4f9e6f2023-02-02T12:38:24ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-02-011710.3389/fnins.2023.11239671123967Liver’s influence on the brain through the action of bile acidsXin Yi Yeo0Xin Yi Yeo1Li Yang Tan2Li Yang Tan3Woo Ri Chae4Woo Ri Chae5Dong-Yup Lee6Yong-An Lee7Torsten Wuestefeld8Torsten Wuestefeld9Torsten Wuestefeld10Sangyong Jung11Sangyong Jung12Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeDepartment of BioNano Technology, Gachon University, Seongnam, South KoreaSchool of Chemical Engineering, Sungkyunkwan University, Suwon, South KoreaGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeSchool of Biological Sciences, Nanyang Technological University, Singapore, SiingaporeNational Cancer Centre Singapore, Singapore, SingaporeInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore, SingaporeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeThe liver partakes as a sensor and effector of peripheral metabolic changes and a regulator of systemic blood and nutrient circulation. As such, abnormalities arising from liver dysfunction can influence the brain in multiple ways, owing to direct and indirect bilateral communication between the liver and the brain. Interestingly, altered bile acid composition resulting from perturbed liver cholesterol metabolism influences systemic inflammatory responses, blood-brain barrier permeability, and neuron synaptic functions. Furthermore, bile acids produced by specific bacterial species may provide a causal link between dysregulated gut flora and neurodegenerative disease pathology through the gut-brain axis. This review will cover the role of bile acids—an often-overlooked category of active metabolites—in the development of neurological disorders associated with neurodegeneration. Further studies into bile acid signaling in the brain may provide insights into novel treatments against neurological disorders.https://www.frontiersin.org/articles/10.3389/fnins.2023.1123967/fullliverbrainbile acidneurodegenerationgut microbiome |
| spellingShingle | Xin Yi Yeo Xin Yi Yeo Li Yang Tan Li Yang Tan Woo Ri Chae Woo Ri Chae Dong-Yup Lee Yong-An Lee Torsten Wuestefeld Torsten Wuestefeld Torsten Wuestefeld Sangyong Jung Sangyong Jung Liver’s influence on the brain through the action of bile acids Frontiers in Neuroscience liver brain bile acid neurodegeneration gut microbiome |
| title | Liver’s influence on the brain through the action of bile acids |
| title_full | Liver’s influence on the brain through the action of bile acids |
| title_fullStr | Liver’s influence on the brain through the action of bile acids |
| title_full_unstemmed | Liver’s influence on the brain through the action of bile acids |
| title_short | Liver’s influence on the brain through the action of bile acids |
| title_sort | liver s influence on the brain through the action of bile acids |
| topic | liver brain bile acid neurodegeneration gut microbiome |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1123967/full |
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