Current methods of studying of the proliferative activity in experiment
Aims. To analyze the contemporary scientifi c literature data about methods of determining of the proliferative activity, as well as the choice of an optimal method for its assessing in tissues with expected low proliferative activity. Methods and results. This is necessary to select an optimal me...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaporozhye State Medical University
2014-04-01
|
| Series: | Patologìâ |
| Subjects: | |
| Online Access: | http://pat.zsmu.edu.ua/article/view/25201/22627 |
| _version_ | 1811313662289248256 |
|---|---|
| author | T. V. Ivanenko T. V. Abramova N. V. Kuzo S. V. Tyshchenko |
| author_facet | T. V. Ivanenko T. V. Abramova N. V. Kuzo S. V. Tyshchenko |
| author_sort | T. V. Ivanenko |
| collection | DOAJ |
| description | Aims. To analyze the contemporary scientifi c literature data about methods of determining of the proliferative activity, as well as the
choice of an optimal method for its assessing in tissues with expected low proliferative activity.
Methods and results. This is necessary to select an optimal method for assessing of the proliferative activity in tissues with expected
low proliferative activity. The article gives a detailed analysis of the current literature, describes various methods of studying of the
proliferative activity of tissues in experiment.
Conclusion. Bromodeoxyuridine is a versatile and highly effective marker of DNA replication and cell proliferation, allowing carrying
out a dynamic observation of the experiment, including tissues with expected low proliferative activity. It can be widely used
in chronic experiments on small rodents, in the simulation of various pathologies and studying the effect of pharmaceuticals on the activity of proliferation. |
| first_indexed | 2024-04-13T10:57:47Z |
| format | Article |
| id | doaj.art-51a31b70cc164d88bb945d14f00de5e6 |
| institution | Directory Open Access Journal |
| issn | 2306-8027 2310-1237 |
| language | English |
| last_indexed | 2024-04-13T10:57:47Z |
| publishDate | 2014-04-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Patologìâ |
| spelling | doaj.art-51a31b70cc164d88bb945d14f00de5e62022-12-22T02:49:29ZengZaporozhye State Medical UniversityPatologìâ2306-80272310-12372014-04-0114710.14739/2310-1237.2014.1.25201Current methods of studying of the proliferative activity in experimentT. V. IvanenkoT. V. AbramovaN. V. KuzoS. V. TyshchenkoAims. To analyze the contemporary scientifi c literature data about methods of determining of the proliferative activity, as well as the choice of an optimal method for its assessing in tissues with expected low proliferative activity. Methods and results. This is necessary to select an optimal method for assessing of the proliferative activity in tissues with expected low proliferative activity. The article gives a detailed analysis of the current literature, describes various methods of studying of the proliferative activity of tissues in experiment. Conclusion. Bromodeoxyuridine is a versatile and highly effective marker of DNA replication and cell proliferation, allowing carrying out a dynamic observation of the experiment, including tissues with expected low proliferative activity. It can be widely used in chronic experiments on small rodents, in the simulation of various pathologies and studying the effect of pharmaceuticals on the activity of proliferation.http://pat.zsmu.edu.ua/article/view/25201/22627cell proliferationimmunohistochemistryPCNAantigen Ki67Bromodeoxyuridine |
| spellingShingle | T. V. Ivanenko T. V. Abramova N. V. Kuzo S. V. Tyshchenko Current methods of studying of the proliferative activity in experiment Patologìâ cell proliferation immunohistochemistry PCNA antigen Ki67 Bromodeoxyuridine |
| title | Current methods of studying of the proliferative activity in experiment |
| title_full | Current methods of studying of the proliferative activity in experiment |
| title_fullStr | Current methods of studying of the proliferative activity in experiment |
| title_full_unstemmed | Current methods of studying of the proliferative activity in experiment |
| title_short | Current methods of studying of the proliferative activity in experiment |
| title_sort | current methods of studying of the proliferative activity in experiment |
| topic | cell proliferation immunohistochemistry PCNA antigen Ki67 Bromodeoxyuridine |
| url | http://pat.zsmu.edu.ua/article/view/25201/22627 |
| work_keys_str_mv | AT tvivanenko currentmethodsofstudyingoftheproliferativeactivityinexperiment AT tvabramova currentmethodsofstudyingoftheproliferativeactivityinexperiment AT nvkuzo currentmethodsofstudyingoftheproliferativeactivityinexperiment AT svtyshchenko currentmethodsofstudyingoftheproliferativeactivityinexperiment |