Choroidal thickness and vascular microstructure parameters in Chinese school-age children with high hyperopia using optical coherence tomography
BackgroundThe current study was to evaluate the choroidal thickness (CT) and vascular microstructure parameters in Chinese children with high hyperopia through enhanced depth imaging optical coherence tomography (EDI-OCT).MethodsCross-sectional study. A total of 23 children with high hyperopia and 2...
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1092153/full |
| _version_ | 1811170873775751168 |
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| author | Dehai Zhu Dehai Zhu Hui Wang Ruoshi Li Ruoshi Li Jing Wen Jing Wen Ruiying Li Ruiying Li Jingjing Zhao Jingjing Zhao |
| author_facet | Dehai Zhu Dehai Zhu Hui Wang Ruoshi Li Ruoshi Li Jing Wen Jing Wen Ruiying Li Ruiying Li Jingjing Zhao Jingjing Zhao |
| author_sort | Dehai Zhu |
| collection | DOAJ |
| description | BackgroundThe current study was to evaluate the choroidal thickness (CT) and vascular microstructure parameters in Chinese children with high hyperopia through enhanced depth imaging optical coherence tomography (EDI-OCT).MethodsCross-sectional study. A total of 23 children with high hyperopia and 29 children with normal refractive status were retrospectively enrolled in the study. The measurement of the macular CT, 7 points: the sub-foveal area point, the temporal and nasal points at a radius of 0.5-mm, 1.5-mm, and 3-mm were measured. After binarization of the OCT images, the total choroidal area (TCA), stromal area (SA) as well as the luminal area (LA) were identified and measured. The choroidal vascularity index (CVI) was defined as the ratio of LA to TCA. The independent t-test for normal distributions and Kruskal-Wallis tests for non-normal distributions were used to compare other parameters between groups. The Tamhane's T2 test was performed to adjust for multiple comparisons between groups within each analysis.ResultsThe subfoveal CT (SFCT) in the high hypermetropic group was significantly thicker than that in normal controls (309.22 ± 53.14 μm vs. 291.27 ± 38.27 μm; P = 0.019). At 0.5 mm, 1.5 mm, and 3.0 mm in diameter, the nasal choroidal sectors of the high hyperopia eyes were significantly thicker than that of the control (P < 0.05). There was significant difference in the choroidal vascular parameters. TCA and LA in the high hyperopia eyes was significantly larger than that of the normal control eyes (3078129.54 ± 448271.18 μm2 vs. 2765218.17 ± 317827.19 μm2, 1926819.54 ± 229817.56 μm2 vs. 1748817.18 ± 191827.98 μm2; P = 0.009, P = 0.011; Table 2). SA values were 1086287.55 ± 212712.11 um2 in the high hyperopia eyes and 999712.71 ± 209838.12 μm2 in the control eyes. The CVI and LA/SA ratio values were differed significantly in the two groups (P = 0.019, P = 0.030, respectively). AL was significantly correlated with SFCT (r = −0.325, P = 0.047), but not significantly correlated with other parameters. Spherical equivalent (SE) was significantly correlated with AL and SFCT (r = −0.711, r = 0.311; P = 0.001, P = 0.016), whereas no significant association between sphere and other parameters.ConclusionThe choroidal structure of the high hyperopia eyes was different from the normal control eyes. The thicker SFCT, higher LA, and TCA were characteristic of high hyperopia eyes. Choroidal blood flow may be decreased in amblyopic eyes. SFCT of high hyperopia children abnormally increased and correlated with shorter AL and higher SE. AL and SE affect choroidal structure and vascular density. |
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| last_indexed | 2024-04-10T17:03:59Z |
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| series | Frontiers in Pediatrics |
| spelling | doaj.art-51a41e8ca66a42b3b8656f6b76694ff82023-02-06T06:53:11ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-02-011110.3389/fped.2023.10921531092153Choroidal thickness and vascular microstructure parameters in Chinese school-age children with high hyperopia using optical coherence tomographyDehai Zhu0Dehai Zhu1Hui Wang2Ruoshi Li3Ruoshi Li4Jing Wen5Jing Wen6Ruiying Li7Ruiying Li8Jingjing Zhao9Jingjing Zhao10Department of Pediatric Ophthalmology, Peking University First Hospital, Beijing, ChinaPeking University Children Vision Institute, Beijing, ChinaDepartment of Pediatric Ophthalmology, Peking University First Hospital, Beijing, ChinaDepartment of Pediatric Ophthalmology, Peking University First Hospital, Beijing, ChinaPeking University Children Vision Institute, Beijing, ChinaDepartment of Pediatric Ophthalmology, Peking University First Hospital, Beijing, ChinaPeking University Children Vision Institute, Beijing, ChinaDepartment of Pediatric Ophthalmology, Peking University First Hospital, Beijing, ChinaPeking University Children Vision Institute, Beijing, ChinaDepartment of Pediatric Ophthalmology, Peking University First Hospital, Beijing, ChinaPeking University Children Vision Institute, Beijing, ChinaBackgroundThe current study was to evaluate the choroidal thickness (CT) and vascular microstructure parameters in Chinese children with high hyperopia through enhanced depth imaging optical coherence tomography (EDI-OCT).MethodsCross-sectional study. A total of 23 children with high hyperopia and 29 children with normal refractive status were retrospectively enrolled in the study. The measurement of the macular CT, 7 points: the sub-foveal area point, the temporal and nasal points at a radius of 0.5-mm, 1.5-mm, and 3-mm were measured. After binarization of the OCT images, the total choroidal area (TCA), stromal area (SA) as well as the luminal area (LA) were identified and measured. The choroidal vascularity index (CVI) was defined as the ratio of LA to TCA. The independent t-test for normal distributions and Kruskal-Wallis tests for non-normal distributions were used to compare other parameters between groups. The Tamhane's T2 test was performed to adjust for multiple comparisons between groups within each analysis.ResultsThe subfoveal CT (SFCT) in the high hypermetropic group was significantly thicker than that in normal controls (309.22 ± 53.14 μm vs. 291.27 ± 38.27 μm; P = 0.019). At 0.5 mm, 1.5 mm, and 3.0 mm in diameter, the nasal choroidal sectors of the high hyperopia eyes were significantly thicker than that of the control (P < 0.05). There was significant difference in the choroidal vascular parameters. TCA and LA in the high hyperopia eyes was significantly larger than that of the normal control eyes (3078129.54 ± 448271.18 μm2 vs. 2765218.17 ± 317827.19 μm2, 1926819.54 ± 229817.56 μm2 vs. 1748817.18 ± 191827.98 μm2; P = 0.009, P = 0.011; Table 2). SA values were 1086287.55 ± 212712.11 um2 in the high hyperopia eyes and 999712.71 ± 209838.12 μm2 in the control eyes. The CVI and LA/SA ratio values were differed significantly in the two groups (P = 0.019, P = 0.030, respectively). AL was significantly correlated with SFCT (r = −0.325, P = 0.047), but not significantly correlated with other parameters. Spherical equivalent (SE) was significantly correlated with AL and SFCT (r = −0.711, r = 0.311; P = 0.001, P = 0.016), whereas no significant association between sphere and other parameters.ConclusionThe choroidal structure of the high hyperopia eyes was different from the normal control eyes. The thicker SFCT, higher LA, and TCA were characteristic of high hyperopia eyes. Choroidal blood flow may be decreased in amblyopic eyes. SFCT of high hyperopia children abnormally increased and correlated with shorter AL and higher SE. AL and SE affect choroidal structure and vascular density.https://www.frontiersin.org/articles/10.3389/fped.2023.1092153/fullchoroidal thicknesschoroidal vascularity indexEDI-OCT choroidal thicknessEDI-OCThigh hyperopia |
| spellingShingle | Dehai Zhu Dehai Zhu Hui Wang Ruoshi Li Ruoshi Li Jing Wen Jing Wen Ruiying Li Ruiying Li Jingjing Zhao Jingjing Zhao Choroidal thickness and vascular microstructure parameters in Chinese school-age children with high hyperopia using optical coherence tomography Frontiers in Pediatrics choroidal thickness choroidal vascularity index EDI-OCT choroidal thickness EDI-OCT high hyperopia |
| title | Choroidal thickness and vascular microstructure parameters in Chinese school-age children with high hyperopia using optical coherence tomography |
| title_full | Choroidal thickness and vascular microstructure parameters in Chinese school-age children with high hyperopia using optical coherence tomography |
| title_fullStr | Choroidal thickness and vascular microstructure parameters in Chinese school-age children with high hyperopia using optical coherence tomography |
| title_full_unstemmed | Choroidal thickness and vascular microstructure parameters in Chinese school-age children with high hyperopia using optical coherence tomography |
| title_short | Choroidal thickness and vascular microstructure parameters in Chinese school-age children with high hyperopia using optical coherence tomography |
| title_sort | choroidal thickness and vascular microstructure parameters in chinese school age children with high hyperopia using optical coherence tomography |
| topic | choroidal thickness choroidal vascularity index EDI-OCT choroidal thickness EDI-OCT high hyperopia |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1092153/full |
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